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醫療團隊

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醫師介紹

  •

賴振宏醫師

氣喘、過敏、紅斑性狼瘡、自體免疫疾病、類風濕性關節炎、僵直性脊椎炎、痛風關節炎
  • 國語,英語,閩南語,客語
  • 教授
醫師網路掛號
直接點選進入醫師網路掛號畫面
醫師資歷
  • 現職
    • 學術組教授
    • 風濕過敏免疫科主治醫師
  • 學歷
    • 國防醫學院醫學系
    • 美國醫師執照檢覈考試通過 (FMGEMS)
    • 美國德州醫學中心貝勒醫學院免疫學博士
  • 經歷
    • 長庚醫院風濕過敏免疫科主治醫師
    • 國防醫學院預防醫學研究所所長
    • 三軍總醫院風濕過敏免疫科主任醫師
  • 學會與認證
    • Chinese Board of Allergy and Immunology
    • Chinese Board of Rheumatology
    • Chinese Board of Internal Medicine
    • FMGEMS (Foreign Medical Graduate Examination of Medical Science, compatible with VQE, USMLE), USA
    • National Board Qualification for Physicians
  • 論文及期刊發表
    • Potential therapeutic targets beyond cytokines and Janus kinases for autoimmune arthritis,
      Biochem Pharmacol 213 115622. (2023).
      Wu, C.Y., Yang, H.Y., Lai JH*
    • Ferroptosis and Autoimmune Diseases.
      Front Immunol 13, 916664. (2022).
      Lai, B., Wu, C.H., Wu, C.Y., Luo, S.F., and Lai JH*
    • Vitamin D Supplementation in Patients with Juvenile Idiopathic Arthritis.
      Nutrients 14.(2022).
      Wu, C.Y., Yang, H.Y., Luo, S.F., Huang, J.L., and Lai JH*
    • Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
      Biochem Pharmacol 2021, 193, 114760, doi:10.1016/j.bcp.2021.114760.
      Tzeng, H.T.; Chyuan, I.T.; Lai JH*
    • (2021). Signals and Mechanisms Regulating Monocyte and Macrophage Activation in the Pathogenesis of Juvenile Idiopathic Arthritis.
      Int J Mol Sci 22.
      Wu, C.Y., Yang, H.Y., Huang, J.L., and Lai JH*
    • Mitochondrial protein CMPK2 mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways.
      iScience 24(6):102498. doi: 10.1016/j.isci.2021.102498.
      Lai JH, Wu DW, Wu CH, Hung LF, Huang CY, Ka SM, Chen A, Chang ZF, Ho LJ.
    • Mitochondrial protein CMPK2 regulates IFN alpha-enhanced foam cell formation, potentially contributing to premature atherosclerosis in SLE.
      Arthritis Res Ther 23(1):120. doi: 10.1186/s13075-021-02470-6.
      Lai, J.H., Hung, L.F., Huang, C.Y., Wu, D.W., Wu, C.H., and Ho, L.J. (2021).
    • From Rheumatoid Factor to Anti-Citrullinated Protein Antibodies and Anti-Carbamylated Protein Antibodies for Diagnosis and Prognosis Prediction in Patients with Rheumatoid Arthritis.
      Int J Mol Sci 22.
      Wu, C.Y., Yang, H.Y., Luo, S.F., and Lai JH*
    • Epigallocatechin-3-gallate exhibits immunomodulatory effects in human primary T cells.
      Biochem Biophys Res Commun 550, 70-76.
      Huang, S.C., Kao, Y.H., Shih, S.F., Tsai, M.C., Lin, C.S., Chen, L.W., Chuang, Y.P., Tsui, P.F., Ho, L.J., Lai, J.H., et al.
    • Activation of c-Jun N-Terminal Kinase, a Potential Therapeutic Target in Autoimmune Arthritis.
      Cells 2020;9:
      Lai B, Wu CH, Lai JH*.
    • Anti-Citrullinated Protein Antibodies in Patients with Rheumatoid Arthritis: Biological Effects and Mechanisms of Immunopathogenesis.
      Int J Mol Sci 2020;21:
      Wu CY, Yang HY, Lai JH*.
    • New insights into the IL-12 and IL-23: From a molecular basis to clinical application in immune-mediated inflammation and cancers.
      Biochem Pharmacol 2020;175:113928.
      Chyuan IT, Lai JH*.
    • Monosodium urate crystals induced ICAM-1 expression and cell-cell adhesion in renal mesangial cells: Implications for the pathogenesis of gouty nephropathy.
      J Microbiol Immunol Infect 2020;53:23-32.
      Luo SF, Chin CY, Ho LJ, Tseng WY, Kuo CF, Lai JH*.
    • A new laboratory surrogate (Monocyte Chemotactic Protein-1) for Disease Activity Score28: a favourable indicator for remission in rheumatoid arthritis.
      Sci Rep 2020;10:8238.
      Liou LB, Fang YF, Tan CF, Lai JH, Jang SS, Tsai PH, et al.
    • Compound K inhibits priming and mitochondria-associated activating signals of NLRP3 inflammasome in renal tubulointerstitial lesions.
      Nephrol Dial Transplant 2020;35:74-85.
      Hsu WH, Hua KF, Tuan LH, Tsai YL, Chu LJ, Lee YC, et al.
    • Anti-inflammatory and anti-osteoarthritis effects of Cm-02 and Ck-02.
      Biochem Biophys Res Commun 2019;517:155-163.
      Ho YJ, Lu JW, Ho LJ, Lai JH, Huang HS, Lee CC, et al.
    • Targeting the CD40-CD154 Signaling Pathway for Treatment of Autoimmune Arthritis.
      Cells 2019;8:
      Lai JH*, Luo SF, Ho LJ.
    • Pitavastatin Exerts Potent Anti-Inflammatory and Immunomodulatory Effects via the Suppression of AP-1 Signal Transduction in Human T Cells.
      Int J Mol Sci 2019;20:
      Chen LW, Lin CS, Tsai MC, Shih SF, Lim ZW, Chen SJ, et al.
    • Useful message in choosing optimal biological agents for patients with autoimmune arthritis”
      Biochem Pharmacol, 2019,165, 99-111.
      Lai, J.H.*, Ling, X.C., and Ho, L.J.*
    • Chondroprotective Effects and Mechanisms of Dextromethorphan: Repurposing Antitussive Medication for Osteoarthritis Treatment.
      Int J Mol Sci 2018;19:
      Chen LW, Liu FC, Hung LF, Huang CY, Lien SB, Lin LC, et al.
    • Liu FC, Lu JW, Chien CY, Huang HS, Lee CC, Lien SB, et al.Similarity with Quercetin.
      Int J Mol Sci 2018;19:
      Arthroprotective Effects of Cf-02 Sharing Structural
    • Infection with the dengue RNA virus activates TLR9 signaling in human dendritic cells.
      EMBO Rep 2018;19: e46182.
      Lai JH, Wang MY, Huang CY, Wu CH, Hung LF, Yang CY, et al.
    • Operation of mitochondrial machinery in viral infection-induced immune responses.
      Biochem Pharmacol 2018;156:348-356.
      Lai JH, Luo SF, Ho LJ.
    • Hydroxychloroquine and risk of cancer in patients with primary Sjogren syndrome: propensity score matched landmark analysis.
      Oncotarget 2017;8:80461-80471.
      Fang YF, Chen YF, Chung TT, See LC, Yu KH, Luo SF, Kuo CF, Lai JH*.
    • Translational Implication of Galectin-9 in the Pathogenesis and Treatment of Viral Infection.
      Int J Mol Sci 2017;18:
      Lai JH*, Luo SF, Wang MY, Ho LJ.
    • JNK/AP-1 activation contributes to tetrandrine resistance in T-cell acute lymphoblastic leukaemia.
      Acta Pharmacol Sin 2017;38:1171-1183.
      Liou JT, Lin CS, Liao YC, Ho LJ, Yang SP, Lai JH*.
    • Physiological concentrations of soluble uric acid are chondroprotective and anti-inflammatory.
      Sci Rep 2017;7:2359.
      Lai JH, Luo SF, Hung LF, Huang CY, Lien SB, Lin LC, et al.
    • Epigallocatechin-3-gallate Reduces Scavenger Receptor A Expression and Foam Cell Formation in Human Macrophages.
      J Agric Food Chem 2017;65:3141-3150.
      Chen SJ, Kao YH, Jing L, Chuang YP, Wu WL, Liu ST, Huang SM, Lai JH, Ho LJ, Tsai MC, and Lin CS.
    • Pharmacological intervention for dengue virus infection.
      Biochem Pharmacol 2017;129:14-25.
      Lai JH*, Lin YL, and Hsieh SL.
    • Safety and efficacy of oral febuxostat for treatment of HLA-B*5801-negative gout: a randomized, open-label, multicentre, allopurinol-controlled study.
      Scand J Rheumatol 2016;45:304-11.
      Yu KH, Lai JH, Hsu PN, Chen DY, Chen CJ, Lin HY.
    • A New Application of Parallel Synthesis Strategy for Discovery of Amide-Linked Small Molecules as Potent Chondroprotective Agents in TNF-alpha-Stimulated Chondrocytes.
      PLoS One 2016;11:e0149317.
      Lee CC, Lo Y, Ho LJ, Lai JH, Lien SB, Lin LC, et al.
    • Gentiana scabra Reduces SR-A Expression and Oxidized-LDL Uptake in Human Macrophages.
      Acta Cardiol Sin 2016;32:460-6.
      Lin CS, Liu PY, Lian CH, Lin CH, Lai JH, Ho LJ, et al.
    • Dengue virus infection induces interferon-lambda1 to facilitate cell migration.
      Sci Rep 2016;6:24530. doi: 10.1038/srep24530.
      Hsu YL, Wang MY, Ho LJ, and Lai JH*.
    • Biological effects of interleukin-6: Clinical applications in autoimmune diseases and cancers.
      Biochem Pharmacol 2015 (available on line June 12, 2015).
      Ho LJ, Luo SF, and Lai JH*.
    • Up-regulation of galectin-9 induces cell migration in human dendritic cells infected with dengue virus.
      J Cell Mol Med 2015 (in press).
      Hsu YL, Wang MY, Ho LJ, Huang CY, and Lai JH*.
    • Protein kinase C isoforms in atherosclerosis: Pro- or anti-inflammatory?
      Biochem Pharmacol 2014;88:139-49.
      Fan HC, Fernandez-Hernando C, Lai JH*.
    • Differential immunomodulatory effects by Tripterygium wilfordii Hook f-derived refined extract PG27 and its purified component PG490 (triptolide) in human peripheral blood T cells: potential therapeutics for arthritis and possible mechanisms explaining in part Chinese herbal theory "Junn-Chenn-Zuou-SS".
      J Transl Med 2013;11:294.
      Ho LJ, Chang WL, Chen A, Chao P, Lai JH*.
    • Small-molecule inhibitors for autoimmune arthritis: success, failure and the future.
      Eur J Pharmacol 2015 (in press).
      Ho LJ, Lai JH*.
    • Useful biomarkers for assessment of hepatitis C virus infection-associated autoimmune disorders.
      World J Gastroenterol 2014;20:2962-70.
      Yang DH, Ho LJ, Lai JH*.
    • PKCdelta signalling regulates SR-A and CD36 expression and foam cell formation.
      Cardiovasc Res 2012;95:346-55.
      Lin CS, Lin FY, Ho LJ, Tsai CS, Cheng SM, Wu WL, Huang CY, Lian CH, Yang SP, Lai JH*.
    • Antroquinonol differentially modulates T cell activity and reduces interleukin-18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis.
      Arthritis Rheum 2012;64:232-42.
      Tsai PY, Ka SM, Chang JM, Lai JH, Dai MS, Jheng HL, Kuo MT, Chen P, Chen A.
    • A salicylate-based small molecule HS-Cm exhibits immunomodulatory effects and inhibits dipeptidyl peptidase-IV activity in human T cells.
      Eur J Pharmacol 2014;726C:124-32.
      Liou JT, Huang HS, Chiang ML, Lin CS, Yang SP, Ho LJ, Lai JH*.
    • Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes: Potential Therapeutics for Osteoarthritis.
      PLoS One 2013;8:e82033.
      Ho LJ, Hung LF, Liu FC, Hou TY, Lin LC, Huang CY, Lai JH*.
    • Protective roles of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in dengue virus infection of human lung epithelial cells.
      PLoS One 2013;8:e79518.
      Hsu YL, Shi SF, Wu WL, Ho LJ, Lai JH*.
    • Janus kinase/signal transducer and activator of transcription 3 signaling pathway is crucial in chemokine production from hepatocytes infected by dengue virus.
      Exp Biol Med (Maywood) 2011;236:1156-65.
      Tsai YT, Chen YH, Chang DM, Chen PC, Lai JH*.
    • A Benzamide-Linked Small Molecule HS-Cf Inhibits TNF-alpha-Induced Interferon Regulatory Factor-1 in Porcine Chondrocytes: A Potential Disease-Modifying Drug for Osteoarthritis Therapeutics.
      J Clin Immunol 2011;31:1131-42.
      Liu FC, Huang HS, Huang CY, Yang R, Chang DM, Lai JH*, Ho LJ.
    • Magnesium lithospermate B mediates anti-inflammation targeting activator protein-1 and nuclear factor-kappa B signaling pathways in human peripheral T lymphocytes.
      Int Immunopharmacol 2012;13:354-61.
      Cheng CC, Yang SP, Lin WS, Ho LJ, Lai JH, Cheng SM, Lin WY.
    • Immunosuppressive Effects and Mechanisms of Leflunomide in Dengue Virus Infection of Human Dendritic Cells.
      J Clin Immunol 2011;31: 1065-78.
      Wu WL, Ho LJ, Chen PC, Tsai YT, Hsu ST, Chang DM, Lai JH*.
    • Modulation of human T cells signaling transduction by lovastatin.
      Int J Cardiol 2010;140:24-33.
      Cheng SM, Lai JH, Yang SP, Tsao TP, Ho LJ, Liou JT, Cheng CC.
    • The modulatory mechanisms of fenofibrate on human primary T cells.
      Eur J Pharm Sci 2010;40:316-24.
      Cheng SM, Chu KM, Lai JH.
    • A/H1N1 influenza vaccination in patients with systemic lupus erythematosus: safety and immunity.
      Vaccine 2011;29:444-50.
      Lu CC, Wang YC, Lai JH, Lee TS, Lin HT, Chang DM.
    • Phytoestrogen bavachin mediates anti-inflammation targeting Ikappa B kinase-I kappaB alpha-NF-kappaB signaling pathway in chondrocytes in vitro.
      Eur J Pharmacol 2010;636:181-8.
      Cheng CC, Chen YH, Chang WL, Yang SP, Chang DM, Lai JH*, Ho LJ.
    • A spontaneous intercostal artery hemorrhage in systemic lupus erythematosus.
      Rheumatol Int 2012;32:829-31.
      Lu CC, Chen CH, Yeh SF, Lai JH, Chang DM.
    • Remitting seronegative symmetrical synovitis with pitting edema following acute intracranial hemorrhage.
      Rheumatol Int 2011;31:101-4.
      Yang DH, Chang DM, Lai JH, Huang GS, Chang WC, Hou TY.
    • Peripheral arthritis caused by Mycobacterium avium-intracellulare in a patient with ankylosing spondylitis.
      J Clin Rheumatol 2009;15:323-4.
      Yang DH, Chang WC, Cheng MF, Lai JH, Chang DM, Chen CH.
    • Usefulness of erythrocyte-bound C4d as a biomarker to predict disease activity in patients with systemic lupus erythematosus.
      Rheumatology (Oxford) 2009;48:1083-7.
      Yang DH, Chang DM, Lai JH, Lin FH, Chen CH.
    • Significantly higher percentage of circulating CD27(high) plasma cells in systemic lupus erythematosus patients with infection than with disease flare-up.
      Yonsei Med J 2010;51:924-31.
      Yang DH, Chang DM, Lai JH, Lin FH, Chen CH.
    • Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes.
      Arthritis Res Ther 2010;12:R167.
      Liu FC, Hung LF, Wu WL, Chang DM, Huang CY, Lai JH*, Ho LJ.
    • Triggering of DC migration by dengue virus stimulation of COX-2-dependent signaling cascades in vitro highlights the significance of these cascades beyond inflammation.
      Eur J Immunol 2009;39:3413-22.
      Wu WL, Ho LJ, Chang DM, Chen CH, Lai JH*.
    • Etanercept as a rescue agent in patient with adult onset Still's disease complicated with congestive heart failure.
      Rheumatol Int 2008;29:95-8.
      Yang DH, Chang DM, Lai JH, Kuo SY, Ho TY, Lin KM, Chen CH.
    • Suppression of tissue necrosis factor-alpha or hydrogen peroxide-activated primary human T lymphocytes by Ginkgo biloba extract through down-regulation of activator protein-1 signal transduction.
      Phytomedicine 2008;15:170-6.
      Tsao TP, Lai JH, Yang SP, Ho LJ, Liou JT, Cheng CC, Cheng SM.
    • Acupuncture-associated Listeria monocytogenes arthritis in a patient with rheumatoid arthritis.
      Joint Bone Spine 2008;75:502-3.
      Tien CH, Huang GS, Chang CC, Chang DM, Lai JH*.
    • Usefulness of anti-CCP antibodies in patients with hepatitis C virus infection with or without arthritis, rheumatoid factor, or cryoglobulinemia.
      Clin Rheumatol 2008;27:463-7.
      Liu FC, Chao YC, Hou TY, Chen HC, Shyu RY, Hsieh TY, Chen CH, Chang DM, Lai JH*.
    • Differential effects of triptolide and tetrandrine on activation of COX-2, NF-kappaB, and AP-1 and virus production in dengue virus-infected human lung cells.
      Eur J Pharmacol 2008;589:288-98.
      Liou JT, Chen ZY, Ho LJ, Yang SP, Chang DM, Liang CC, Lai JH*.
    • Formation of numerous rice bodies: an unusual finding of adult-onset Still's disease.
      Clin Rheumatol 2008;27 Suppl 2:S55-7.
      Lin KM, Lai JH, Chang CC, Lin CK, Chang DM, Chen CH.
    • Retinoid acid inhibits IL-1-induced iNOS, COX-2 and chemokine production in human chondrocytes.
      Immunol Invest 2008;37:675-93.
      Hung LF, Lai JH, Lin LC, Wang SJ, Hou TY, Chang DM, Liang CC, Ho LJ.
    • Interleukin (IL)-23 p19 expression induced by IL-1beta in human fibroblast-like synoviocytes with rheumatoid arthritis via active nuclear factor-kappaB and AP-1 dependent pathway.
      Rheumatology (Oxford) 2007;46:1266-73.
      Liu FL, Chen CH, Chu SJ, Chen JH, Lai JH, Sytwu HK, Chang DM.
    • Purtscher's-like retinopathy as an initial presentation of adult-onset Still's disease: a case report and review of the literature.
      Clin Rheumatol 2007;26:1204-6.
      Liu FC, Chiang SY, Chang DM, Lai JH, Hou TY, Chen CH.
    • Autoimmune hepatitis with raised alpha-fetoprotein level as the presenting symptoms of systemic lupus erythematosus: a case report.
      Rheumatol Int 2007;27:489-91.
      Liu FC, Chang DM, Lai JH, Lin CK, Chen HC, Hou TY, Kuo SY.
    • Usefulness of human leucocyte antigen-B27 subtypes in predicting ankylosing spondylitis: Taiwan experience.
      Intern Med J 2007;37:749-52.
      Hou TY, Chen HC, Chen CH, Chang DM, Liu FC, Lai JH*.
    • Activin A suppresses interleukin-1-induced matrix metalloproteinase 3 secretion in human chondrosarcoma cells.
      Rheumatol Int 2007;27:1049-55.
      Chang DM, Liu SH, Lee HS, Lai JH, Chen CH.
    • Thymoma and hypogammaglobulinemia (Good's syndrome): a case report.
      J Microbiol Immunol Infect 2005;38:218-20.
      Tsai YG, Lai JH, Kuo SY, Chen HC, Chang DM.
    • Taiwan experience with etanercept in juvenile rheumatoid arthritis.
      J Microbiol Immunol Infect 2005;38:451-4.
      Lai JH*.
    • Sweet's syndrome as an initial presentation in systemic lupus erythematosus: a case report and review of the literature.
      Lupus 2005;14:399-402.
      Hou TY, Chang DM, Gao HW, Chen CH, Chen HC, Lai JH*.
    • Retinoic acid blocks pro-inflammatory cytokine-induced matrix metalloproteinase production by down-regulating JNK-AP-1 signaling in human chondrocytes.
      Biochem Pharmacol 2005;70:200-8.
      Ho LJ, Lin LC, Hung LF, Wang SJ, Lee CH, Chang DM, Lai JH*, Tai TY.
    • Dengue virus type 2 antagonizes IFN-alpha but not IFN-gamma antiviral effect via down-regulating Tyk2-STAT signaling in the human dendritic cell.
      J Immunol 2005;174:8163-72.
      Ho LJ, Hung LF, Weng CY, Wu WL, Chou P, Lin YL, Chang DM, Tai TY, Lai JH*.
    • Systemic lupus erythematosus with simultaneous onset of Kikuchi-Fujimoto's disease complicated with antiphospholipid antibody syndrome: a case report and review of the literature.
      Rheumatol Int 2005;25:303-6.
      Chen HC, Lai JH, Huang GS, Gao HW, Chen CH, Kuo SY, Chang DM.
    • Immunosuppressive iridoids from the fruits of Gardenia jasminoides.
      J Nat Prod 2005;68:1683-5.
      Chang WL, Wang HY, Shi LS, Lai JH, Lin HC.
    • Carvedilol differentially regulates cytokine production from activated human peripheral blood mononuclear cells.
      Cardiovasc Drugs Ther 2004;18:183-8.
      Yang SP, Ho LJ, Cheng SM, Hsu YL, Tsao TP, Chang DM, Lai JH*.
    • An unrecognized cause of oedema in a patient with lupus nephritis: protein losing enteropathy.
      Nephrol Dial Transplant 2004;19:2149-50.
      Wu CC, Lin SH, Chu P, Lai JH, Chang DM, Lin YF.
    • Infection of human dendritic cells by dengue virus activates and primes T cells towards Th0-like phenotype producing both Th1 and Th2 cytokines.
      Immunol Invest 2004;33:423-37.
      Ho LJ, Shaio MF, Chang DM, Liao CL, Lai JH*.
    • Chinese herbs as immunomodulators and potential disease-modifying antirheumatic drugs in autoimmune disorders.
      Curr Drug Metab 2004;5:181-92.
      Ho LJ, Lai JH*.
    • Plant alkaloid tetrandrine downregulates IkappaBalpha kinases-IkappaBalpha-NF-kappaB signaling pathway in human peripheral blood T cell.
      Br J Pharmacol 2004;143:919-27.
      Ho LJ, Juan TY, Chao P, Wu WL, Chang DM, Chang SY, Lai JH*.
    • Irbesartan inhibits human T-lymphocyte activation through downregulation of activator protein-1.
      Br J Pharmacol 2004;142:933-42.
      Cheng SM, Yang SP, Ho LJ, Tsao TP, Chang DM, Lai JH*.
    • Pleural effusion as a manifestation of Lyme disease.
      J Rheumatol 2004;31:811-3.
      Chen HC, Shih CM, Lai JH, Chao LL, Kuo SY, Chang DM.
    • Longitudinal myelitis as an initial manifestation of systemic lupus erythematosus.
      Am J Med Sci 2004;327:105-8.
      Chen HC, Lai JH, Juan CJ, Kuo SY, Chen CH, Chang DM.
    • Neutrophilic panniculitis with myelodysplastic syndromes presenting as pustulosis: case report and review of the literature.
      Am J Hematol 2004;76:61-5.
      Chen HC, Kao WY, Chang DM, Gao HW, Lai WY, Lai JH*.
    • Dual biological functions of an interleukin-1 receptor antagonist-interleukin-10 fusion protein and its suppressive effects on joint inflammation.
      Immunology 2004;112:643-50.
      Chang DM, Shyue SK, Liu SH, Chen YT, Yeh CY, Lai JH, Lee HS, Chen A.
    • Dehydroepiandrosterone suppresses interleukin 10 synthesis in women with systemic lupus erythematosus.
      Ann Rheum Dis 2004;63:1623-6.
      Chang DM, Chu SJ, Chen HC, Kuo SY, Lai JH.
    • The pharmacokinetics of interleukin-1 receptor antagonist in Chinese subjects with rheumatoid arthritis.
      Pharmacol Res 2004;50:371-6.
      Chang DM, Chang SY, Yeh MK, Lai JH.
    • Carvedilol, a new antioxidative beta-blocker, blocks in vitro human peripheral blood T cell activation by downregulating NF-kappaB activity.
      Cardiovasc Res 2003;59:776-87.
      Yang SP, Ho LJ, Lin YL, Cheng SM, Tsao TP, Chang DM, Hsu YL, Shih CY, Juan TY, Lai JH*.
    • Ruptured renal microaneurysms complicated with a retroperitoneal abscess for a patient with systemic lupus erythematosus.
      Lupus 2003;12:317-20.
      Tsai YG, Lai JH, Kuo SY, Chen HC, Wan HL, Chang DM.
    • Relationship between human lymphocyte antigen-B27 and clinical features of psoriatic arthritis.
      J Microbiol Immunol Infect 2003;36:101-4.
      Tsai YG, Chang DM, Kuo SY, Wang WM, Chen YC, Lai JH*.
    • Down-regulation of c-jun N-terminal kinase-activator protein-1 signaling pathway by Ginkgo biloba extract in human peripheral blood T cells.
      Biochem Pharmacol 2003;66:679-89.
      Cheng SM, Yang SP, Ho LJ, Tsao TP, Juan TY, Chang DM, Chang SY, Lai JH*.
    • Carvedilol modulates in-vitro granulocyte-macrophage colony-stimulating factor-induced interleukin-10 production in U937 cells and human monocytes.
      Immunol Invest 2003;32:43-58.
      Cheng SM, Yang SP, Ho LJ, Tsao TP, Chang DM, Lai JH*.
    • Immunosuppressive flavones and lignans from Bupleurum scorzonerifolium.
      Phytochemistry 2003;64:1375-9.
      Chang WL, Chiu LW, Lai JH, Lin HC.
    • Prognostic factors and fetal outcomes of lupus pregnancy in Taiwan.
      Clin Exp Rheumatol 2003;21:798.
      Chang DM, Wu YL, Chu SJ, Lai JH.
    • Immunomodulatory effects and mechanisms of plant alkaloid tetrandrine in autoimmune diseases.
      Acta Pharmacol Sin 2002;23:1093-101.
      Lai JH*.
    • Western and Chinese antirheumatic drug-induced T cell apoptotic DNA damage uses different caspase cascades and is independent of Fas/Fas ligand interaction.
      J Immunol 2001;166:6914-24.
      Lai JH*, Ho LJ, Lu KC, Chang DM, Shaio MF, Han SH.
    • Infection of human dendritic cells by dengue virus causes cell maturation and cytokine production.
      J Immunol 2001;166:1499-506.
      Ho LJ, Wang JJ, Shaio MF, Kao CL, Chang DM, Han SW, Lai JH*.
    • Aspirin differentially regulates endotoxin-induced IL-12 and TNF-alpha production in human dendritic cells.
      Scand J Rheumatol 2001;30:346-52.
      Ho LJ, Chang DM, Shiau HY, Chen CH, Hsieh TY, Hsu YL, Wong CS, Lai JH*.
    • Plant alkaloid tetrandrine and its analog block CD28-costimulated activities of human peripheral blood T cells: potential immunosuppressants in transplantation immunology.
      Transplantation 1999;68:1383-92.
      Lai JH*, Ho LJ, Kwan CY, Chang DM, Lee TC.
    • Plant alkaloid tetrandrine downregulates protein kinase C-dependent signaling pathway in T cells.
      Eur J Pharmacol 1999;367:389-98.
      Ho LJ, Chang DM, Lee TC, Chang ML, Lai JH*.
    • Mechanism of immunosuppression of the antirheumatic herb TWHf in human T cells.
      J Rheumatol 1999;26:14-24.
      Ho LJ, Chang DM, Chang ML, Kuo SY, Lai JH*.
    • Cell surface markers and circulating cytokines in graft versus host disease.
      Immunol Invest 1999;28:77-86.
      Chang DM, Wang CJ, Kuo SY, Lai JH.
    • Effects of anti-rheumatic herbal medicines on cellular adhesion molecules.
      Ann Rheum Dis 1999;58:366-71.
      Chang DM, Kuo SY, Lai JH, Chang ML.
    • RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter.
      Mol Cell Biol 1995;15:4260-71.
      Lai JH, Horvath G, Subleski J, Bruder J, Ghosh P, Tan TH.
    • Mechanisms of enhanced nuclear translocation of the transcription factors c-Rel and NF-kappa B by CD28 costimulation in human T lymphocytes.
      Ann N Y Acad Sci 1995;766:220-3.
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