您現在的位置 :

醫療團隊

專業的醫護人員，提供最佳的醫療服務

醫師介紹

  •

陳尚德醫師

一般神經內科、腦血管疾病、神經退化疾病、神經科學
  • 國語,英語,閩南語
  • 教授
醫師網路掛號
直接點選進入醫師網路掛號畫面
醫師資歷
  • 現職
    • 高雄長庚醫院 神經內科部 一般神經科 顧問級主治醫師
  • 學歷
    • 高雄醫學院醫學系
  • 經歷
    • 高雄長庚醫院 神經內科部 一般神經科 主治醫師
    • 林口長庚醫院 神經內科 主治醫師
    • University of Washington, Seattle, USA, Department of Neuropathology, Visiting Fellow
    • 林口長庚醫院 神經內科 住院醫師及研究員
    • Washington University in St.Louis, MO, USA, Department of Neurology, Research Fellow
  • 學會與認證
    • 台灣神經內科專科
  • 論文及期刊發表
    • Huang CY, Yang HI, Chen SD, Shaw FZ, Yang DI*. Protective effects of lipopolysaccharide preconditioning against nitric oxide neurotoxicity. J Neurosci Res. 2008 May 1;86(6):1277-89.

    • Tsai NW, Lu CH*, Chang WN, Shaw CF, Huang CR, Chen SD, Chuang YC, Lee LH, Jan CR. Dysregulation of Ca2+ movement in platelets from patients with acute ischaemic stroke. Clin Exp Pharmacol Physiol. 2009 Apr;36(4):380-5.

    • Weng SW, Lin TK, Liou CW, Chen SD, Wei YH, Lee HC, Chen IY, Hsieh CJ, Wang PW*. Peripheral blood mitochondrial DNA content and dysregulation of glucose metabolism. Diabetes Res Clin Pract. 2009 Jan;83(1):94-9.

    • Chuang YC, Chen SD, Liou CW, Lin TK, Chang WN, Chan SH, Chang AY. Contribution of nitric oxide, superoxide anion, and peroxynitrite to activation of mitochondrial apoptotic signaling in hippocampal CA3 subfield following experimental temporal lobe status epilepticus. Epilepsia. 2009 Apr;50(4):731-46.

    • Tsai NW, Chang WN, Shaw CF, Jan CR, Chang HW, Huang CR, Chen SD, Chuang YC, Lee LH, Wang HC, Lee TH, Lu CH*. Levels and value of platelet activation markers in different subtypes of acute non-cardio-embolic ischemic stroke. Thromb Res. 2009 Jun;124(2):213-8.

    • Wu CL, Chen SD, Hwang CS, Yang DI*. Sonic hedgehog mediates BDNF-induced neuroprotection against mitochondrial inhibitor 3-nitropropionic acid. Biochem Biophys Res Commun. 2009 Jul 17;385(1):112-7.

    • Tsai NW, Chang WN, Shaw CF, Jan CR, Huang CR, Chen SD, Chuang YC, Lee LH, Lu CH*. The value of leukocyte adhesion molecules in patients after ischemic stroke. J Neurol. 2009 Aug;256(8):1296-302.

    • Chuang YC*, Lin JW, Chen SD, Lin TK, Liou CW, Lu CH, Chang WN. Preservation of mitochondrial integrity and energy metabolism during experimental status epilepticus leads to neuronal apoptotic cell death in the hippocampus of the rat. Seizure. 2009 Jul;18(6):420-8.

    • Chen SD, Lin TK, Yang DI, Lee SY, Shaw FZ, Liou CW, Chuang YC*. Protective effects of peroxisome proliferator-activated receptors gamma coactivator-1alpha against neuronal cell death in the hippocampal CA1 subfield after transient global ischemia. J Neurosci Res. 2010 Feb 15;88(3):605-13.

    • Tsai NW, Chang WN, Shaw CF, Jan CR, Chang HW, Huang CR, Chen SD, Chuang YC, Lee LH, Lu CH*. Serial change in platelet activation markers with aspirin and clopidogrel after acute ischemic stroke. Clin Neuropharmacol. 2010 Jan-Feb;33(1):40-5.

    • Weng SW, Lin TK, Wang PW, Chen IY, Lee HC, Chen SD, Chuang YC, Liou CW*. Gly482Ser polymorphism in the peroxisome proliferator-activated receptor gamma coactivator-1alpha gene is associated with oxidative stress and abdominal obesity. Metabolism. 2010 Apr;59(4):581-6.

    • Lin TK, Liou CW, Chen SD, Chuang YC, Tiao MM, Wang PW, Chen JB, Chuang JH*. Mitochondrial dysfunction and biogenesis in the pathogenesis of Parkinson's disease. Chang Gung Med J. 2009 Nov-Dec;32(6):589-99. Review.

    • Chuang YC, Chen SD, Lin TK, Chang WN, Lu CH, Liou CW, Chan SH, Chang AY*. Transcriptional upregulation of nitric oxide synthase II by nuclear factor-kappaB promotes apoptotic neuronal cell death in the hippocampus following experimental status epilepticus. J Neurosci Res. 2010 Jul;88(9):1898-907.

    • Wu CL, Chen SD, Yin JH, Hwang CS, Yang DI*. Erythropoietin and sonic hedgehog mediate the neuroprotective effects of brain-derived neurotrophic factor against mitochondrial inhibition. Neurobiol Dis. 2010 Oct;40(1):146-154

    • Wu, C.L., Hwang, C.S., Chen, S.D., Yin, J.H., and Yang, D.I*. Neuroprotective mechanisms of brain-derived neurotrophic factor against 3-nitropropionic acid toxicity: Therapeutic implications for Huntington’s disease. Ann NY Acad Sci 2010 Jul;1201(1):8-12

    • Chen SD, Lin TK, Lin JW, Yang DI, Lee SY, Shaw FZ, Liou CW, Chuang YC*. Activation of Calcium/Calmodulin-Dependent Protein Kinase IV and Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Signaling Pathway Protects Neuronal Injury and Promotes Mitochondrial Biogenesis in The Hippocampal CA1 Subfield After Transient Global Ischemia. Journal of Neuroscience Research, 2010 Nov 88(14) 3144-3154.

    • Liou CW, Lin TK, Chen JB, Tiao MM, Weng SW, Chen SD, Chuang YC, Chuang JH, Wang PW*. Association between a common mitochondrial DNA D-loop polycytosine variant and alteration of mitochondrial copy number in human peripheral blood cells. J Med Genet. 2010 Nov;47(11):723-8

    • Chen SD, Chang AY, Chuang YC*. The Potential Role of Mitochondrial Dysfunction in Seizure-Associated Cell Death in the Hippocampus and Epileptogenesis. J Bioenerg Biomembr (2010) 42:461–465. (Cover story)

    • Tsai NW, Lin TK, Chen SD, Chang WN, Wang HC, Yang TM, Lin YJ, Jan CR, Huang CR, Liou CW, Lu CH*. The value of serial plasma nuclear and mitochondrial DNA levels in patients with acute ischemic stroke. Clin Chim Acta. 2011 Feb 20;412(5-6):476-9. 2010 Dec 3..

    • Tang CM, Hwang CS, Chen SD, Yang DI. Neuroprotective mechanisms of minocycline against sphingomyelinase/ceramide toxicity: Roles of Bcl-2 and thioredoxin. Free Radic Biol Med. 2011 Mar 15;50(6):710-21.

    • Chen SD, Yeh KH , Huang YH, Shaw FZ*. Effect of intracranial administration of ethosuximide in rats with spontaneous or pentylenetetrazol-induced spike-wave discharges. Epilepsia 2011 Jul;52(7):1311-8.

    • Tsai NW, Lin TK, Chang WN, Jan CR, Huang CR, Chen SD, Cheng KY, Chiang YF, Wang HC, Yang TM, Lin YJ, Lin WC, Chang HW, Lee LH, Lu CH. Statin pre-treatment is associated with lower platelet activity and favorable outcome in patients with acute non-cardio-embolic ischemic stroke. Crit Care. 2011 Jul 8;15(4):R163.

    • Chen SD*, Yang DI, Lin TK, Shaw FZ, Liou CW, Chuang YC*. Roles of Oxidative Stress, Apoptosis, PGC-1α and Mitochondrial Biogenesis in Cerebral Ischemia. Int. J. Mol. Sci. 2011, Oct; 12(10), 7199-7215

    • Chuang YC*, Chuang HY, Lin TK, Chang CC, Lu CH, Chang WN, Chen SD, Tan TY, Huang CR, Chan SH. Effects of long-term antiepileptic drug monotherapy on vascular risk factors and atherosclerosis. Epilepsia. 2012 Jan; 53(1): 120-8

    • Wu CL, Yin JH, Hwang CS, Chen SD, Yang DY, Yang DI*. c-Jun-dependent sulfiredoxin induction mediates BDNF protection against mitochondrial inhibition in rat cortical neurons. Neurobiol Dis. 2012 May;46(2):450-62.

    • Chang CC, Lui CC, Lee CC, Chen SD, Chang WN, Lu CH, Chen NC, Chang AY, Chan SH, Chuang YC*. Clinical significance of serological biomarkers and neuropsychological performances in patients with temporal lobe epilepsy. BMC Neurol. 2012 Mar 14;12(1):15.

    • Lin TK, Cheng CH, Chen SD, Liou CW, Huang CR, ChuangYC*. Mitochondrial Dysfunction and Oxidative Stress Promote Apoptotic Cell Death in the Striatum via Cytochrome c/ Caspase-3 Signaling Cascade Following Chronic Rotenone Intoxication in Rats. Int. J. Mol. Sci. 2012 July, 13, 8722-8739.

    • Chuang YC*, Lin TK, Huang HY, Chang WN, Liou CW, Chen SD*, Chang AY, Chan SH. Peroxisome proliferator-activated receptors gamma/mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus. J Neuroinflammation. 2012 Jul 31;9(1):184.

    • Chen SD, Yin JH, Hwang CS, Tang CM, Yang DI*. Anti-apoptotic and anti-oxidative mechanisms of minocycline against sphingomyelinase/ceramide neurotoxicity: implication in Alzheimer's disease and cerebral ischemia. Free Radic Res. 2012 Aug;46(8):940-50. Epub 2012 May 28..

    • Chen SD, Wu CL, Lin TK, Chuang YC, Yang DI*. Renin inhibitor aliskiren exerts neuroprotection against amyloid beta-peptide toxicity in rat cortical neurons. Neurochem Int. 2012 Aug;61(3):369-377.

    • Liou CW, Chen JB, Tiao MM, Weng SW, Huang TL, Chuang JH, Chen SD, Chuang YC, Lee WC, Lin TK*, Wang PW*. Mitochondrial DNA Coding and Control Region Variants as Genetic Risk Factors for Type 2 Diabetes Mellitus. Diabetes. 2012 Oct;61(10):2642-51. Aug 13.

    • Tsai NW, Lee LH, Huang CR, Chang WN, Chen SD, Wang HC, Lin YJ, Lin WC, Chiang YF, Lin TK, Cheng BC, Su YJ, Kung CT, Hung SH, Chang HW, Lu CH. The association of statin therapy and high-sensitivity C-reactive protein level for predicting clinical outcome in acute non-cardioembolic ischemic stroke. Clin Chim Acta. 2012 Nov 20;413(23-24):1861-5.

    • Huang HY, Lee HW, Chen SD, Shaw FZ. Lamotrigine ameliorates seizures and psychiatric comorbidity in a rat model of spontaneous absence epilepsy. Epilepsia. 2012 Nov;53(11):2005-14.

    • Lin TK, Lin HY, Chen SD, Chuang YC, Chuang JH, Wang PW, Huang ST, Tiao MM, Chen JB, Liou CW. The creation of cybrids harboring mitochondrial haplogroups in the taiwanese population of ethnic chinese background: an extensive in vitro tool for the study of mitochondrial genomic variations. Oxid Med Cell Longev. 2012;2012:824275.