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醫療團隊

專業的醫護人員，提供最佳的醫療服務

醫師介紹

  •

張文能醫師

1.CNS Infection(中樞神經系統感染症) 2.General Neurology(一般神經內科學) 3.頭痛症(如偏頭痛之先進治療) 4.中風(如中風之預防及中風後肌張力過強的肉毒桿菌素注射) 5.多發性硬化症 (multiple sclerosis) 6.視神經脊髓炎 (neuromyelitis optica)之治療 7.肉毒桿菌素注射 8.多汗症(肉毒桿菌素注射治療)
  • 國語,英語,閩南語
  • 教授
醫師網路掛號
直接點選進入醫師網路掛號畫面
醫師資歷
  • 現職
    • 高雄長庚醫院 神經內科部 一般神經科 顧問級主治醫師
  • 學歷
    • 中國醫藥學院 醫學系
  • 學會與認證
    • 台灣神經內科專科
  • 論文及期刊發表
    • Su YJ, Cheng TT, Chen CJ, Chang WN, Tsai NW, Kung CT, Wang HC, Lin WC, Huang CC, Chang YT, Su CM, Chiang YF, Cheng BC, Lin YJ, Lu CH: Investigation of caspase-dependent mitochondrial apoptotic pathway in mononuclear cells of patients with systemic lupus erythematosus. J Transl Med 2014;12: 303.

    • Chang CC, Hsiao IT, Huang SH, Lui CC, Yen TC, Chang WN, Huang CW, Hsieh CJ, Chang YY, Lin KJ: 18F-FP-(+)-DTBZ positron emission tomography detection of monoaminergic deficient network in patients with carbon monoxide related parkinsonism. Eur J Neurol 2015;22: 845-852.

    • Tsai TH, Lu CH, Wallace CC, Chang WN, Chen SF, Huang CR, Tsai NW, Lan MY, Sung PH, Liu CF, Yip HK: Erythropoietin improves long-term neurological outcome in acute ischemic stroke patients: a randomized, prospective, placebo-controlled clinical trial. Crit Care 2015;19:49.

    • Chang YT, Huang CW, Chang YH, Chen NC, Lin KJ, Yan TC, Chang WN, Chen SF, Lui CC, Lin PH, Chang CC. Amyloid burden in the hippocampus and default mode network: relationships with gray matter volume and cognitive performance in mild state Alzheimer disease. Medicine (Baltimore) 2015;94:e763..

    • Chang YT, Chang WN, Tsai NW, Huang CC, Wang HC, Kung CT, Su YJ, Lin WC, Cheng BC, Su CM, Chiang YF, Lu CH: Link between cerebral blood flow and autonomic function in survivors of internal carotic artery occlusion. J Neurol Sci 2015;353: 143-148.

    • Chen NC, Huang CW, Huang SH, Chang WN, Chang YT, Lui CC, Lin PH, Lee CC, Chang YH, Chang CC: Cognitive severity-specific neuronal degenerative network in charcoal burning suicide-related carbon monoxide intoxication: a multimodality neuroimaging study in Taiwan. Medicine (Baltimore) 2015;94:e783.

    • Chang YT, Chang WN, Tsai NW, Cheng KY, Huang CC, Kung CT, Su YJ, Lin WC, Cheng BC, Su CM, Chiang YF, Lu CH: Clinical features associated with frozen shoulder syndrome in Parkinson’s disease. Parkinsons Dis 2015;2015:232958.

    • Kung CT, Su CM, Chen CT, Cheng HH, Chang MW, Hung CW, Hung SC, Chang WN, Tsai NW, Wang HC, Su YJ, Huang CC, Lin WC, Cheng BC, Chang YT, Lu CH: Circulating endothelial progenitor cells may predict outcomes in adult patients with severe sepsis in the emergency department. Clin Chim Acta 2016;455: 1-6.

    • Kung CT, Su CM, Chen CT, Cheng HH, Chang MW, Hung CW, Hung SC, Chang WN, Tsai NW, Wang HC, Su YJ, Huang CC, Lin WC, Cheng BC, Chang YT, Lu CH: Circulating endothelial progenitor cells may predict outcomes in adult patients with severe sepsis in the emergency department. Clin Chim Acta 2016;455: 1-6.

    • Chang YT, Huang CW, Chen NC, Lin KJ, Huang SH, Chang YH, Hsu SW, Chang WN, Lui CC. Hsu CW, Chang CC: Prefrontal lobe brain reserve capacity with resistance to higher global amyloid load and white matter hyperintensity burden in mild stage Alzheimer disease. Plos One 2016;11:e0149056.

    • Lu YT, Chang WN, Chang CC, Lu CH, Chen NC, Huang CW, Lin WC, Chang YT: insula volume and salience network are associated with memory decline in Parkinson disease: complememtary analyses of voxel-based morphometry versus volume of interest. Parkinsons Dis 2016;2016:2939528.

    • Su CM, Cheng HH, Hung CW, Hsiao SY, Tsai NW, Chang WN, Wang HC, Lin WC, Cheng BC, Su YJ, Chang YT, Kung CT, Lu CH: The value of serial serum cell adhesion molecules in predicting acute kidney injury after severe sepsis in adults. Clin Chim Acta 2016;457: 86-91.

    • Chang CC, Hsu JL, Chang WN, Huang SH, Huang CW, Chang YT, Chen NC, Lui CC, Lee CC, Hsu SW: Metabolic covariant network in relation to nigrostriatal degeneration in carbon monoxide intoxication-related parkinsonism. Front neurosci 2016;10:187.

    • Chang YT, Huang CW, Chen NC, Lin KJ, Huang SH, Chang WN, Hsu SW, Hsu CW, Chen HH, Chang CC: Hippocampal amyloid burden with downstream fusiform gyrus atrophy correlates with face matching task scores in early Alzheimer’s disease. Front Aging Neurosci 2016; 8:145.

    • Lin PH, Chen HH, Chen NC, Chang WN, Huang CW, Chang YT, Hsu SW, Hsu CW, Chang CC: Anatomical correlates of non-verbal perception in dementia patients. Front Aging Neurosci 2016; 8: 207

    • Chang YT, Lin HC, Chang WN, Tsai NW, Huang CC, Wang HC, Kung CT, Su YJ, Lin WC, Cheng BC, Su CM, Chen TY, Chiang YF, Lu CH: Impact of inflammation and oxidase stress on carotid intima-media thickness in obstructive sleep apnea patients without metabolic syndrome. J Sleep Res 2017; 26: 151-158.

    • Huang CW, Hsu SW, Tsai SJ, Chen NC, Liu ME, Lee CC, Huang SH, Chang WN, Chang YT, Tsai WC, Chang CC: Genetic effect of interleukin-1 beta (C-511T) polymorphism on the structural covariance network and whire matter integrity in Alzheimer’s disease. J Neuroinflammation 2017; 14: 12

    • Tsai MH, Chan CK, Chang YC, Yu YT, Chuang ST, Fan WL, Li SC, Fu TY, Chang WN, Liou CW, Chuang YC, Ng CC, Hwang DY, Lim KS: DEPDC5 mutations ub familial and sporadic focal epilepsy. Clin Genet 2017; 10:1111

    • Chang YT, Hsu SW, Tsai SJ, Chang YT, Huang CW, Liu ME, Chen NC, Chang WN, Hsu JL, Lee CC, Chang CC: Genetic effect of MTHFR C677T polymorphism on the structural covariance network and white matter integrity in Alzheimer’s disease. Hum Brain Mapp 2017; 38(6): 3039-3051.

    • Lien CY, Huang CR, Tsai WC, Hsu CW, Tsai NW, Chang CC, Lu CH, Chien CC, Chang WN*: Epidemiologic trend of adult bacterial meningitis in southern Taiwan (2006-2015). J Clin Neurosci 2017; 42: 59-65.

    • Chen CT, Chang CC, Chang WN, Tsai NM, Huang CC, Chang YT, Wang HC, Kung CT, Su YJ, Lin WC, Cheng BC, Su CM, Hsiao SY, Hsu CW, Lu CH: Neuropsychiatric symptoms in Alzheimer’s disease: association with caregiver burden and treatment outcomes. QJM 2017; 110(9): 565-570.

    • Fang YN, Tong MS, Sung PH, Chen YL, Chen CH, Tsai NW, Huang CJ, Chang YT, Chen SF, Chang WN, Lu CH, Yip HK: Higher neutrophil counts and neutrophil-to-lymphocyte ratio predict prognostic outcomes in patients after non-atrial fribillation-caused ischemic stroke. Biomed J 2017; 40: 154-162.

    • Lee CC, Hsu SW, Huang CW, Chang WN, Chen SF, Wu MK, Chang CC, Hwang LC, Chen PC: effects of homocysteine on white matter diffusion parameters in Alzheimer’s disease. BMC Neurol 2017; 17(1): 192.

    • Lee JJ, Lien CY, Huang CR, Tsai NW, Chang CC, Lu CH, Chang WN*: Clinical Characteristics and Therapeutic Outcomes of Postneurosurgical Bacterial Meningitis in Elderly Patients over 65: A Hospital-based Study. Acta Neurol Taiwan 2017; 26; 144-153.

    • Hung CW, Lin WC, Chang WN, Su TM, Kung CT, Tsai NW, Wang HC, Huang CC, Cheng BC, Su YJ, Chang YT, Su CM, Hsiao SY, Lu CH: Risk factors and outcomes of cerebrospinal fluid overdrainage in HIV-negative patients with cryptococcal meningitis after the ventriculoperitoneal shunting procedure. J Microbiol Immuno Infect 2018; 51(4): 545-551.

    • Chang CC, Tsai SJ, Chen NC, Huang CW, Hsu SW, Chang YT, Liu ME, Chang WN, Tsai WC, Lee CC: Catechol-O-Methyltransferase Val158Met polymorphism on striatum structural covariance networks in Alzheimer’s disease. Mol Neurobiol 2018; 55(6): 4637-4649.

    • Sun TK, Chen YY, Huang SH, Hsu SW, Lee CC, Chang WN, Huang CW, Lui CC, Lien CY, Cheng JL, Chang CC: Neurotoxicity of carbon monoxide targets caudate-mediated dopaminergic system. Neurotoxicology 2018; 65: 272-279.

    • Huang CR, Lien CY, Tsai WC, Lai WA, Hsu CW, Tsai NW, Chang CC, Lu CH, Chien CC, Chang WN*: The clinical characteristics of adult bacterial meningitis caused by non-Pseudomonas (Ps.) aeruginosa Pseudomonas species: a clinical comparison with Ps, aeruginosa meningitis. Kaohsiung J Med Sci 2018; 34: 49-55.

    • Huang CR, Lien CY, Tsai WC, Lai WA, Hsu CW, Tsai NW, Chang CC, Lu CH, Chien CC, Chang WN*: The clinical characteristics of adult bacterial meningitis caused by non-Pseudomonas (Ps.) aeruginosa Pseudomonas species: a clinical comparison with Ps, aeruginosa meningitis. Kaohsiung J Med Sci 2018; 34: 49-55.

    • Huang CW, Hsu SW, Chang YT, Huang SH, Huang YC, Lee CC, Chang WN, Lui CC, Chen NC, Chang CC: Cerebral perfusion insufficiency and relationships with cognitive deficits in Alzheimer’s disease: a multiparametric neuroimaging study. Sci Rep 2018; 8(1): 1541.

    • Chang YT, Lu CH, Wu MK, Hsu SW, Huang CW, Chang WN, Lien CY, Chang CC: Salience network and depressive severities in Parkinson’s disease with mild cognitive impairment: a structural covariance network analysis. Front Aging Neurosci 2018; 9: 417.

    • Lee JJ, Lien CY, Chien CC, Huang CR, Tsai NW, Chang CC, Lu CH, Chang WN*: Anaerobic bacterial meningitis in adults. J Clin Neurosci 2018; 50: 45-50.

    • Chang CC, Chang YT, Huang CW, Tsai SJ, Hsu SW, Huang SH, Lee CC, Chang WN, Lui CC, Lien CY: Associations of Bcl-2 rs956572 genotype groups in the structural covariance network in early-state Alzheimer’s disease. Alzheimers Res Ther 2018; 10(1): 17

    • Chang YT, Huang CW, Huang SH, Hsu SW, Chang WN, Chang CC: Genetic interaction is associated with lower metabolic connectivity and memory impairment in clinically mild Alzheimer’s disease. Genes Brain Behav 2018; 8: e12490.

    • Lien CY, Lee JJ, Chien CC, Huang CR, Lu CH, Chang WN*: Clinical characteristics of Citrobacter meningitis in adults: high incidence in patients with a postneurosurgical state and strains not susceptible to third-generation cephalosporins. J Clin Neurosci 2018; 54: 83-87.

    • Lee JJ, Chang WN, Hsu JL, Huang CW, Chang YT, Hsu SW, Huang SH, Lee CC, Lien CY, Chang CC: Diffusion kurtosis imaging as a neuroimaging biomarker in patients with carbon monoxide intoxication. Neurotoxicology 2018; 68: 38-46.

    • Tsai MH, Chan CK, Chang YC, Lin CH, Liou CW, Chang WN, Ng CC, Lim KS, Hwang DY: Molecular genetic characterization of patients with focal epilepsy using a customized targeted resequencing gene panel. Front Neurol 2018; 9: 515.

    • Tsai WC, Lien CY, Lee JJ, Lin WC, Hsu CW, Huang CR, Tsai NW, Chang CC, Lu CH, Chang WN*: The prognostic factors of HIV-negative adult cryptococcal meningitis with a focus on cranial MRI-based neuroimaging findings. J Clin neurosci 2018; 55: 57-61

    • Chang HI, Chang YT, Tsai SJ3, Huang CW, Hsu SW, Liu ME, Chang WN, Lien CY, Huang SH, Lee CC, Chang CC: MAOA-VNTR Genotype Effects on Ventral Striatum-Hippocampus Network in Alzheimer's Disease: Analysis Using Structural Covariance Network and Correlation with Neurobehavior Performance. Mol Neurobiol 2019; 56: 4518-4529.

    • Lai YR, Lin JR, Chang WN, Tsai NW, Huang CC, Wang HC, Su YJ, Lin WC, Cheng BC, Su CM, Hsiao SY, Kuo CE0, Lu CH: J Clin Neurosci 2019; 61: 54-58.

    • Chang YT, Mori E, Suzuki M, Ikeda M, Huang CW, Lee JJ, Chang WN, Chang CC: APOE-MS4A genetic interactions are associated with executive dysfunction and network abnormality in clinically mild Alzheimer's disease. Neuroimage Clin 2019; 21: 1010621.

    • Lee JJ, Tsai MH, Lien CY, Huang YJ, Chang WN*: Intra-family phenotype variations in familial neuromyelitis optica spectrum disorders. Mult Scler Relat Disorder 2019; 30: 57-62.

    • Tsai WC, Lien CY, Lee JJ, Hsiao WC, Huang CR, Tsai NW, Chang CC, Lu CH, Chang WN*: The clinical characteristics and therapeutic outcomes of cryptococcal meningitis in elderly patients: a hospital-based study. BMC Geriatr 2019; 19: 91.

    • Lien CY, Lee JJ, Tsai WC, Chen SY, Huang CR, Chien CC, Lu CH, Chang WN*: The clinical characteristics of spontaneous Gram-negative bacterial meningitis in adults: A hospital-based study. J Clin Neurosci 2019; 64: 101-105.

    • Tsai WC, Lin HC, Lai YR, Hsu CW, Huang CC, Wang HC, Su CM, Su YJ, Lin WC, Cheng BC, Chang WN, Lu CH, Tsai NW: The Effect of Stroke Subtypes on Baroreceptor Sensitivity, a Predict for Acute Stroke Outcome. Biomed Res Int 2019; 2019: 7614828.

    • 8. Chang YT, Kazui H, Ikeda M, Huang CW, Huang SH, Hsu SW, Chang WN, Chang CC: Genetic Interaction of APOE and FGF1 is Associated with Memory Impairment and Hippocampal Atrophy in Alzheimer's Disease. Aging Dis 2019; 10: 510-519.

    • Tsai WC, Lien CY, Lee JJ, Huang CR, Tsai NW, Chang CC, Lu CH, Chang WN*: The clinical characteristics of adult cryptococcal meningitis patients who died within one year of treatment with a focus on those with early mortality. 2019; 67: 80-84.

    • Tsai WC, Lien CY, Lee JJ, Huang CR, Tsai NW, Chang CC, Lu CH, Chang WN*: The clinical characteristics of adult cryptococcal meningitis patients who died within one year of treatment with a focus on those with early mortality. 2019; 67: 80-84.

    • Yang TP, Chang WN, Lu CH, Lien CY: Klebsiella pneumoniae brain abscesses in an elderly patient without clinically evident neurological signs and symptoms. Acta Neurol Taiwan 2019; 15: 12-16.

    • Hsu CW, Tsai WC, Lien CY, Lee JJ, Chang WN*: The clinical characteristics, implicated pathogens and therapeutic outcomes of culture-proven septic cavernous sinus thrombosis. J Clin Neurosci 2019; 68: 111-116.

    • Wang PW, Lin TY, Hung YC, Chang WN, Yang PM, Chen MH, Chen MH, Yeh CT, Pan TL: Characterization of fibrinogen as a key modulator in patients with Wilson’s disease with functional proteomic tool. Int J Mol Sci 2019; 20; 4528.