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醫師介紹

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陳瓊美醫師

巴金森氏症、小腦萎縮、亨丁頓舞蹈症、動作障礙疾病、遺傳性神經性疾病
  • 國語,英語
  • 教授
醫師網路掛號
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醫師資歷
  • 現職
    • 林口長庚紀念醫院神經內科教授級主治醫師
  • 學歷
    • 台北醫學院醫學系學士
    • 英國格拉斯哥大學醫學博士
  • 經歷
    • 林口長庚紀念醫院神經內科主治醫師
    • 林口長庚紀念醫院神經內科住院醫師
  • 學會與認證
    • 台灣神經學學會
    • 台灣動作障礙學會
    • 神經科專科醫師證書
    • 神經重症專科醫師證書
  • 論文及期刊發表
    • The Role of NRF2 in Trinucleotide Repeat Expansion Disorders.
      Antioxidants. Jun 2024, 13, 649. https://doi.org/10.3390/antiox13060649.
      Kuo-Hsuan Chang, Chiung-Mei Chen*.
    • Investigating the therapeutic effects of novel compounds targeting inflammatory IL-1β and IL-6 signaling pathways in spinocerebellar ataxia type 3.
      Eur J Pharmacol. 2024 Mar 15:967:176370. doi: 10.1016/j.ejphar.2024.176370. Epub 2024 Feb 5.
      I-Cheng Chen, Wan-Ling Chen, Kuo-Hsuan Chang, Jun-Wei Lee, Te-Hsien Lin, Wenwei Lin, Chiung-Mei Chen*, Guey-Jen Lee-Chen*.
    • Identification of blood metabolic biomarkers associated with diabetic distal symmetric sensorimotor polyneuropathy in patients with type 2 diabetes mellitus.
      J Peripher Nerv Syst. 2023 Dec;28(4):651-663. doi: 10.1111/jns.12600. Epub 2023 Oct 21.
      Kuo-Hsuan Chang, Chiung-Mei Chen, Chia-Ni Lin, Sung-Sheng Tsai, Rong-Kuo Lyu, Chun-Che Chu, Long-Sun Ro, Ming-Feng Liao, Hong-Shiu Chang, Yi-Ching Weng, Jawl-Shan Hwang, Hung-Chou Kuo*.
    • Coumarin-chalcone hybrid LM-021 and indole derivative NC009-1 targeting inflammation and oxidative stress to protect BE(2)-M17 cells against α-synuclein toxicity.
      Aging (Albany NY). 2023 Aug 11;15(16):8061-8089. doi: 10.18632/aging.204954. Epub 2023 Aug 11.
      Pei-Ning Yang, Wan-Ling Chen, Jun-Wei Lee, Chih-Hsin Lin, Yi-Ru Chen, Chung-Yin Lin, Wenwei Lin, Ching-Fa Yao, Yih-Ru Wu, Kuo-Hsuan Chang, Chiung-Mei Chen*, Guey-Jen Lee-Chen*.
    • Increased 18 F-FDG uptake in denervated muscles in a case of Parsonage-Turner syndrome.
      BMC Neurol. 2023 Jul 26;23(1):280. doi: 10.1186/s12883-023-03328-x.
      Ping-I Chiang, Chiung-Mei Chen*.
    • Ganglioside-focused Glycan Array Reveals Abnormal Anti-GD1b Auto-antibody in Plasma of Preclinical Huntington's Disease.
      Mol Neurobiol. 2023 Jul;60(7):3873-3882. doi: 10.1007/s12035-023-03307-w. Epub 2023 Mar 28.
      Tien-Wei Lin, Jung-Kai Chang, Yih-Ru Wu, Tsung-Hsien Sun, Yang-Yu Cheng, Chien-Tai Ren, Mei-Hung Pan, Jin-Lin Wu, Kuo-Hsuan Chang, Hwai-I Yang, Chiung-Mei Chen*, Chung-Yi Wu*, Yun-Ru Chen*.
    • Upregulation of APAF1 and CSF1R in Peripheral Blood Mononuclear Cells of Parkinson's Disease.
      Int J Mol Sci. 2023 Apr 12;24(8):7095. doi: 10.3390/ijms24087095.
      Kuo-Hsuan Chang, Chia-Hsin Liu, Yi-Ru Wang, Yen-Shi Lo, Chun-Wei Chang, Hsiu-Chuan Wu, Chiung-Mei Chen*.
    • Alternations of Lipoprotein Profiles in the Plasma as Biomarkers of Huntington's Disease.
      Cells. 2023 Jan 20;12(3):385. doi: 10.3390/cells12030385.
      Kuo-Hsuan Chang, Mei-Ling Cheng, Chi-Jen Lo, Chun-Ming Fan, Yih-Ru Wu, Chiung-Mei Chen*.
    • Using ΔK280 TauRD Folding Reporter Cells to Screen TRKB Agonists as Alzheimer's Disease Treatment Strategy.
      Biomolecules. 2023 Jan 23;13(2):219. doi: 10.3390/biom13020219.
      Zheng-Kui Weng, Te-Hsien Lin, Kuo-Hsuan Chang, Ya-Jen Chiu, Chih-Hsin Lin, Pei-Hsuan Tseng, Ying-Chieh Sun, Wenwei Lin, Guey-Jen Lee-Chen*, Chiung-Mei Chen*.
    • Phosphorylated α-synuclein in diluted human serum as a biomarker for Parkinson's disease.
      Biomed J. 2022 Dec;45(6):914-922. doi: 10.1016/j.bj.2021.12.010. Epub 2021 Dec 31.
      Wei-Ru Chen, Jin-Chung Chen, Sheng-Yi Chang, Chi-Tse Chao, Yih-Ru Wu*, Chiung-Mei Chen*, Chien Chou*.
    • Neuroprotective Action of Coumarin Derivatives through Activation of TRKB-CREB-BDNF Pathway and Reduction of Caspase Activity in Neuronal Cells Expressing Pro-Aggregated Tau Protein.
      Int J Mol Sci. 2022 Oct 22;23(21):12734. doi: 10.3390/ijms232112734.
      Te-Hsien Lin, Kuo-Hsuan Chang, Ya-Jen Chiu, Zheng-Kui Weng, Ying-Chieh Sun, Wenwei Lin, Guey-Jen Lee-Chen*, Chiung-Mei Chen*.
    • Novel TRKB agonists activate TRKB and downstream ERK and AKT signaling to protect Aβ-GFP SH-SY5Y cells against Aβ toxicity.
      Aging (Albany NY). 2022 Sep 26;14(18):7568-7586. doi: 10.18632/aging.204306. Epub 2022 Sep 26.
      Ya-Jen Chiu, Te-Hsien Lin, Kuo-Hsuan Chang, Wenwei Lin, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Chiung-Mei Chen*, Ying-Chieh Sun*, Guey-Jen Lee-Chen*.
    • Evaluating the Different Stages of Parkinson's Disease Using Electroencephalography With Holo-Hilbert Spectral Analysis.
      Front Aging Neurosci. 2022 May 10:14:832637. doi: 10.3389/fnagi.2022.832637. eCollection 2022.
      Kuo-Hsuan Chang, Isobel Timothea French, Wei-Kuang Liang, Yen-Shi Lo, Yi-Ru Wang, Mei-Ling Cheng, Norden E Huang, Hsiu-Chuan Wu, Siew-Na Lim, Chiung-Mei Chen*, Chi-Hung Juan*.
    • Major Bleeding Risk in Atrial Fibrillation Patients Co-Medicated With Non-Vitamin K Oral Anticoagulants and Antipsychotics.
      Front Pharmacol. 2022 Apr 14:13:819878. doi: 10.3389/fphar.2022.819878. eCollection 2022.
      Chiung-Mei Chen, Kuo-Hsuan Chang, Chun-Li Wang, Hui-Tzu Tu, Yu-Tung Huang, Hsiu-Chuan Wu, Chien-Hung Chang, Shang-Hung Chang*.
    • Focused Ultrasound-Induced Blood–Brain Barrier Opening Enhanced -Synuclein Expression in Mice for Modeling Parkinson's Disease.
      Pharmaceutics. 2022 Feb 18;14(2):444. doi: 10.3390/pharmaceutics14020444.
      Chung-Yin Lin, Ching-Yun Huang, Chiung-Mei Chen*, Hao-Li Liu*.
    • A Novel SETX Mutation in a Taiwanese Patient with Autosomal Recessive Cerebellar Ataxia Detected by Targeted Next-Generation Sequencing, and a Literature Review.
      Brain Sci. 2022 Jan 28;12(2):173. doi: 10.3390/brainsci12020173.
      Ping-I Chiang, Ting-Wei Liao, Chiung-Mei Chen*.
    • Major Bleeding Risk in Patients With Non-valvular Atrial Fibrillation Concurrently Taking Direct Oral Anticoagulants and Antidepressants.
      Front Aging Neurosci. 2022 Feb 4:14:791285. doi: 10.3389/fnagi.2022.791285. eCollection 2022.
      Kuo-Hsuan Chang, Chiung-Mei Chen, Chun-Li Wang, Hui-Tzu Tu, Yu-Tung Huang, Hsiu-Chuan Wu, Chien-Hung Chang, Shang-Hung Chang*.
    • Alterations of Sphingolipid and Phospholipid Pathways and Ornithine Level in the Plasma as Biomarkers of Parkinson's Disease.
      Cells. 2022 Jan 24;11(3):395. doi: 10.3390/cells11030395.
      Kuo-Hsuan Chang, Mei-Ling Cheng, Hsiang-Yu Tang, Cheng-Yu Huang, Hsiu-Chuan Wu, Chiung-Mei Chen*.
    • Flavones 7,8-DHF, Quercetin, and Apigenin Against Tau Toxicity via Activation of TRKB Signaling in ΔK280 TauRD-DsRed SH-SY5Y Cells.
      Front Aging Neurosci. 2021 Dec 15:13:758895. doi: 10.3389/fnagi.2021.758895. eCollection 2021.
      Ni-Ni Chiang, Te-Hsien Lin, Yu-Shan Teng, Ying-Chieh Sun, Kuo-Hsuan Chang, Chung-Yin Lin, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Chiung-Mei Chen*, Guey-Jen Lee-Chen*.
    • Alterations of Plasma Galectin-3 and C3 Levels in Patients with Parkinson's Disease.
      Brain Sci. 2021 Nov 15;11(11):1515. doi: 10.3390/brainsci11111515.
      Hsiu-Chuan Wu, Kuo-Hsuan Chang, Mu-Chun Chiang, Chiung-Mei Chen*.
    • Multi-Target Effects of Novel Synthetic Coumarin Derivatives Protecting Aβ-GFP SH-SY5Y Cells against A Toxicity.
      Cells. 2021 Nov 9;10(11):3095. doi: 10.3390/cells10113095.
      Ching-Chia Huang, Kuo-Hsuan Chang, Ya-Jen Chiu, Yi-Ru Chen, Tsai-Hui Lung, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Ying-Chieh Sun, Chiung-Mei Chen*, Wenwei Lin*, Guey-Jen Lee-Chen*.
    • Novel Synthetic Coumarin-Chalcone Derivative (E)-3-(3-(4- (Dimethylamino)Phenyl)Acryloyl)-4-Hydroxy-2H-Chromen-2- One Activates CREB-Mediated Neuroprotection in Aβ and Tau Cell Models of Alzheimer's Disease.
      Oxid Med Cell Longev. 2021 Nov 13:2021:3058861. doi: 10.1155/2021/3058861. eCollection 2021.
      Ya-Jen Chiu, Te-Hsien Lin, Chiung-Mei Chen, Chih-Hsin Lin, Yu-Shan Teng, Chung-Yin Lin, Ying-Chieh Sun, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Guey-Jen Lee-Chen*, Wenwei Lin*, Kuo-Hsuan Chang*.
    • Assessing Plasma Levels of α-Synuclein and Neurofilament Light Chain by Different Blood Preparation Methods.
      Front Aging Neurosci. 2021 Nov 8:13:759182. doi: 10.3389/fnagi.2021.759182. eCollection 2021.
      Kuo-Hsuan Chang, Kou-Chen Liu, Chao-Sung Lai, Shieh-Yueh Yang, Chiung-Mei Chen*.
    • Fixel-Based Analysis Effectively Identifies White Matter Tract Degeneration in Huntington's Disease.
      Front Neurosci. 2021 Sep 13:15:711651. doi: 10.3389/fnins.2021.711651. eCollection 2021.
      Sher Li Oh, Chiung-Mei Chen, Yih-Ru Wu, Maria Valdes Hernandez, Chih-Chien Tsai, Jur-Shan Cheng, Yao-Liang Chen, Yi-Ming Wu, Yu-Chun Lin, Jiun-Jie Wang*.
    • Polymorphisms of Interleukin-6 and Interleukin-8 Are Not Associated with Parkinson's Disease in Taiwan.
      Brain Sci. 2021 Jun 9;11(6):768. doi: 10.3390/brainsci11060768.
      Tsai-Wei Liu, Yih-Ru Wu, Yi-Chun Chen, Hon-Chung Fung, Chiung-Mei Chen*.
    • Fibroblast Growth Factor 20 Gene Polymorphism in Parkinson's Disease in Asian Population: A Meta-Analysis.
      Genes (Basel). 2021 Apr 29;12(5):674. doi: 10.3390/genes12050674.
      Han-Lin Chiang, Yih-Ru Wu, Yi-Chun Chen, Hon-Chung Fung, Chiung-Mei Chen*.
    • Reappraisal of the incidence, various types and risk factors of malignancies in patients with dermatomyositis and polymyositis in Taiwan.
      Sci Rep. 2021 Feb 25;11(1):4545. doi: 10.1038/s41598-021-83729-5.
      Jung-Lung Hsu#, Ming-Feng Liao#, Chun-Che Chu, Hung-Chou Kuo, Rong-Kuo Lyu, Hong-Shiu Chang, Chiung-Mei Chen, Yih-Ru Wu, Kuo-Hsuan Chang, Yi-Ching Weng, Chun-Wei Chang, Hsing-I Chiang, Chih-Kuang Cheng, Pai-Wei Lee, Chin-Chang Huang, Long-Sun Ro*.
    • Pathomechanism Characterization and Potential Therapeutics Identification for Parkinson's Disease Targeting Neuroinflammation.
      Int J Mol Sci. 2021 Jan 21;22(3):1062. doi: 10.3390/ijms22031062.
      Chiung-Mei Chen, Chien-Yu Yen, Wan-Ling Chen, Chih-Hsin Lin, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Chen*.
    • X-linked adrenoleukodystrophy caused by a novel mutation presenting with various phenotypes in a Taiwanese family.
      Clin Chim Acta. 2021 Jan 8;514:100-106. doi: 10.1016/j.cca.2020.12.017. Online ahead of print.
      Chia-Yin Chien, Kuo-Hsuan Chang, Chiung-Mei Chen*.
    • Association of SOD2 p.V16A polymorphism with Parkinson's disease: A meta-analysis in Han Chinese.
      J Formos Med Assoc. 2021 Jan;120(1 Pt 2):501-507. doi: 10.1016/j.jfma.2020.06.023. Epub 2020 Jun 30.
      Yih-Ru Wu, Kuo-Hsuan Chang, Chih-Ying Chao, Chih-Hsin Lin, Yi-Chun Chen, Tsai-Wei Liu, Guey-Jen Lee-Chen, Chiung-Mei Chen*.
    • Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation.
      Aging (Albany NY). 2020 Nov 10;12(23):23619-23646. doi: 10.18632/aging.103700. Epub 2020 Nov 10.
      Ya-Jen Chiu, Shu-An Lin, Wan-Ling Chen, Te-Hsien Lin, Chih-Hsin Lin, Ching-Fa Yao, Wenwei Lin, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Chen, Chiung-Mei Chen*.
    • Differences in Clinical Presentation of Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease According to Sex and Education Level.
      J Alzheimers Dis. 2020;78(2):711-719. doi: 10.3233/JAD-200507.
      Kuo-Hsuan Chang, Chin-Chang Huang, Chiung-Mei Chen, Hsiu-Chuan Wu, Hung-Chou Kuo*.
    • Rare VPS35 A320V Variant in Taiwanese Parkinson's Disease Indicates Disrupted CI-MPR Sorting and Impaired Mitochondrial Morphology.
      Brain Sci. 2020 Oct 27;10(11):783. doi: 10.3390/brainsci10110783.
      Yih-Ru Wu, Chih-Hsin Lin, Chih-Ying Chao, Chia-Wen Chang, Chiung-Mei Chen*, Guey-Jen Lee-Chen*.
    • Serum levels of cell adhesion molecules in patients with neuromyelitis optica spectrum disorder.
      Ann Clin Transl Neurol. 2020 Oct;7(10):1854-1861. doi: 10.1002/acn3.51167. Epub 2020 Aug 28.
      Bao-Luen Chang, Long-Sun Ro, Chiung-Mei Chen, Yen-Shi Lo, Rong-Kuo Lyu, Hung-Chou Kuo, Ming-Feng Liao, Chun-Wei Chang, Hong-Shiu Chang, Ching-Chang Huang, Yih-Ru Wu, Chun-Che Chu, Yi-Ching Weng, Kuo-Hsuan Chang*.
    • Lactulose and Melibiose Attenuate MPTP-Induced Parkinson's Disease in Mice by Inhibition of Oxidative Stress, Reduction of Neuroinflammation and Up-Regulation of Autophagy.
      Front Aging Neurosci. 2020 Jul 24;12:226. doi: 10.3389/fnagi.2020.00226. eCollection 2020.
      Chih-Hsin Lin, Pei-Cih Wei, Chiung-Mei Chen, Yu-Ting Huang, Jia-Lan Lin, Yen-Shi Lo, Jia-Li Lin, Chung-Yin Lin, Yih-Ru Wu, Kuo-Hsuan Chang*, Guey-Jen Lee-Chen*.
    • Exploration of multi-target effects of 3-benzoyl-5-hydroxychromen-2-one in Alzheimer's disease cell and mouse models.
      Aging Cell. 2020 Jul;19(7):e13169. doi: 10.1111/acel.13169. Epub 2020 Jun 4.
      Te-Hsien Lin, Ya-Jen Chiu, Chih-Hsin Lin, Chung-Yin Lin, Chih-Ying Chao, Yu-Chieh Chen, Shu-Mei Yang, Wenwei Lin, Hsiu Mei Hsieh-Li, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Chen, Chiung-Mei Chen*.
    • The Role of Oxidative Stress in Parkinson's Disease.
      Antioxidants 2020, 9, 597; doi:10.3390/antiox9070597.
      Kuo?Hsuan Chang and Chiung?Mei Chen*.
    • Diabetic Distal Symmetrical Polyneuropathy: Correlation of Clinical, Laboratory, and Electrophysiologic Studies in Patients with Type 2 Diabetes Mellitus.
      J Diabetes Res. 2020 Jul 3;2020:6356459. doi: 10.1155/2020/6356459. eCollection 2020.
      Yi-Ching Weng, Sung-Sheng Tsai, Rong-Kuo Lyu, Chun-Che Chu, Long-Sun Ro, Ming-Feng Liao, Hong-Shiu Chang, Chiung-Mei Chen, Jawl-Shan Hwang, Hung-Chou Kuo*.
    • Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability.
      Cells. 2020 May 16;9(5):1230. doi: 10.3390/cells9051230.
      Chiung Mei Chen, Chih-Hsin Lin, Yih-Ru Wu, Chien-Yu Yen, Yu-Ting Huang, Jia-Lan Lin, Chung-Yin Lin, Wan-Ling Chen, Chih-Ying Chao, Guey-Jen Lee-Chen*, Ming-Tsan Su*, Kuo-Hsuan Chang*.
    • New Synthetic 3-Benzoyl-5-Hydroxy-2 H-Chromen-2-One (LM-031) Inhibits Polyglutamine Aggregation and Promotes Neurite Outgrowth through Enhancement of CREB, NRF2, and Reduction of AMPK α in SCA17 Cell Models.
      Oxid Med Cell Longev. 2020 Apr 22;2020:3129497. doi: 10.1155/2020/3129497. eCollection 2020.
      Chiung-Mei Chen, Wan-Ling Chen, Shu-Ting Yang, Te-Hsien Lin, Shu-Mei Yang, Wenwei Lin, Chih-Ying Chao, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Chen*.
    • Genetic Analysis of EGLN1 C127S Variant in Taiwanese Parkinson's Disease.
      Parkinsons Dis. 2020 Apr 25;2020:9582317. doi: 10.1155/2020/9582317. eCollection 2020.
      Han-Lin Chiang, Chiung Mei Chen, Yi-Chun Chen, Chih-Ying Chao, Yih-Ru Wu*, Guey-Jen Lee-Chen*.
    • Association of genetic variants within HLA-DR region with Parkinson's disease in Taiwan.
      Neurobiol Aging. 2020 Mar;87:140.e13-140.e18. doi: 10.1016/j.neurobiolaging.2019.11.002. Epub 2019 Nov 9.
      Kuo-Hsuan Chang, Yih-Ru Wu, Yi-Chun Chen, Hon-Chung Fung, Chiung-Mei Chen*.
    • Ultrasound-responsive neurotrophic factor-loaded microbubble- liposome complex: Preclinical investigation for Parkinson's disease treatment.
      J Control Release. 2020 May 10;321:519-528. doi: 10.1016/j.jconrel.2020.02.044. Epub 2020 Feb 27.
      Chung-Yin Lin, Yu-Chien Lin, Ching-Yun Huang, Shang-Rung Wu, Chiung-Mei Chen*, Hao-Li Liu*.
    • Association of RIT2 and RAB7L1 with Parkinson's disease: a case-control study in a Taiwanese cohort and a meta-analysis in Asian populations.
      Neurobiol Aging. 2020 Mar;87:140.e5-140.e11. doi: 10.1016/j.neurobiolaging.2019.11.001. Epub 2019 Nov 9.
      Tsai-Wei Liu, Yih-Ru Wu, Yi-Chun Chen, Hon Chung Fung, Chiung-Mei Chen*.
    • Neuroprotection of Indole-Derivative Compound NC001-8 by the Regulation of the NRF2 Pathway in Parkinson's Disease Cell Models.
      Oxid Med Cell Longev. 2019 Oct 31;2019:5074367. doi: 10.1155/2019/5074367. eCollection 2019.
      Wei PC, Lee-Chen GJ, Chen CM, Wu YR, Chen YJ, Lin JL, Lo YS, Yao CF, Chang KH*.
    • Pueraria lobata and Daidzein Reduce Cytotoxicity by Enhancing Ubiquitin-Proteasome System Function in SCA3-iPSC-Derived Neurons.
      Oxid Med Cell Longev. 2019 Oct 7;2019:8130481. doi: 10.1155/2019/8130481. eCollection 2019.
      Chen IC, Chang KH, Chen YJ, Chen YC, Lee-Chen GJ, Chen CM*.
    • Association between CSF1 and CSF1R Polymorphisms and Parkinson's Disease in Taiwan.
      J. Clin. Med. 2019, 8(10), 1529; https://doi.org/10.3390/jcm8101529 (registering DOI) - 24 Sep 2019.
      Kuo-Hsuan Chang, Yih-Ru Wu, Yi-Chun Chen, Hsiu-Chuan Wu, Chiung-Mei Chen*.
    • Generation of induced pluripotent stem cells from a young-onset Parkinson'sdisease patient carrying the compound heterozygous PLA2G6 p.D331Y/p.M358IfsX mutations.
      Stem Cell Research. Volume 40, October 2019, 101552. https://doi.org/10.1016/j.scr.2019.101552.
      Chiu CC, Wang HL, Weng YH, Chen RS, Chen CM, Yeh TH, Lu CS, Chen YJ, Liu YC, Huang YZ*, Chang KH*.
    • Focused ultrasound-induced blood brain-barrier opening enhanced vascular permeability for GDNF delivery in Huntington's disease mouse model.
      Brain Stimulation. Volume 12, Issue 5, September–October 2019, Pages 1143-1150. doi: 10.1016/j.brs.2019.04.011.
      Lin CY, Tsai CH, Feng LY, Chai WY, Lin CJ, Huang CY, Wei KC, Yeh CK, Chen CM*, Liu HL*.
    • Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease.
      Nat Commun. 2019 Aug 2;10(1):3473. doi: 10.1038/s41467-019-11441-0.
      Siew JJ, Chen HM, Chen HY, Chen HL, Chen CM, Soong BW, Wu YR, Chang CP, Chan YC, Lin CH, Liu FT, Chern Y*.
    • Modeling Alzheimer's Disease by Induced Pluripotent Stem Cells Carrying APP D678H Mutation.
      Mol Neurobiol. 2019 Jun;56(6):3972-3983. doi: 10.1007/s12035-018-1336-x. Epub 2018 Sep 20.
      Chang KH, Lee-Chen GJ, Huang CC, Lin JL, Chen YJ, Wei PC, Lo YS, Yao CF, Kuo MW, Chen CM*.
    • Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease.
      Neurochemistry International. 2019 May;125:175-186. doi: 10.1016/j.neuint.2019.01.021. Epub 2019 Jan 29.
      Chiu YJ, Hsieh YH, Lin TH, Lee GC, Hsieh-Li HM, Sun YC, Chen CM, Chang KH*, Lee-Chen GJ*.
    • Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease.
      Neurochemistry International. 2019 May;125:175-186. doi: 10.1016/j.neuint.2019.01.021. Epub 2019 Jan 29.
      Chiu YJ, Hsieh YH, Lin TH, Lee GC, Hsieh-Li HM, Sun YC, Chen CM, Chang KH*, Lee-Chen GJ*.
    • Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models.
      Aging (Albany NY). 2019 Feb 13;11(3):986-1007. doi: 10.18632/aging.101804.
      Chen CM, Chen WL, Hung CT, Lin TH, Lee MC, Chen IC, Lin CH, Chao CY, Wu YR, Chang KH, Hsieh-Li HM, Lee-Chen GJ*.
    • Persistence and adherence to rivastigmine in patients with dementia: Results from a noninterventional, retrospective study using the National Health Insurance research database of Taiwan.
      Alzheimers Dement (N Y). 2018 Jul 17;5:46-51. doi: 10.1016/j.trci.2018.06.013. eCollection 2019.
      Chang CJ, Chou TC, Chang CC, Chen TF, Hu CJ, Fuh JL, Wang W, Chen CM, Hsu W, Huang CC*.
    • Indole Compound NC009-1 Augments APOE and TRKA in Alzheimer's Disease Cell and Mouse Models for Neuroprotection and Cognitive Improvement.
      J Alzheimers Dis. 2019;67(2):737-756. doi: 10.3233/JAD-180643.
      Chen YC, Chiu YJ, Lin CH, Hsu WC, Wu JL, Huang CH, Lin CW, Yao CF, Huang HJ, Lo YS, Chen CM, Wu YR, Chang KH*, Lee-Chen GJ*, Mei Hsieh-Li H*.
    • Targeting Ubiquitin Proteasome Pathway with Traditional Chinese Medicine for Treatment of Spinocerebellar Ataxia Type 3.
      Am J Chin Med. 2019;47(1):63-95. doi: 10.1142/S0192415X19500046. Epub 2019 Jan 7.
      Chen IC, Chang CN, Chen WL, Lin TH, Chao CY, Lin CH, Lin HY, Cheng ML, Chiang MC, Lin JY, Wu YR, Lee-Chen GJ, Chen CM*.
    • Polymorphisms of ACMSD-TMEM163, MCCC1, and BCKDK-STX1B Are Not Associated with Parkinson's Disease in Taiwan.
      Parkinsons Dis. 2019 Jan 2;2019:3489638. doi: 10.1155/2019/3489638. eCollection 2019.
      Chang KH, Chen CM, Chen YC, Fung HC, Wu YR*.
    • Novel synthetic chalcone-coumarin hybrid for Aβ aggregation reduction, antioxidation, and neuroprotection.
      CNS Neurosci Ther. 2018 Dec;24(12):1286-1298. doi: 10.1111/cns.13058. Epub 2018 Sep 14.
      Lee SY, Chiu YJ, Yang SM, Chen CM, Huang CC, Lee-Chen GJ*, Lin W*, Chang KH*.
    • Genetic Polymorphisms Associated with Spontaneous Intracerebral Hemorrhage.
      Int J Mol Sci. 2018 Dec 4;19(12). pii: E3879. doi: 10.3390/ijms19123879.
      Chen YC, Chang KH, Chen CM*.
    • Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation.
      Oxid Med Cell Longev. 2018 Oct 28;2018:9595741. doi: 10.1155/2018/9595741. eCollection 2018.
      Chen IC, Lin TH, Hsieh YH, Chao CY, Wu YR, Chang KH, Lee MC, Lee-Chen GJ, Chen CM*.
    • Chinese Herbal Medicine Glycyrrhiza inflataReduces Aβ Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation.
      Am J Chin Med. 2018 Oct 4:1-25. doi: 10.1142/S0192415X18500799. [Epub ahead of print]
      Chiu YJ, Lee CM, Lin TH, Lin HY, Lee SY, Mesri M, Chang KH, Lin JY, Lee-Chen GJ, Chen CM*.
    • Lipophilic antioxidants in neurodegenerative diseases.
      Clin Chim Acta. 2018 Oct;485:79-87. doi: 10.1016/j.cca.2018.06.031. Epub 2018 Jun 22.
      Chang KH, Cheng ML, Chiang MC, Chen CM*.
    • Alternations of Metabolic Profile and Kynurenine Metabolism in the Plasma of Parkinson's Disease.
      Mol Neurobiol. 2018 Aug;55(8):6319-6328. doi: 10.1007/s12035-017-0845-3. Epub 2018 Jan 2.
      Chang KH, Cheng ML, Tang HY, Huang CY, Wu YR, Chen CM*.
    • The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice.
      Neurotoxicology. 2018 Jun 21;67:259-269. doi: 10.1016/j.neuro.2018.06.009. [Epub ahead of print]
      Chen CM, Chen WL, Hung CT, Lin TH, Chao CY, Lin CH, Wu YR, Chang KH, Yao CF, Lee-Chen GJ*, Su MT*, Hsieh-Li HM*.
    • Genetic and functional characters of GRN p.T487I mutation in Taiwanese patients with atypical parkinsonian disorders.
      Parkinsonism Relat Disord. 2018 Jun;51:61-66. doi: 10.1016/j.parkreldis.2018.02.045. Epub 2018 Feb 28.
      Chang KH, Lee GC, Huang CC, Kuo HC, Chen CM, Hsiao YC, Hsu HC, Hsu KJ, Lin CH, Chang CW, Lee-Chen GJ, Wu YR*.
    • DLG2, but not TMEM229B, GPNMB, and ITGA8 polymorphism, is associated with Parkinson's disease in a Taiwanese population.
      Neurobiol Aging. 2018 Apr;64:158.e1-158.e6. doi: 10.1016/j.neurobiolaging.2017.11.016. Epub 2017 Dec 8.
      Wu HC, Chen CM, Chen YC, Fung HC, Chang KH, Wu YR*.
    • Elevated serum levels of endothelin-1 in patients with chronic inflammatory demyelinating polyneuropathy.
      Clinica Chimica Acta.2018 Jan;476:49-53.
      Chang CW, Wu HC, Lyu RK, Lo YS, Chen CM, Ro LS, Chang HS, Huang CC, Liao MF, Wu YR, Kuo HC, Chu CC, Weng YC, Wei PT, Lo AL, Chang KH*.
    • Down-regulation of miR-9* in the peripheral leukocytes of Huntington's disease patients.
      Orphanet J Rare Dis. 2017 Dec 19;12(1):185. doi: 10.1186/s13023-017-0742-x.
      Chang KH, Wu YR, Chen CM*.
    • Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum.
      Int J Mol Sci. 2017 Nov 21;18(11). pii: E2480. doi: 10.3390/ijms18112480.
      Chen CM*, Wu YR, Chang KH.
    • Non-alcoholic Wernicke's encephalopathy with cortical involvement and polyneuropathy following gastrectomy.
      Metab Brain Dis. 2017 Oct;32(5):1649-1657. doi: 10.1007/s11011-017-0055-8. Epub 2017 Jun 28.
      Tsao WC, Ro LS, Chen CM, Chang HC, Kuo HC.
    • Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome.
      Sci Rep. 2017 Aug 15;7(1):8140.
      Tang HY, Chiu DT, Lin JF, Huang CY, Chang KH, Lyu RK, Ro LS, Kuo HC, Cheng ML, Chen CM*.
    • Alterations of plasma concentrations of lipophilic antioxidants are associated with Guillain-Barre syndrome.
      Clin Chim Acta. 2017 May 2;470:75-80.
      Tang HY, Ho HY, Chiu DT, Huang CY, Cheng ML, Chen CM.
    • Patterns of False Memory in Patients with Huntington's Disease.
      Arch Clin Neuropsychol. 2017 Mar 17:1-10.
      Chen IW, Chen CM, Wu YR, Hua MS.
    • Genome-wide association study of Parkinson's disease in East Asians.
      Hum Mol Genet. 2017 Jan 1;26(1):226-232.
      Foo JN, Tan LC, Irwan ID, Au WL, Low HQ, Prakash KM, Ahmad-Annuar A, Bei J, Chan AY, Chen CM, Chen YC, Chung SJ, Deng H, Lim SY, Mok V, Pang H, Pei Z, Peng R, Shang HF, Song K, Tan AH, Wu YR, Aung T, Cheng CY, Chew FT, Chew SH, Chong SA, Ebstein RP, Lee J, Saw SM, Seow A, Subramaniam M, Tai ES, Vithana EN, Wong TY, Heng KK, Meah WY, Khor CC, Liu H, Zhang F, Liu J, Tan EK.
    • Targeting ENT1 and adenosine tone for the treatment of Huntington's disease. Hum Mol Genet.
      Hum Mol Genet. 2017 Feb 1;26(3):467-478.
      Kao YH, Lin MS, Chen CM, Wu YR, Chen HM, Lai HL, Chern Y, Lin CJ.
    • Functional properties of LRRK2 mutations in Taiwanese Parkinson disease.
      J Formos Med Assoc. 2017 Mar;116(3):197-204.
      Chang KH, Chen CM(Co-first author), Lin CH, Chang WT, Jiang PR, Hsiao YC, Wu YR, Lee-Chen GJ.
    • Medicinal herbs Oenanthe javanica (Blume) DC., Casuarina equisetifolia L. and Sorghum bicolor (L.) Moench protect human cells from MPP+ damage via inducing FBXO7 expression.
      Phytomedicine. 2016 Nov 15;23(12):1422-1433.
      Chen CM, Chen IC, Chen YL, Lin TH, Chen WL, Chao CY, Wu YR, Lu YT, Lee CY, Chien HC, Chen TS, Lee-Chen GJ, Lee CM.
    • Increased serum concentrations of transforming growth factor-β1 (TGF-β1) in patients with Guillain-Barre syndrome.
      Clin Chim Acta. 2016 Jul 20;461:8-13.
      Chang KH, Lyu RK, Ro YS, Chen YC, Ro LS, Chang HS, Huang CC, Liao MF, Wu YR, Kuo HC, Chu CC, Chen CM*.
    • Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model.
      J Control Release. 2016 May 26;235:72-81.
      Lin CY, Hsieh HY, Chen CM, Wu SR, Tsai CH, Huang CY, Hua MY, Wei KC, Yeh CK, Liu HL*.
    • Targeting the prodromal stage of spinocerebellar ataxia type 17 mice: G-CSF in the prevention of motor deficits via upregulating chaperone and autophagy levels.
      Brain Res. 2016 May 15;1639:132-48.
      Chang YC, Lin CW, Hsu CM, Lee-Chen GJ, Su MT, Ro LS, Chen CM, Huang HJ, Hsieh-Li HM.
    • Metabolic disturbances in plasma as biomarkers for Huntington's disease.
      J Nutr Biochem. 2016 May;31:38-44.
      Cheng ML, Chang KH, Wu YR, Chen CM*.
    • The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer's disease.
      Drug Des Devel Ther. 2016;10:885–896.
      Chang KH, Chen IC, Lin HY, Chen HC, Lin CH, Lin TH, Weng YT, Chao CY, Wu YR, Lin JY, Lee-Chen GJ, Chen CM*.
    • Impairment of proteasome and anti-oxidative pathways in the induced pluripotent stem cell model for sporadic Parkinson's disease.
      Parkinsonism Relat Disord. 2016 Mar;24:81-88.
      Chang KH, Lee-Chen GJ, Wu YR, Chen YJ, Lin JL, Li M, Chen IC, Lo YS, Wu HC, Chen CM*.
    • Association of GCH1 and MIR4697, but not SIPA1L2 and VPS13C polymorphisms, with Parkinson's disease in Taiwan.
      Neurobiol Aging. 2016 Mar;39:221.e1-5.
      Chen CM, Chen YC, Chiang MC, Fung HC, Chang KH, Lee-Chen GJ, Wu YR.
    • Associations of Matrix Metalloproteinase-9 and Tissue Inhibitory Factor-1 Polymorphisms With Parkinson Disease in Taiwan.
      Medicine (Baltimore). 2016 Feb;95(5):e2672.
      Chen YC, Wu YR, Mesri M, Chen CM*.
    • Novel Lactulose and Melibiose Targeting Autophagy to Reduce PolyQ Aggregation in Cell Models of Spinocerebellar Ataxia 3.
      CNS Neurol Disord Drug Targets. 2016;15(3):351-9.
      Lin CH, Wu YR, Yang JM, Chen WL, Chao CY, Chen IC, Lin TH, Wu YC, Hsu KC, Chen CM, Lee GC, Hsieh-Li HM, Lee CM, Lee-Chen GJ.
    • Polymorphisms in the Promoters of the MMP-2 and TIMP-2 Genes Are Associated with Spontaneous Deep Intracerebral Hemorrhage in the Taiwan Population.
      PLoS One. 2015 Nov 9;10(11):e0142482.
      Chen YC, Ho WM, Lee YS, Chen HW, Chen CM*.
    • STK39, But Not BST1, HLA-DQB1, and SPPL2B Polymorphism, Is Associated With Han-Chinese Parkinson's Disease in Taiwan.
      Medicine (Baltimore). 2015 Oct;94(41):e1690.
      Chang KH, Wu YR, Chen YC, Fung HC, Lee-Chen GJ, Chen CM*.
    • Eukaryotic translation initiation factor 4-γ, 1 gene mutations are rare in Parkinson's disease among Taiwanese.
      J Formos Med Assoc. 2016 Sep;115(9):728-33.
      Weng YC, Chen CM, Chen YC, Fung HC, Chang CW, Chang KH, Wu YR.
    • Elucidating the role of the A2A adenosine receptor in neurodegeneration using neurons derived from Huntington's disease iPSCs.
      Hum Mol Genet. 2015 Nov 1;24(21):6066-79.
      Chiu FL, Lin JT, Chuang CY, Chien T, Chen CM, Chen KH, Hsiao HY, Lin YS, Chern Y, Kuo HC.
    • Protein Kinase Cη Polymorphism and the Susceptibility to Ischemic Stroke in the Taiwan Population.
      Biomed J. 2015 Sep-Oct;38(5):433-8.
      Chen YC, Huang CJ, Chen P, Wu YR, Shie SS, Chen ST, Lee-Chen GJ, Chen CM*.
    • High Protein Diet and Huntington's Disease.
      PLoS One. 2015 May 19;10(5):e0127654.
      Chen CM, Lin YS, Wu YR, Chen P, Tsai FJ, Yang CL, Tsao YT, Chang W, Hsieh IS, Chern Y, Soong BW.
    • The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment.
      Neurotoxicology. 2015 May;48:120-30.
      Lee GC, Lin CH, Tao YC, Yang JM, Hsu KC, Huang YJ, Huang SH, Kung PJ, Chen WL, Wang CM, Wu YR, Chen CM, Lin JY, Hsieh-Li HM, Lee-Chen GJ.
    • Association of MMP-9 Haplotypes and TIMP-1 Polymorphism with Spontaneous Deep Intracerebral Hemorrhage in the Taiwan Population.
      PLoS One. 2015 May 1;10(5):e0125397.
      Ho WM, Chen CM, Lee YS, Chang KH, Chen HW, Chen ST, Chen YC.
    • Biomarkers for neuromyelitis optica.
      Clin Chim Acta. 2015 Feb 2;440C:64-71.
      Chang KH, Ro LS, Lyu RK, Chen CM*.
    • Plasma Inflammatory biomarkers for Huntington's disease patients and mouse model.
      Brain, Behavior, and Immunity, 44 (2015) 121–127.
      Chang KH, Wu YR, Chen YC, and Chen CM*.
    • Role of High Mobility Group Box 1 (HMGB1) in SCA17 Pathogenesis.
      PLoS One. 2014 Dec 30;9(12):e115809.
      Lee LC, Chen CM, Wang PR, Su MT, Lee-Chen GJ, Chang CY.
    • The potential of indole and a synthetic derivative for polyQ aggregationreduction by enhancement of the chaperone and autophagy systems.
      ACS Chem Neurosci. 2014;5(10):1063-74.
      Lin CH, Wu YR, Kung PJ, Chen WL, Lee LC, Lin TH, Chao CY, Chen CM, Chang KH, Janreddy D, Lee-Chen GJ, Yao CF.
    • Deactivation of TBP contributes to SCA17 pathogenesis.
      Hum Mol Genet. 2014;23(25):6878-93.
      Hsu TC, Wang CK, Yang CY, Lee LC, Hsieh-Li HM, Ro LS, Chen CM, Lee-Chen GJ, Su MT.
    • FBXO7 Y52C Polymorphism as a Potential Protective Factor in Parkinson's Disease
      PLoS One. 2014 Jul 16;9(7):e101392.
      Chen CM, Chen IC, Huang YC, Juan HF, Chen YL, Chen YC, Lin CH, Lee LC, Lee CM, Lee-Chen GJ, Lai YJ, Wu YR
    • Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease
      Hum Mol Genet. 2014 Aug 15;23(16):4328-44.
      Hsiao HY, Chiu FL, Chen CM, Wu YR, Chen HM, Chen YC, Kuo HC, Chern Y
    • Aqueous extract of Glycyrrhiza inflata inhibits aggregation through upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3.
      Free Radic Biol Med. 2014 Jun;71:339-50.
      Chen CM, Weng YT, Chen WL, Lin TH, Chao CY, Lin CH, Chen IC, Lee LC, Lin HY, Wu YR, Chen YC, Chang KH, Tang HY, Cheng ML, Lee-Chen GJ, Lin JY.
    • Variant R244H in Na+/Mg2+ exchanger SLC41A1 in Taiwanese Parkinson's disease is associated with loss of Mg2+ efflux function
      Parkinsonism Relat Disord. 2014 Jun;20(6):600-3.
      Lin CH, Wu YR, Chen WL, Wang HC, Lee CM, Lee-Chen GJ, Chen CM*
    • Aqueous extract of Gardenia jasminoides targeting oxidative stress to reduce polyQ aggregation in cell models of spinocerebellar ataxia 3.
      Neuropharmacology. 2014 Jun;81:166-75.
      Chang KH, Chen WL, Wu YR, Lin TH, Wu YC, Chao CY, Lin JY, Lee LC, Chen YC, Lee-Chen GJ, Chen CM*.
    • Downregulation of proteins involved in the endoplasmic reticulum stress response and Nrf2-ARE signaling in lymphoblastoid cells of spinocerebellar ataxia type 17.
      J Neural Transm. 2014;Jun;121(6):601-10.
      Lee LC, Weng YT, Wu YR, Soong BW, Tseng YC, Chen CM*, Lee-Chen GJ.
    • HTRA2 variations in Taiwanese Parkinson's disease.
      J Neural Transm. 2014 May;121(5):491-8.
      Chen CM, Wu CH, Hsieh CH, Lin CH, Chen IC, Chen YC, Lee LC, Lee CM, Tseng YC, Lee-Chen GJ, Wu YR
    • Genetic variants of LRRK2 in Taiwanese Parkinson's disease
      PLoS One. 2013;8(12):e82001.
      Wu YR, Chang KH , Chang WT, Hsiao YC, Hsu HC, Jiang PR, Chen YC, Chao CY, Chang YC, Lee BH, Hu FJ, Chen WL, Lee-Chen GJ, Chen CM*
    • Association between PARK16 and Parkinson's disease in the Han Chinese population: a meta-analysis
      Neurobiol Aging. 2013 Oct;34(10):2442.e5-9.
      Chang KH, Chen CM, Chen YC, Lyu RK, Chang HS, Ro LS, Lee-Chen GJ, Wu YR
    • Internal Ribosome Entry Segment Activity of ATXN8 Opposite Strand RNA.
      PLoS One. 2013 Sep 11;8(9):e73885.
      Chen IC, Lin HY, Hsiao YC, Chen CM, Wu YR, Shiau HC, Shen YF, Huang KS, Su MT, Hsieh-Li HM, Lee-Chen GJ.
    • SLC1A2 Variant Is Associated with Essential Tremor in Taiwanese Population.
      PLoS One. 2013;8(8):e71919.
      Yu SW, Chen CM, Chen YC, Chang CW, Chang HS, Lyu RK, Ro LS, Wu YR.
    • Genetic Variations of GAK in Two Chinese Parkinson's Disease Populations: A Case-Control Study
      PLoS One. 2013 Jun 24;8(6):e67506.
      Tseng WE, Chen CM, Chen YC, Yi Z, Tan EK, Wu YR
    • A comparison of benign and inflammatory manifestations of Tolosa-Hunt syndrome
      Cephalalgia. 2013 Jul;33(10):842-52.
      Hung CH, Chang KH, Wu YM, Chen YL, Lyu RK, Chang HS, Wu YR, Chen CM, Huang CC, Chu CC, Liao MF, Wai YY, Hsu SP, Ro LS
    • Identification of a novel risk variant in the FUS gene in essential tremor
      Neurology. 2013 Aug 6;81(6):541-4.
      Wu YR, Foo JN, Tan LC, Chen CM, Prakash KM, Chen YC, Bei JX, Au WL, Chang CW, Wong TY, Liu JJ, Zhao Y, Tan EK
    • Association between GRN rs5848 polymorphism and Parkinson's disease in Taiwanese population
      PLoS One. 2013;8(1):e54448.
      Chang KH, Chen CM, Chen YC, Hsiao YC, Huang CC, Kuo HC, Hsu HC, Lee-Chen GJ, Wu YR
    • Mutations of proline-rich transmembrane protein-2 and paroxysmal kinesigenic dyskinesia in Taiwan
      Mov Disord. 2013 Sep;28(10):1459-60.
      Chen YC, Lee YS, Shih CC, Wu T, Chen CM*
    • Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3
      Evid Based Complement Alternat Med. 2013;2013:471659. doi: 10.1155/2013/471659.
      Chang KH, Chen WL, Lee LC, Lin CH, Kung PJ, Lin TH, Wu YC, Wu YR, Chen YC, Lee-Chen GJ, and Chen CM*
    • Distinct features between longitudinally extensive transverse myelitis presenting with and without anti-aquaporin 4 antibodies
      Mult Scler. 2013 Mar;19(3):299-307.
      Chang KH, Lyu RK, Chen CM, Wu YR, Chang HS, Huang CC, Kuo HC, Chu CC, Hsu WC, Ro LS
    • Analyses of haptoglobin level in the cerebrospinal fluid and serum of patients with neuromyelitis optica and multiple sclerosis
      Clin Chim Acta. 2013 Feb 18;417:26-30
      Chang KH, Tseng MY, Ro LS, Lyu RK, Tai YH, Chang HS, Wu YR, Huang CC, Hsu WC, Kuo HC, Chu CC, Chen CM*
    • Genetic analysis of NFE2L2 promoter variation in Taiwanese Parkinson's disease
      Parkinsonism Relat Disord. 2013 Feb;19(2):247-50.
      Chen YC, Wu YR, Wu YC, Lee-Chen GJ, Chen CM*
    • ATXN8 -62 G/A promoter polymorphism and risk of Taiwanese Parkinson's disease
      Eur J Neurol. 2012 Nov;19(11):1462-9.
      Chen IC, Wu YR, Yang SJ, Kao SH, Chen YC, Chang KH, Lee CM, Lee-Chen GJ, Chen CM*
    • Downregulation of Genes Involved in Metabolism and Oxidative Stress in the Peripheral Leukocytes of Huntington's Disease Patients
      PLoS ONE 2012;7(9): e46492.
      Chang K-H, Chen Y-C, Wu Y-R, Lee W-F, Chen C-M*
    • Protein kinase Cη polymorphism and the susceptibilities to intracerebral hemorrhage in the Taiwan population
      Neurosci Lett. 2012 Oct 24;528(2):170-3.
      Chen YC, Chen P, Wu YR, Shie SS, Chen ST, Lee-Chen GJ, Chen CM*
    • Distinct features between longitudinally extensive transverse myelitis presenting with and without anti-Aquaporin 4 antibodies. Mult Scler
      2012 Jul 24. [Epub ahead of print]
      Chang KH, Lyu RK, Chen CM, Wu YR, Chang HS, Huang CC, Kuo HC, Chu CC, Hsu WC, Ro LS
    • LRRK2 A419V Is Not Associated with Parkinson's Disease in Different Chinese Populations
      PLoS ONE. 2012;7(7):e36123.
      Wu YR, Tan LC, Fu X, Chen CM, Au WL, Chen L, Chen YC, Prakash KM, Zheng Y, Lee-Chen GJ, Zhao Y, Zeng JS, Tan EK, Pei Z
    • Role of the CCAAT-Binding Protein NFY in SCA17 Pathogenesis
      PLoS One. 2012;7(4):e35302.
      Lee LC, Chen CM(co-first author), Wang PR, Wang HC, Hsieh HH, Su MT, Li-Hsieh HM, Wu CH, Lee GC, Lee-Chen Guey-Jen Lin JY
    • Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease
      Parkinsonism Relat Disord. 2012 May;18(4):391-3.
      Chiang HL, Lee-Chen GJ, Chen CM, Chen YC, Lee CM, Liao MH, Wu YR
    • LINGO-2 polymorphism and the risk of Parkinson's disease in Taiwan
      Parkinsonism Relat Disord. 2012 Jun;18(5):609-11.
      Su FC, Chen CM, Chen YC, Wu YR
    • Identification of Gene Networks and Pathways Associated with Guillain-Barre Syndrome.
      PLoS ONE. 2012;7(1): e29506.
      Chang KH, Chuang TJ, Lyu RK, Ro LS, Wu YR, Chang HS, Huang CC, Kuo HC, Hsu WC, Chu CC , Chen CM*.
    • Distinct features between longitudinally extensive transverse myelitis presenting with and without anti-Aquaporin 4 antibodies
      Mult Scler. 2012 Jul 31. Mar;19(3):299-307.
      Chang KH, Lyu RK, Chen CM, Wu YR, Chang HS, Huang CC, Kuo HC, Chu CC, Hsu WC, Ro LS