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醫療團隊

專業的醫護人員，提供最佳的醫療服務

醫師介紹

  •

陳妙芬醫師

食道癌、乳癌、泌尿道癌、肺癌之光子與質子治療、立體定位放射治療、輻射生物基礎及轉譯研究
  • 國語,英語,閩南語
  • 教授
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醫師資歷
  • 現職
    • 長庚醫院學術組教授級主治醫師
    • 長庚大學部定教授
  • 學歷
    • 長庚大學臨床醫學研究所博士
    • 台北醫學院醫學系
  • 經歷
    • 2014~ 　　長庚大學部定教授
    • 2013~ 　　長庚醫院放射腫瘤科教授級主治醫師
    • 2011~2014 長庚大學專任副教授
    • 2010~2013 長庚醫院放射腫瘤科副教授級主治醫師
    • 2008~2011 長庚大學專任助理教授
    • 2007~2010 長庚醫院放射腫瘤科助理教授級主治醫師
  • 學會與認證
    • 台灣放射腫瘤學會
  • 論文及期刊發表
    • Role of vitamin D3 in tumor aggressiveness and radiation response for hepatocellular carcinoma.
      Mol Carcinog . 2022 Aug;61(8):787-796
      林口長庚紀念醫院 放射腫瘤科
    • Prospective Evaluation of Taste Function in Patients With Head and Neck Cancer Receiving Intensity-Modulated Radiotherapy.
      JAMA Otolaryngol Head and Neck Surgery. 2022 Jul; 148(7):604-611.
      林口長庚紀念醫院 放射腫瘤科
    • Effect of 1α,25-Dihydroxyvitamin D3 on the Radiation Response in Prostate Cancer: Association With IL-6 Signaling.
      Front Oncol. 2021 May 24;11:619365. (* Corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Role of Nutritional Status in the Treatment Outcome for Esophageal Squamous Cell Carcinoma.
      Nutrients. 2021 Aug 28;13(9):2997.
      林口長庚紀念醫院 放射腫瘤科
    • Intracavernous Injection of Autologous Platelet-Rich Plasma Ameliorates Hyperlipidemia-Associated Erectile Dysfunction in a Rat Model.
      Sex Med. 2021 Apr;9(2):100317.
      林口長庚紀念醫院 放射腫瘤科
    • Risk of major adverse cardiovascular events among second-line hormonal therapy for metastatic castration-resistant prostate cancer: A real-world evidence study.
      Prostate. 2021 Feb;81(3):194-201. doi: 10.1002/pros.24096
      林口長庚紀念醫院 放射腫瘤科
    • Survival of Patients with Lung Cancer in the Setting of Liver Cirrhosis: A Multicenter Propensity Score Matching Study.
      Cancer Manag Res. 2021 Jun 1;13:4373-4381. (* Corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Survival-Weighted Health Profiles in Nasopharyngeal Cancer Patients.
      Front Oncol. 2021 Mar 15;11:635667.
      林口長庚紀念醫院 放射腫瘤科
    • A Retrospective Analysis of Dose Distribution and Toxicity in Patients with Left Breast Cancer Treated with Adjuvant Intensity-Modulated Radiotherapy: Comparison with Three-Dimensional Conformal Radiotherapy.
      Cancer Manag Res. 2020;12:9173-9182. (* Corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Prognostic Significance of Neoadjuvant Rectal Scores in Preoperative Short-Course Radiotherapy and Long-Course Concurrent Chemoradiotherapy for Patients with Locally Advanced Rectal Cancer.
      Ann Surg Oncol. 2020 Oct;27(11):4309-4318 (* Co-Corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Porphyromonas gingivalis promotes tumor progression in esophageal squamous cell carcinoma.
      Cell Oncol (Dordr). 2021 Apr;44(2):373-384. doi: 10.1007/s13402-020-00573-x.
      林口長庚紀念醫院 放射腫瘤科
    • The Predictive Role of Prostate-Specific Antigen Changes Following Transurethral Resection of the Prostate for Patients with Localized Prostate Cancer.
      Cancers (Basel). 2020 Dec 29;13(1):74.
      林口長庚紀念醫院 放射腫瘤科
    • The Significance of Neutrophil-to-Lymphocyte Ratio and Combined Chemoradiotherapy in Patients Undergoing Bladder Preservation Therapy for Muscle-Invasive Bladder Cancer.
      Cancer Manag Res. 2020 Dec 22;12:13125-13135.
      林口長庚紀念醫院 放射腫瘤科
    • Prognostic Significance of Neoadjuvant Rectal Scores in Preoperative Short-Course Radiotherapy and Long-Course Concurrent Chemoradiotherapy for Patients with Locally Advanced Rectal Cancer.
      Ann Surg Oncol. 2020 Oct;27(11):4309-4318
      林口長庚紀念醫院 放射腫瘤科
    • Effect of Tumor Burden on Tumor Aggressiveness and Immune Modulation in Prostate Cancer: Association with IL-6 Signaling.
      Cancers (Basel). 2019 Jul 16;11(7). pii: E992. (* Corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Long-Term Taste Impairment after Intensity-Modulated Radiotherapy to Treat Head-and-Neck Cancer: Correlations with Glossectomy and the Mean Radiation Dose to the Oral Cavity.
      Chem Senses. 2019 May 29;44(5):319-326. (* Corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • The prognosis of head and neck squamous cell carcinoma related to immunosuppressive tumor microenvironment regulated by IL-6 signaling.
      Oral Oncol. 2019 Apr;91:47-55. (* Corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Lung cancer outcome in the setting of chronic kidney disease: Does the glomerular filtration estimation formula matter?
      Thorac Cancer. 2019 Feb;10(2):268-276
      林口長庚紀念醫院 放射腫瘤科
    • The Response of Prostate Cancer to Androgen Deprivation and Irradiation Due to Immune Modulation.
      Cancers (Basel). 2018 Dec 26;11(1). pii: E20. (* Corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • The Predictive Value of Pretreatment Neutrophil-To-Lymphocyte Ratio in Esophageal Squamous Cell Carcinoma.
      Ann Surg Oncol. 2019 Jan;26(1):190-199
      林口長庚紀念醫院 放射腫瘤科
    • Predictive Value of the Pretreatment Neutrophil-to-Lymphocyte Ratio in Head and Neck Squamous Cell Carcinoma.
      J Clin Med. 2018 Sep 20;7(10). pii: E294.
      林口長庚紀念醫院 放射腫瘤科
    • Predictive Value of CD44 in Muscle-Invasive Bladder Cancer and Its Relationship with IL-6 Signaling.
      Ann Surg Oncol. 2018; 25(12):3518-3526. (* Corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Cell Subpopulations Overexpressing p75NTR Have Tumor-initiating Properties in the C6 Glioma Cell Line.
      Anticancer Res. 2018 Sep;38(9):5183-5192.
      林口長庚紀念醫院 放射腫瘤科
    • Epigenetic therapy regulates the expression of ALDH1 and immunologic response: Relevance to the prognosis of oral cancer.
      Oral Oncol. 2017; 73:88-96. (* Corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Cystectomy for bladder cancer in elderly patients is not associated with increased 30- and 90-day mortality or readmission, length of stay, and cost: propensity score matching using a population database.
      Cancer Manag Res. 2018 May 31;10:1413-1418.
      林口長庚紀念醫院 放射腫瘤科
    • Role of ALDH1 in the prognosis of esophageal cancer and its relationship with tumor microenvironment.
      Mol Carcinog. 2018 Jan; 57(1):78-88 (* Corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Survival benefit of surgery to patients with esophageal squamous cell carcinoma.
      Sci Rep. 2017 Apr 6;7:46139
      林口長庚紀念醫院 放射腫瘤科
    • Impact of CD44 expression on radiation response for bladder cancer.
      J Cancer. 2017 Apr 9;8(7):1137-1144 (* Corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Inflammation-induced myeloid-derived suppressor cells associated with squamous cell carcinoma of the head and neck.
      Head Neck. 2017;39(2):347-355. (* Corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Is chronic kidney disease an adverse factor in lung cancer clinical outcome? A propensity score matching study.
      Thorac Cancer. 2017 Mar;8(2):106-113.
      林口長庚紀念醫院 放射腫瘤科
    • To Operate or Not: Prediction of 3-Month Postoperative Mortality in Geriatric Cancer Patients.
      J Cancer. 2016 Jan 1;7(1):14-21.
      林口長庚紀念醫院 放射腫瘤科
    • he role of PD-L1 in the radiation response and prognosis for esophageal squamous cell carcinoma related to IL-6 and T-cell immunosuppression.
      Oncotarget. 2016 Feb 16;7(7):7913-24.
      林口長庚紀念醫院 放射腫瘤科
    • The role of PD-L1 in the radiation response and clinical outcome for bladder cancer.
      Sci Rep. 2016 Jan 25;6:19740. (* Corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Identification of High-Risk Subgroups of Patients With Oral Cavity Cancer in Need of Postoperative Adjuvant Radiotherapy or Chemo-Radiotherapy.
      Medicine (Baltimore). 2016 May;95(22):e3770. (* Corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • 1α,25- Dihydroxyvitamin D3 Inhibits Esophageal Squamous Cell Carcinoma Progression by Reducing IL6 Signaling.
      Mol Cancer Ther. 2015 Jun;14(6):1365-75. (* Corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Androgen deprivation increases the risk of fracture in prostate cancer patients: a population-based study in Chinese patients.
      Osteoporos Int. 2015 Sep;26(9):2281-90. (* Co-corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • The Efficacy of Postoperative Adjuvant Chemotherapy for Patients with pT3N0M0 Upper Tract Urothelial Carcinoma.
      J Urol. 2015 Aug;194(2):323-9
      林口長庚紀念醫院 放射腫瘤科
    • A simple risk stratification model that predicts 1-year postoperative mortality rate in patients with solid-organ cancer.
      Cancer Med. 2015 Aug 26.
      林口長庚紀念醫院 放射腫瘤科
    • TGF Beta1 Expression Correlates with Survival and Tumor Aggressiveness of Prostate Cancer.
      Ann Surg Oncol. 2015 Ann Surg Oncol. 2015 Dec;22 Suppl 3:1587-93. (* Corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • A simple risk stratification model that predicts 1-year postoperative mortality rate in patients with solid-organ cancer.
      Cancer Med. 2015 Nov;4(11):1687-96
      林口長庚紀念醫院 放射腫瘤科
    • Significance of DNMT3b in oral cancer.
      PLoS One. 2014 Mar 13;9(3):e89956. ( *co-first author)
      林口長庚紀念醫院 放射腫瘤科
    • Thrombomodulin expression regulates tumorigenesis in bladder cancer.
      BMC Cancer. 2014 May 28;14(1):375. (* corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • stimation of life expectancy and quality-adjusted life expectancy in non-metastatic nasopharyngeal cancer patients treated by intensity-modulated radiotherapy with or without chemotherapy.
      Oral Oncol. 2014 Jul;50(7):646-50
      林口長庚紀念醫院 放射腫瘤科
    • TGF-β1 mediates the radiation response of prostate cancer.
      J Mol Med (Berl). 2014 Sep 18. (* Corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • IL-6-stimulated CD11b+ CD14+ HLA-DR- myeloid-derived suppressor cells, are associated with progression and poor prognosis in squamous cell carcinoma of the esophagus.
      Oncotarget. 2014 Sep 30;5(18):8716-28 (Corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Clinical characteristics and treatment outcome in a Taiwanese population of patients with Epstein-Barr virus-positive diffuse large B-cell lymphoma.
      Jpn J Clin Oncol. 2014 Dec;44(12):1164-71.
      林口長庚紀念醫院 放射腫瘤科
    • The role of IL-6 in the radiation response of prostate cancer.
      Radiat Oncol. 2013;8:159.
      林口長庚紀念醫院 放射腫瘤科
    • Outcome of patients with esophageal cancer: a nationwide analysis.
      Ann Surg Oncol. 2013;20(9):3023-30.
      林口長庚紀念醫院 放射腫瘤科
    • IL-6 expression regulates tumorigenicity and correlates with prognosis in bladder cancer.
      PLoS One. 2013;8(4):e61901
      林口長庚紀念醫院 放射腫瘤科
    • Scintigraphic assessment of salivary function after intensity-modulated radiotherapy for head and neck cancer: Correlations with parotid dose and quality of life.
      Oral Oncol. 2013;49(1):42-8. (* corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Role of Interleukin-6 in the Radiation Response of Liver Tumors.
      Int J Radiat Oncol Biol Phys. 2012;84(5):e621-30 (* corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Detection of Mucosal Recurrent Nasopharyngeal Carcinomas after Radiotherapy with Narrow-Band Imaging Endoscopy.
      Int J Radiat Oncol Biol Phys. 2012;83(4):1213-9.
      林口長庚紀念醫院 放射腫瘤科
    • Role of DNA methyltransferase 3b in esophageal squamous cell carcinoma.
      Cancer, 2012;118(16):4074-89
      林口長庚紀念醫院 放射腫瘤科
    • Significance of IL-6 in the transition of hormone-resistance prostate cancer and the induction of myeloid derived suppressor cells .
      J Mol Med. 2012,;90(11):1343-55 (* corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Comparison of treatment results between surgery alone, preoperative short-course radiotherapy, or long-course concurrent chemoradiotherapy in locally advanced rectal cancer.
      Int J Clin Oncol. 2011; in press(* corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Significance of the TGF-beta1-IL-6 axis in oral cancer.
      Clin Sci. 2012; 122(10):459-72
      林口長庚紀念醫院 放射腫瘤科
    • Role of DNA methyltransferase 3b in esophageal squamous cell carcinoma.
      Cancer, 2012;118(16):4074-89
      林口長庚紀念醫院 放射腫瘤科
    • Significance of IL-6 in the transition of hormone-resistance prostate cancer and the induction of myeloid derived suppressor cells .
      J Mol Med. 2012,;90(11):1343-55 (* corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Expression and function role of DNA methyltransferase 1 in human bladder cancer.
      Cancer, 2011;117(22):5221-33. (* corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • CK2 inhibitors enhance the radiosensitivity of human non-small cell lung cancer cells through inhibition of stat3 activation.
      Cancer Biother Radiopharm. 2011;26(3):381-8.
      林口長庚紀念醫院 放射腫瘤科
    • Incidence and Patterns of Second Primary Malignancies Following Oral Cavity Cancers in a Prevalent Area of Betel-nut Chewing: A Population-based Cohort of 26 166 Patients in Taiwan.
      Jpn J Clin Oncol. 2011;41(12):1336-43
      林口長庚紀念醫院 放射腫瘤科
    • Significance of IL-6 signaling in pharyngeal cancer in its resistance to irradiation and the EGFR inhibitor.
      Int J Radiat Oncol Biol Phys, 2010;76(4):1214-24 (* corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • The role of peroxiredoxin I in rectal cancer and related to p53 status.
      Int J Radiat Oncol Biol Phys, 2010;78(3):868-78
      林口長庚紀念醫院 放射腫瘤科
    • Predictive factors of radiation-induced skin toxicity in breast cancer patients.
      BMC Cancer. 2010 Sep 23;10:508.
      林口長庚紀念醫院 放射腫瘤科
    • Role of DNA methyltransferase 1 in hormone-resistant prostate cancer .
      J Mol Med. 2010; 88(9):953-62
      林口長庚紀念醫院 放射腫瘤科
    • Inhibition of corneal neovascularization with plasmid pigment epithelium-derived factor (p-PEDF) delivered by synthetic amphiphile INTeraction-18 (SAINT-18) vector in an experimental model of rat corneal angiogenesis.
      Exp Eye Res. 2009
      林口長庚紀念醫院 放射腫瘤科
    • Adenovirus-mediated transfer of siRNA against survivin enhances the radiosensitivity of human non-small cell lung cancer cells.
      Cancer Gene Therapy, 2009
      林口長庚紀念醫院 放射腫瘤科
    • Comparison between pre-operative short course radiotherapy and long course chemoradiotherapy in patients with locally advanced rectal cancers.
      Therapeutic Radiology and Oncology; 2009,16: 165-177. (* corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Androgen deprivation modulates the inflammatory response induced by irradiation.
      BMC Cancer. 2009, 9:92 (* corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • The predictive role of E2-EPF ubiquitin carrier protein in esophageal squamous cell carcinoma.
      J Mol Med. 2009, 87: 307-320
      林口長庚紀念醫院 放射腫瘤科
    • Significance of nuclear accumulation of Foxo3a in esophageal squamous cell carcinoma.
      Int J Radiat Oncol Biol Phys, 2008, 71:1220-1229(* corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Adjuvant concurrent chemoradiotherapy with intensity-modulated pelvic radiotherapy after surgery for high-risk, early stage cervical cancer patients.
      Cancer J, 2008,14(3):200-206
      林口長庚紀念醫院 放射腫瘤科
    • Clinical outcome in post-hysterectomy cervical cancer patients treated with concurrent cisplatin and intensity-modulated pelvic radiotherapy: comparison with conventional radiotherapy.
      Int J Radiat Oncol Biol Phys, 2007; 67: 1438-1444
      林口長庚紀念醫院 放射腫瘤科
    • The radiation response for hormone- resistant prostate cancer induced by long- term hormone therapy.
      Endocrine-Related Cancer, 2007;14:633-645 (* corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Predictive role of nuclear factor-κB activity in gastric cancer: A promising adjuvant approach with caffeic acid phenethyl ester.
      J of Clinical Gastroenterlogy,2007; 41:894-900
      林口長庚紀念醫院 放射腫瘤科
    • Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression.
      Int J Radiat Oncol Biol Phys 2006; 64: 581-91
      林口長庚紀念醫院 放射腫瘤科
    • The sensitivity of human mesenchymal stem cells to ionizing radiation.
      Int J Radiat Oncol Biol Phys 2006; 66: 244-253
      林口長庚紀念醫院 放射腫瘤科
    • P53 status is a major determinant of the effects of decreasing peroxiredoxin I expression on tumor growth and response of lung cancer cells to treatment.
      Int J Radiat Oncol Biol Phys, 2006; 66: 1461-1472
      林口長庚紀念醫院 放射腫瘤科
    • Differential effects of caffeic acid phenethyl ester for normal lung and lung cancer treated with irradiation: in vitro and in vivo study.
      BMC Cancer, 2005;5:158
      林口長庚紀念醫院 放射腫瘤科
    • Prediction of poor survival by cyclooxygenase-2 in patients with T4 nasopharyngeal cancer treated by radiation therapy: clinical and in vitro studies.
      Head Neck 2005; 27:503-512. (* corresponding author)
      林口長庚紀念醫院 放射腫瘤科
    • Cell killing and radiosensitization by caffeic acid phenethyl ester (CAPE) in lung cancer cells.
      J of Radiat Research, 45, 253-260, 2004
      林口長庚紀念醫院 放射腫瘤科
    • The role of radiotherapy in the treatment of early stage glottic cancer.
      Annals of otology, rhinology & laryngology, 2003,10: 904-911
      林口長庚紀念醫院 放射腫瘤科