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醫療團隊

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醫師介紹

  •

田祐霖醫師

兒童腎臟學、腎臟生理學、自由基醫學、高血壓、胎幼兒期防治成人疾病
  • 國語,英語,閩南語
  • 教授
醫師網路掛號
直接點選進入醫師網路掛號畫面
醫師資歷
  • 現職
    • 高雄長庚紀念醫院兒童內科部主任
    • 長庚大學醫學系教授
    • 高雄長庚紀念醫院兒童腎臟科主任
    • 高雄長庚醫院學術組教授
  • 學歷
    • 中國醫藥大學醫學系
    • 長庚大學臨床醫學研究所碩士
    • 美國佛羅里達大學生理學博士
  • 經歷
    • 高雄長庚紀念醫院醫學研究部主任
    • 高雄長庚紀念醫院兒童內科部副部主任
    • 高雄長庚紀念醫院兒童腎臟科主治醫師
  • 學會與認證
    • 台灣兒科醫學會理事
    • 台灣兒童腎臟醫學會理事
    • 台灣胎幼兒期防治成人疾病學會理事
    • 台灣腎臟醫學會
    • 中華民國醫用超音波學會
  • 論文及期刊發表
    • Chondroitin Sulfate Ameliorates Hypertension in Male Offspring Rat Born to Mothers Fed an Adenine Diet.
      Antioxidants 2024, 13, 944.
      Tain YL, Hsu CN.
    • Resveratrol Propionate Ester Supplement Exerts Antihypertensive Effect in Juvenile Rats Exposed to an Adenine Diet via Gut Microbiota Modulation.
      Nutrients. 2024 Jul 4;16(13):2131.
      Tain YL, Chang CI, Hou CY, Chang-Chien GP, Lin SF, Hsu CN.
    • Amino Acids during Pregnancy and Offspring Cardiovascular-Kidney-Metabolic Health.
      Nutrients. 2024 Apr 24;16(9):1263.
      Tain YL, Hsu CN.
    • Guideline-Adherent Hypertension in Children and Adolescents: A Multi-Institutional Database Analysis from Taiwan.
      J. Clin. Med. 2023, 12, 4367.
      Chien SJ, Li LC, Kuo HC, Tain YL, Hsu CN.
    • Cardiovascular Diseases Morbidity and Mortality among Children Adolescents and Young Adults with Dialysis Therapy.
      Front. Public Health 2023; 11:1142414.
      Li LC, Tain YL, Kuo HC and Hsu CN.
    • A Higher Abundance of Actinomyces spp. In the Gut Is Associated with Spontaneous Preterm Birth.
      Microorganisms. 2023 Apr 29;11(5):1171.
      Yu HR, Tsai CC, Chan JYH, Lee WC, Wu KLH, Tain YL, Hsu TY, Cheng HH, Huang HC, Huang CH, Pan WH, Yeh YT. A Higher Abundance of Actinomyces spp. In the Gut Is Associated with Spontaneous Preterm Birth.
    • Evaluation of the Feasibility of In Vitro Metabolic Interruption of Trimethylamine with Resveratrol Butyrate Esters and Its Purified Monomers.
      Molecules. 2024 Jan 16;29(2):429.
      Huang PH, Chen DQ, Chen YW, Shih MK, Lee BH, Tain YL, Hsieh CW, Hou CY.
    • Cardiovascular risk of dietary trimethylamine oxide precursors and the therapeutic potential of resveratrol and its derivatives.
      FEBS Open Bio. 14(3): 355-528, 2024.
      Hou CY, Chen YW, Hazeena SH, Tain YL, Hsieh CW, Chen DQ, Liu RY, Shih MK.
    • Butyrate reduction and HDAC4 increase underlie maternal high fructose-induced metabolic dysfunction in hippocampal astrocytes in female rats.
      J Nutr Biochem. 2024 Jan 8;126:109571.
      Wu KLH, Liu WC, Wu CW, Fu MH, Huang HM, Tain YL, Liang CK, Hung CY, Chen IC, Hung PL, Lin YJ, Hirase H.
    • Association of Perinatal Cardiovascular Features with Angiotensin System Expressions in Maternal Preeclampsia.
      Int J Mol Sci. 2024 Jul 6;25(13):7426.
      Lin IC, Wu KLH, Cheng HH, Tsai CC, Yu HR, Hsu TY, Tain YL, Huang LT, Lai YJ.
    • Carbohydrate-Mediated Pregnancy Gut Microbiota and Neonatal Low Birth Weight.
      Nutrients. 2024 Apr 28;16(9):1326.
      Yu HR, Yeh YT, Tzeng HT, Dai HY, Lee WC, Wu KLH, Chan JYH, Tain YL, Hsu CN.
    • Gestational Exposure to Maternal Systemic Glucocorticoids and Childhood Risk of CKD.
      Am J Kidney Dis. 2024 Mar 11:S0272-6386(24)00669-3. doi: 10.1053/j.ajkd.2024.01.523.
      Tain YL, Li LC, Kuo HC, Hsu CN.
    • Interplay between maternal nutrition and epigenetic programming on offspring hypertension.
      J Nutr Biochem. 127:109604, 2024.
      Tain YL, Hsu CN.
    • The Impact of the Aryl Hydrocarbon Receptor on Antenatal Chemical Exposure-Induced Cardiovascular–Kidney–Metabolic Programming.
      Int. J. Mol. Sci. 2024, 25, 4599
      Tain YL, Hsu CN.
    • Melatonin Use during Pregnancy and Lactation Complicated by Oxidative Stress: Focus on Offspring’s Cardiovascular–Kidney– Metabolic Health in Animal Models.
      Antioxidants 2024, 13, 226.
      Tain YL, Hsu CN.
    • The Renin–Angiotensin System and Cardiovascular–Kidney–Metabolic Syndrome: Focus on Early-Life Programming.
      Int. J. Mol. Sci. 2024, 25, 3298.
      Tain YL, Hsu CN.
    • Cardiovascular risk of dietary trimethylamine oxide precursors and the therapeutic potential of resveratrol and its derivatives.
      FEBS Open Bio. 14(3): 355-528, 2024.
      Hou CY, Chen YW, Hazeena SH, Tain YL, Hsieh CW, Chen DQ, Liu RY, Shih MK.
    • Evaluation of the Feasibility of In Vitro Metabolic Interruption of Trimethylamine with Resveratrol Butyrate Esters and Its Purified Monomers.
      Molecules. 2024 Jan 16;29(2):429.
      Huang PH, Chen DQ, Chen YW, Shih MK, Lee BH, Tain YL, Hsieh CW, Hou CY.
    • Perinatal Use of Citrulline Rescues Hypertension in Adult Male Offspring Born to Pregnant Uremic Rats.
      Int. J. Mol. Sci. 2024, 25, 1612.
      Tain YL, Hou CY, Chang-Chien GP, Lin S, Hsu CN.
    • Nutritional Approaches Targeting Gut Microbiota in Oxidative-Stress-Associated Metabolic Syndrome: Focus on Early Life Programming.
      Nutrients 2024, 16, 683.
      Tain YL, Hsu CN.
    • Guideline-Adherent Hypertension in Children and Adolescents: A Multi-Institutional Database Analysis from Taiwan.
      J. Clin. Med. 2023, 12, 4367.
      Chien SJ, Li LC, Kuo HC, Tain YL, Hsu CN.
    • Cardiovascular Diseases Morbidity and Mortality among Children Adolescents and Young Adults with Dialysis Therapy.
      Front. Public Health 2023; 11:1142414.
      Li LC, Tain YL, Kuo HC and Hsu CN.
    • A Higher Abundance of Actinomyces spp. In the Gut Is Associated with Spontaneous Preterm Birth.
      Microorganisms. 2023 Apr 29;11(5):1171.
      Yu HR, Tsai CC, Chan JYH, Lee WC, Wu KLH, Tain YL, Hsu TY, Cheng HH, Huang HC, Huang CH, Pan WH, Yeh YT.
    • Protection by Means of Perinatal Oral Sodium Thiosulfate Administration against Offspring Hypertension in a Rat Model of Maternal Chronic Kidney Disease.
      Antioxidants 2023, 12, 1344.
      Hsu CN, Hou CY, Chang-Chien GP, Lin S, Tain YL.
    • Maternal High-Fat Diet Controls Offspring Kidney Health and Disease.
      Nutrients. 2023 Jun 9;15(12):2698.
      Liu HY, Lee CH, Hsu CN, Tain YL.
    • Sulfur-Containing Amino Acids, Hydrogen Sul?de, and Sulfur Compounds on Kidney Health and Disease.
      Metabolites 2023, 13, 688.
      Chen CJ, Chen MC, Hsu, CN, Tain YL.
    • The Impact of Nutrient Intake and Metabolic Wastes During Pregnancy on Offspring Hypertension: Challenges and Future Opportunities.
      Metabolites 2023, 13, 418.
      Tain YL, Hsu CN.
    • Anti-Hypertensive Property of an NO Nanoparticle in an Adenine-Induced Chronic Kidney Disease Young Rat Model.
      Antioxidants (Basel). 2023;12:513.
      Tain YL, Yang HW, Hou CY, Chang-Chien GP, Lin S, Hsu CN.
    • Role of the Gut Microbiota in Children with Kidney Disease.
      Children 2023, 10, 269.
      Tain YL, Hsu CN.
    • Resveratrol Butyrate Ester Supplementation Blunts the Development of Offspring Hypertension in a Maternal Di-2-ethylhexyl Phthalate Exposure Rat Model.
      Nutrients. 2023, 15:697.
      Tain YL, Hou CY, Chang-Chien GP, Lin S, Hsu CN.
    • Perinatal Garlic Oil Supplementation Averts Rat Offspring Hypertension Programmed by Maternal Chronic Kidney Disease.
      Nutrients. 2022 Nov 2;14(21):4624.
      Tain YL, Hou CY, Chang-Chien GP, Lin S, Hsu CN.
    • Perinatal Oxidative Stress and Kidney Health: Bridging the Gap between Animal Models and Clinical Reality.
      Antioxidants (Basel). 2022 Dec 21;12(1):13.
      Tain YL, Hsu CN.
    • Iodomethylcholine Inhibits Trimethylamine-N-Oxide Production and Averts Maternal Chronic Kidney Disease-Programmed Offspring Hypertension.
      Int J Mol Sci. 2023 Jan 9;24(2):1284.
      Tain YL, Chang-Chien GP, Lin S, Hou CY, Hsu CN.
    • Cardiovascular Risks of Hypertension: Lessons from Children with Chronic Kidney Disease.
      Children 2022, 9, 1650.
      Tain YL, Hsu CN.
    • Metabolic Syndrome Programming and Reprogramming: Mechanistic Aspects of Oxidative Stress.
      Antioxidants 2022, 11, 2108.
      Tain YL, Hsu CN.
    • Lipopolysaccharide-induced Autophagy Increases SOX2-positive Astrocytes While Decreasing Neuronal Differentiation in the Adult Hippocampus.
      Exp Neurobiol. 2022 Oct 31;31(5):307-323.
      Liu WC, Wu CW, Fu MH, Tain YL, Liang CK, Chen IC, Hung CY, Lee YC, Wu KLH.
    • Kidney Function Trajectory within Six Months after Acute Kidney Injury Inpatient Care and Subsequent Adverse Kidney Outcomes: A Retrospective Cohort Study.
      J. Pers. Med. 2022, 12, 1606.
      Tain YL, Liu CL, Kuo HC, Hsu, CN.
    • Fructose milieu undermines the therapeutic effect of Tribulus terrestris extract on neuroblastoma cell line via maintaining mitochondrial function.
      Environ Toxicol. 2022 Nov;37(11):2728-2742.
      Weng JR, Wu CW, Chen YC, Fu MH, Tain YL, Hung CY, Chen IC, Lee CW, Wu KLH.
    • Maternal Supplementation of Probiotics, Prebiotics or Postbiotics to Prevent Offspring Metabolic Syndrome: The Gap between Preclinical Results and Clinical Translation.
      Int J Mol Sci. 2022 Sep 5;23(17):10173.
      Huang YH, Tain YL, Hsu CN.
    • Perinatal Propionate Supplementation Protects Adult Male Offspring from Maternal Chronic Kidney Disease-Induced Hypertension.
      Nutrients. 2022 Aug 21;14(16):3435.
      Tain YL, Hou CY, Chang-Chien GP, Lin SF, Hsu CN.
    • Maternal High-Fat Diet and Offspring Hypertension.
      Int J Mol Sci. 2022 Jul 25;23(15):8179.
      Tain YL, Hsu CN.
    • Novel Insights on Dietary Polyphenols for Prevention in Early-Life Origins of Hypertension: A Review Focusing on Preclinical Animal Models.
      Int J Mol Sci. 2022 Jun 14;23(12):6620.
      Tain YL, Hsu CN.
    • Hypertension of Developmental Origins: Consideration of Gut Microbiome in Animal Models.
      Biomedicines. 2022 Apr 9;10(4):875.
      Tain YL, Hsu CN.
    • Developmental and Early Life Origins of Hypertension: Preventive Aspects of Melatonin.
      Antioxidants (Basel). 2022 May 8;11(5):924.
      Tain YL, Hsu CN.
    • Differences in health-related quality of life in children with chronic kidney disease as reported by children and parent proxies.
      Pediatr Nephrol. 2023 Feb;38(2):519-528.
      Tain YL, Lu PC, Kuo HC, Hsu CN.
    • Microneedle patches integrated with lateral flow cassettes for blood-free chronic kidney disease point-of-care testing during a pandemic.
      Biosens Bioelectron. 2022 Jul 15;208:114234.
      Chen YJ, Hsu YP, Tain YL, Li NS, Pang HH, Kuo SW, Yang HW.
    • Prediction and Clinically Important Factors of Acute Kidney Injury Non-recovery.
      Front Med (Lausanne). 2022 Jan 17;8:789874.
      Liu CL, Tain YL, Lin YC, Hsu CN.
    • Exogenous BMP7 administration attenuated vascular calcification and improved bone disorders in chronic uremic rats.
      Biochem Biophys Res Commun. 2022 Sep 17;621:8-13.
      Lee CT, Kuo WH, Tain YL, Wang Y, Lee WC.
    • Oxidative Stress-Induced Hypertension of Developmental Origins: Preventive Aspects of Antioxidant Therapy.
      Antioxidants (Basel). 2022 Mar 7;11(3):511.
      Tain YL, Hsu CN.
    • Melatonin and Kidney Health: From Fetal Stage to Later Life.
      Int J Mol Sci. 2023, 24, 8105.
      Tan KS, Ho CY, Hsu, CN, Tain YL.
    • Hydrogen Sulfide-to-Thiosulfate Ratio Associated with Blood Pressure Abnormalities in Pediatric CKD.
      J Pers Med. 2022 Jul 29;12(8):1241.
      Hsu CN, Chen WL, Liao WT, Chang-Chien GP, Lin S, Tain YL.
    • Maternal Acetate Supplementation Reverses Blood Pressure Increase in Male Offspring Induced by Exposure to Minocycline during Pregnancy and Lactation.
      Int J Mol Sci. 2022 Jul 18;23(14):7924.
      Hsu CN, Yu HR, Chan JYH, Lee WC, Wu KLH, Hou CY, Chang-Chien GP, Lin S, Tain YL.
    • Sodium butyrate modulates blood pressure and gut microbiota in maternal tryptophan-free diet-induced hypertension rat offspring.
      J Nutr Biochem. 2022 Oct;108:109090.
      Hsu CN, Yu HR, Lin IC, Tiao MM, Huang LT, Hou CY, Chang-Chien GP, Lin S, Tain YL.
    • Chronic Kidney Disease and Gut Microbiota: What Is Their Connection in Early Life?
      Int J Mol Sci. 2022 Apr 2;23(7):3954.
      Hsu CN, Tain YL.
    • The Impact of Gut Microbiome on Maternal Fructose Intake-Induced Developmental Programming of Adult Disease.
      Nutrients. 2022 Feb 28;14(5):1031.
      Hsu CN, Yu HR, Chan JYH, Wu KLH, Lee WC, Tain YL.
    • Impaired insulin signaling at the bladder mucosa facilitates metabolic syndrome-associated bladder overactivity in rats with maternal and post-weaning fructose exposure.
      J Formos Med Assoc. 2022 Oct 4:S0929-6646(22)00363-1.
      Lee WC, Wu KLH, Tain YL, Leu S, Cheng YT, Chan JYH.
    • Dietary Supplementation with Cysteine during Pregnancy Rescues Maternal Chronic Kidney Disease-Induced Hypertension in Male Rat Offspring: The Impact of Hydrogen Sulfide and Microbiota-Derived Tryptophan Metabolites.
      Antioxidants (Basel). 2022 Feb 28;11(3):483.
      Hsu CN, Hou CY, Chang-Chien GP, Lin S, Tain YL.
    • Sodium Thiosulfate Improves Hypertension in Rats with Adenine-Induced Chronic Kidney Disease.
      Antioxidants 2022, 11, 147.
      Hsu CN, Hou CY, Chang-Chien GP, Lin S, Yang HW, Tain YL.
    • Resveratrol Butyrate Ester Protects Adenine-Treated Rats against Hypertension and Kidney Disease by Regulating the Gut–Kidney Axis.
      Antioxidants 2021, 10, 1393.
      Hsu CN, Hou CY, Chang CI, Tain YL.
    • Early-Life Origins of Metabolic Syndrome: Mechanisms and Preventive Aspects.
      Hsu CN, Hou CY, Hsu WH, Tain YL.
      Int. J. Mol. Sci. 2021, 22, 11872.
    • Adverse Impact of Environmental Chemicals on Developmental Origins of Kidney Disease and Hypertension.
      Front Endocrinol. 2021,12:745716
      Hsu CN, Tain YL.
    • The First Thousand Days: Kidney Health and Beyond.
      Healthcare 2021, 9, 1332.
      Hsu CN, Tain YL.
    • Asymmetric Dimethylarginine (ADMA) in Pediatric Renal Diseases: From Pathophysiological Phenomenon to Clinical Biomarker and Beyond.
      Children 2021, 8, 837.
      Hsu CN, Tain YL.
    • Rapid Detection of Gut Microbial Metabolite Trimethylamine N-Oxide for Chronic Kidney Disease Prevention.
      Biosensors 2021, 11, 339.
      Chang YC, Chu YH, Wang CC, Wang CH, Tain YL* and Yang HW*.
    • Maternal Obesity Related to High Fat Diet Induces Placenta Remodeling and Gut Microbiome Shaping That Are Responsible for Fetal Liver Lipid Dysmetabolism.
      Front Nutr. 2021 Dec 15;8:736944.
      Wang YW, Yu HR, Tiao MM, Tain YL, Lin IC, Sheen JM, Lin YJ, Chang KA, Chen CC, Tsai CC, Huang LT.
    • Perinatal Resveratrol Therapy to Dioxin-Exposed Dams Prevents the Programming of Hypertension in Adult Rat Offspring.
      Antioxidants 2021, 10, 1393.
      Hsu CN, Yang HW, Hou CY, Chang-Chien GP, Lin S, Tain YL.
    • Melatonin Prevents Chronic Kidney Disease-Induced Hypertension in Young Rat Treated with Adenine: Implications of Gut Microbiota-Derived Metabolites.
      Hsu CN, Yang HW, Hou CY, Chang-Chien GP, Lin S, Tain YL.
      Antioxidants 2021, 10, 1211.
    • Maternal 3,3-Dimethyl-1-Butanol Therapy Protects Adult Male Rat Offspring against Hypertension Programmed by Perinatal TCDD Exposure.
      Hsu CN, Hou CY, Lee CT, Chang-Chien GP, Lin S, Tain YL.
      Nutrients 2021, 13, 3041.
    • Fat Mass Index Associated with Blood Pressure Abnormalities in Children with Chronic Kidney Disease.
      Children 2021, 8, 621.
      Hsu CN, Lu PC, Tain YL.
    • Gasotransmitters for the Therapeutic Prevention of Hypertension and Kidney Disease.
      Int. J. Mol. Sci. 2021, 22, 7808.
      Hsu CN, Tain YL.
    • Cardiovascular Diseases of Developmental Origins: Preventive Aspects of Gut Microbiota-Targeted Therapy.
      Nutrients. 2021, 13, 2290.
      Hsu CN, Hou CY, Hsu WH, Tain YL.
    • Animal Models for DOHaD Research: Focus on Hypertension of Developmental Origins.
      Biomedicines 2021, 9, 623.
      Hsu CN, Tain YL.
    • Maternal Garlic Oil Supplementation Prevents High-Fat Diet-Induced Hypertension in Adult Rat O?spring: Implications of H2S-Generating Pathway in the Gut and Kidneys.
      Mol Nutr Food Res. 2021, 2001116.
      Hsu CN, Hou CY, Chang-Chien GP, Lin S, Tain YL*.
    • Preventive Aspects of Early Resveratrol Supplementation in Cardiovascular and Kidney Disease of Developmental Origins.
      Int. J. Mol. Sci. 2021, 22, 4210.
      Hsu CN, Hou CY, Tain YL.
    • Altered Gut Microbiota and Its Metabolites in Hypertension of Developmental Origins: Exploring Differences between Fructose and Antibiotics Exposure.
      Int J Mol Sci. 2021 Mar 6;22(5):2674.
      Hsu CN, Chan JYH, Wu KLH, Yu HR, Lee WC, Hou CY, Tain YL.
    • Maternal Resveratrol Therapy Protected Adult Rat Offspring against Hypertension Programmed by Combined Exposures to Asymmetric Dimethylarginine and Trimethylamine-N-oxide: Resveratrol and gut microbiota in programmed hypertension.
      J Nutr Biochem. 2021 Mar 30:108630.
      Hsu CN, Hou CY, Chang-Chien GP, Lin S, Chan JYH, Lee CT, Tain YL.
    • Targeting the Renin–Angiotensin–Aldosterone System to Prevent Hypertension and Kidney Disease of Developmental Origins.
      Int J Mol Sci. 2021;22:2298.
      Hsu CN, Tain YL.
    • Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?
      Antioxidants. 2021, 10, 247.
      Hsu CN, Tain YL.
    • Changing trends in dialysis modalities utilization and mortality in children, adolescents and young adults with acute kidney injury, 2010-2017.
      Sci Rep. 2021 Jun 4;11(1):11887.
      Tain YL, Kuo HC, Hsu CN.
    • Synthesis of Short?Chain?Fatty?Acid Resveratrol Esters and Their Antioxidant Properties.
      Antioxidants 2021, 10, 420.
      Tain YL, Chang SKC, Liao JX, Chen YW, Huang HT, Li YL, Hou CY.
    • Hypertension Programmed by Perinatal High-Fat Diet: E?ect of Maternal Gut Microbiota-Targeted Therapy.
      Nutrients 2019, 11(12): E2908.
      Hsu CN, Hou CY, Chan JYH, Lee CT, Tain YL*.
    • Association of Trimethylamine, Trimethylamine N-oxide, and Dimethylamine with Cardiovascular Risk in Children with Chronic Kidney Disease.
      J Clin Med. 2020 Jan 25;9(2). pii: E336.
      Hsu CN, Chang-Chien GP, Lin S, Hou CY, Lu PC, Tain YL*.
    • Whether AICAR in Pregnancy or Lactation Prevents Hypertension Programmed by High Saturated Fat Diet: A Pilot Study
      Nutrients 2020, 12, 448
      Wan-Long Tsai, Chien-Ning Hsu, You-Lin Tain*
    • Machine Learning Model for Risk Prediction of Community-Acquired Acute Kidney Injury Hospitalization From Electronic Health Records: Development and Validation Study.
      J Med Internet Res 22(8):e16903, 2020.
      Hsu CN, Liu CL, Tain YL, Kuo CY, Lin YC.
    • Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease.
      Int J Mol Sci. 2020, 21, 2232.
      Hsu CN, Tain YL
    • Early-Life Programming and Reprogramming of Adult Kidney Disease and Hypertension: The Interplay between Maternal Nutrition and Oxidative Stress
      Int J Mol Sci. 2020, 21, 3572.
      Hsu CN, Tain YL
    • Targeting on gut microbial metabolite trimethylamine-n-oxide (TMAO) and short chain fatty acid to prevent maternal high-fructose diet-induced developmental programming of hypertension in adult male offspring.
      Mol Nutr Food Res. 63, 1900073, 2019
      Hsu CN, Chang-Chien GP, Lin S, Hou CY, Tain YL*.
    • Utility of human leukocyte antigen-B*58: 01 genotyping and patient outcomes.
      Pharmacogenet Genomics. 2019; 29 (1):1-8.
      Ke CH, Chung WH, Tain YL, Huang YB, Wen YH, Chuang HY, Hsu CN.
    • Pioglitazone reversed the fructose-programmed astrocytic glycolysis and oxidative phosphorylation of female rat offspring.
      Am J Physiol Endocrinol Metab. 316(4):E622-E634, 2019.
      Wu CW, Hung CY, Hirase H, Tain YL, Lee WC, Chan JYH, Fu MH, Chen LW, Liu WC,Liang CK, Ho YH, Kung YC, Leu S, Wu KL.
    • Perinatal Use of Melatonin for O?spring Health: Focus on Cardiovascular and Neurological Diseases.
      Int. J. Mol. Sci. 2019, 20, 5681
      Hsu CN, Huang LT, Tain YL*.
    • The impact of adoption of a new urate-lowering agent on trends in utilization and cost in practice.
      PLoS One. 2019 Aug 26;14(8):e0221504.
      Peng YL, Lee CT, Tain YL, Huang YB, Chuang HY, Wen YH, Huang SH, Tsai CY, Hsu CN.
    • The association between nitric oxide pathway, blood pressure abnormalities, and cardiovascular risk profile in pediatric chronic kidney disease.
      Int. J. Mol. Sci. 2019, 20, 5301
      Hsu CN, Lu PC, Lo MH, Lin IC, Tan YL*.
    • Maternal Exposure to Bisphenol A Combined with High-Fat Diet-Induced Programmed Hypertension in Adult Male Rat Offspring: Effects of Resveratrol.
      Int. J. Mol. Sci. 2019, 20, 4382
      Hsu CN, Lin YJ, Yu HR, Lin IC, Sheen JM, Huang LT, Tain YL*.
    • Protection of Male Rat Offspring against Hypertension Programmed by Prenatal Dexamethasone Administration and Postnatal High-Fat Diet with the Nrf2 Activator Dimethyl Fumarate during Pregnancy.
      Int. J. Mol. Sci. 2019, 20, 3957
      Hsu CN, Lin YJ, Yu HR, Lin IC, Sheen JM, Huang LT, Tain YL*.
    • Blood pressure abnormalities associated with gut microbiota-derived short chain fatty acids in children with congenital anomalies of the kidney and urinary tract.
      J. Clin. Med. 2019, 8, 1090.
      Hsu CN, Lu PC, Hou CY, Tain YL*.
    • Impact of Arginine Nutrition and Metabolism during Pregnancy on O?spring Outcomes.
      Nutrients 2019, 11, 1452
      Hsu CN, Tain YL*.
    • Maternal high-fat diet sex-specifically alters placental morphology and transcriptome in rats: Assessment by next-generation sequencing.
      Placenta. 2019;78:44-53.
      Lin YJ, Huang LT, Tsai CC, Sheen JM, Tiao MM, Yu HR, Lin IC, Tain YL.
    • The Good, the Bad, and the Ugly of Pregnancy Nutrients and Developmental Programming of Adult Disease.
      Nutrients 2019, 11, 894.
      Hsu CN, Tain YL*.
    • Resveratrol prevents combined prenatal NG-Nitro-L-arginine-methyl ester (L-NAME) treatment plus postnatal high-fat diet induced programmed hypertension in adult rat offspring: Interplay between nutrient-sensing signals, oxidative stress and gut microbiota.
      J Nutr Biochem. 2019, 70, 28-37.
      Chen HE, Lin YJ, Lin IC, Yu HR, Sheen JM, Tsai CC, Huang LT, Tain YL.
    • Adherence to long-term use of renin-angiotensin II-aldosterone system inhibitors in children with chronic kidney disease.
      BMC Pediatr. 2019 Feb 20;19(1):64.
      Hsu CN, Huang SH, Tain YL*.
    • Evaluation of endothelial dysfunction, endothelial plasma markers, and traditional metabolic parameters in children with adiposity.
      J Formos Med Assoc. 118: 83-91, 2019
      Lo MH, Lin IC, Lu PC, Huang CF, Chien SJ, Hsieh KS, Tain YL*.
    • The Impact of Maternal Fructose Exposure on Angiogenic Activity of Endothelial Progenitor Cells and Blood Flow Recovery After Critical Limb Ischemia in Rat Offspring.
      Int J Mol Sci. 2019, 20, E2429.
      Leu S, Wu KLH, Lee WC, Tain YL, Chan JYH.
    • Obesity programmed by prenatal dexamethasone and postnatal high-fat diet leads to distinct alterations in nutrition sensory signals and circadian-clock genes in visceral adipose tissue.
      Lipids Health Dis. 2019;18(1):19.
      Tsai CC, Tiao MM, Sheen JM, Huang LT, Tain YL, Lin IC, Lin YJ, Lai YJ, Chen CC, Chang KA, Yu HR.
    • The Effects of Resveratrol in the Treatment of Metabolic Syndrome.
      Int J Mol Sci. 2019 Jan 28;20(3).
      Hou CY, Tain YL, Yu HR, Huang LT.
    • Regulation of Leptin Methylation Not via Apoptosis by Melatonin in the Rescue of Chronic Programming Liver Steatosis.
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    • Utility of human leukocyte antigen-B*58: 01 genotyping and patient outcomes.
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    • Mortality Risks among Various Primary Renal Diseases in Children and Adolescents on Chronic Dialysis.
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    • Regulation of Nitric Oxide Production in the Developmental Programming of Hypertension and Kidney Disease.
      Int J Mol Sci 2018, 20, 681.
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    • The Double-edged Sword Effects of Maternal Nutrition in Developmental Programming of Hypertension.
      Nutrients 10:1917, 2018
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    • Gut Microbiota-Dependent Trimethylamine N-Oxide Pathway Associated with Cardiovascular Risk in Children with Early-Stage Chronic Kidney Disease.
      Int J Mol Sci 2018, 19, 3699.
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    • Maternal Administration of Probiotic or Prebiotic Prevents Male Adult Rat Offspring against Developmental Programming of Hypertension Induced by High Fructose Consumption in Pregnancy and Lactation.
      Nutrients 10:1229, 2018
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    • Maternal Resveratrol Therapy Protects Male Rat Offspring against Programmed Hypertension Induced by TCDD and Dexamethasone Exposures: Is It Relevant to Aryl Hydrocarbon Receptor?
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    • Hydrogen Sul?de in Hypertension and Kidney Disease of Developmental Origins.
      Int J Mol Sci 2018, 19, 1438
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    • Postnatal high-fat diet sex-specifically exacerbates prenatal dexamethasone-induced hypertension: Mass spectrometry-based quantitative proteomic approach.
      J Nutr Biochem. 57:268-275, 2018
      Hsu, CN, Lai WT, Lin YJ, Tain YL*.
    • EQ-5D-Y for the assessment of health-related quality of life among Taiwanese youth with mild-to-moderate chronic kidney diseas.
      Int J Qual Health Care. 30(4): 298-305, 2018.
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    • Translational insights on developmental origins of metabolic syndrome: focus on fructose consumption.
      Biomedical J. 41(2):96-101, 2018
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    • Maternal Melatonin Therapy Attenuates Methyl-Donor Diet-Induced Programmed Hypertension in Male Adult Rat Offspring.
      Nutrients. 2018 Oct 2;10(10), E1407.
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    • Developmental Programming of the Metabolic Syndrome: Can We Reprogram with Resveratrol?
      Int J Mol Sci 2018, 19, 2854
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    • AMP-Activated Protein Kinase as a Reprogramming Strategy for Hypertension and Kidney Disease of Developmental Origin.
      Int J Mol Sci 2018, 19, 1744
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    • Resveratrol prevents the development of hypertension programmed by maternal plus post-weaning high-fructose consumption through modulation of oxidative stress, nutrient-sensing signals, and gut microbiota.
      Mol Nutr Food Res. 62(15): e1800066, 2018
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    • Epidemiology and outcomes of community-acquired and hospital-acquired acute kidney injury in children and adolescents.
      Pediatr Res. 83(3):622-629, 2018
      Hsu CN, Chen HL, Tain YL*.
    • Early postweaning treatment with dimethyl fumarate prevents prenatal dexamethasone and postnatal high fat diet induced programmed hypertension in male rat offspring
      Oxid. Med. Cell Longev. 2018, Volume 2018, Article ID 5343462.
      Lin YJ, Lin IC, Yu HR, Sheen JM, Huang LT, Tain YL*.
    • Maternal Melatonin Therapy Attenuated Maternal High-Fructose Combined with Post-weaning High-Salt Diets-Induced Hypertension in Adult Male Rat Offspring.
      Molecules 23, 886, 2018
      Tain YL, Leu S, Lee WC, Wu K, Chan JYH.
    • Early supplementation of D-cysteine or L-cysteine prevents hypertension and kidney damage in spontaneously hypertensive rats exposed to high-salt intake.
      Mol Nutr Food Res. 62(2):1700596, 2018.
      Hsu CN, Lin YJ, Lu PC, and Tain YL*.
    • Maternal high fructose intake increases the vulnerability to post-weaning high-fat diet induced programmed hypertension in male offspring.
      Nutrients 10:56, 2018
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    • Prenatal metformin therapy attenuates hypertension of developmental origin in male adult offspring exposed to maternal high-fructose and post-weaning high-fat diets.
      Int. J. Mol. Sci. 19(4). pii: E1066, 2018
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    • Early short-term treatment with exogenous hydrogen sulfide postpones the transition from prehypertension to hypertension in spontaneously hypertensive rat.
      Clin Exp Hypertens. 40(1): 58-64, 2018
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    • Potential Orphan Drug Therapy of Intravesical Liposomal Onabotulinumtoxin-A for Ketamine-Induced Cystitis by Mucosal Protection and Anti-inflammation in a Rat Model.
      Sci Rep. 2018 Apr 11;8(1):5795.
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    • Combined maternal and postnatal high-fat diet leads to metabolic syndrome and is effectively reversed by resveratrol: a multipleorgan study.
      Sci Rep. 8:5607, 2018
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    • Prenatal dexamethasone and postnatal high-fat diet have a synergistic effect of elevating blood pressure through a distinct programming mechanism of systemic and adipose renin-angiotensin systems.
      Lipids Health Dis. 2018 Mar 14;17(1):50.
      Yu HR, Tain YL, Tiao MM, Chen CC, Sheen JM, Lin IC, Li SW, Tsai CC, Lin YJ, Hsieh KS, Huang LT.
    • A maternal high-fat diet during pregnancy and lactation, in addition to a postnatal high-fat diet, leads to metabolic syndrome with spatial learning and memory deficits: beneficial effects of resveratrol.
      Oncotarget 2017;8(67):111998-112013.
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    • Detrimental effect of maternal and post-weaning high-fat diet on the reproductive function in the adult female offspring rat: roles of insulin-like growth factor 2 and the ovarian circadian clock.
      J Assist Reprod Genet 34:817-26, 2017
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    • Maternal melatonin or agomelatine therapy prevents programmed hypertension in male offspring of mother exposed to continuous light.
      Biol Reprod. 97(4): 636-643, 2017
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    • Cost-effectiveness Analysis for Genotyping before Allopurinol Treatment to Prevent Severe Cutaneous Adverse Drug Reactions.
      J Rheumatol. 151476, 2017
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    • High Fat Diets Sex-Specifically Affect the Renal Transcriptome and Program Obesity, Kidney Injury, and Hypertension in the Offspring.
      Nutrients. 9(4). pii: E357, 2017.
      Tain YL, Lin YJ, Sheen JM, Yu HR, Tiao MM, Chen CC, Tsai CC, Huang LT, Hsu CN.
    • Toxic Dimethylarginines: Asymmetric Dimethylarginine (ADMA) and Symmetric Dimethylarginine (SDMA).
      Toxins (Basel). 2017 Mar 6;9(3). pii: E92
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    • Developmental Programming of Adult Disease: Reprogramming by Melatonin?
      Int J Mol Sci. 18, 426, 2017
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    • Developmental Origins of Chronic Kidney Disease: Should We Focus on Early Life?
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      Nutrients 8, 757, 2016
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      Int J Mol Sci. 17, 2020, 2016
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      Wu KL, Wu CW, Tain YL, Chao YM, Hung CY, Tsai PC, Wang WS, Shih CD.
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      Int J Mol Sci. 2016 Sep 22;17(10). pii: E1610.
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      Sheng Li Xue Bao. 2016 Oct 25;68(5):557-567.
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    • Melatonin Alleviates Liver Apoptosis in Bile Duct Ligation Young Rats.
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    • Maternal melatonin or N-acetylcysteine therapy regulates hydrogen sulfide-generating pathway and renal transcriptome to prevent prenatal NG-Nitro-L-arginine-methyl ester (L-NAME)-induced fetal programming of hypertension in adult male offspring.
      Am J Obstet Gynecol. 2016, 215(5): 636.e1-e72
      Tain YL, Lee CT, Chan JY, Hsu CN*.
    • Targeting arachidonic acid pathway to prevent programmed hypertension in maternal fructose-fed male adult rat offspring.
      J Nutr Biochem 38:86-92, 2016
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      Steroids 115: 40-46, 2016
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    • Combined intraperitoneal and intrathecal etanercept reduce increased brain tumor necrosis factor-alpha and asymmetric dimethylarginine levels and rescues spatial deficits in young rats after bile duct ligation.
      Front. In Cellular Neuroscience 10:167, 2016
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    • Aliskiren administration during early postnatal life sex-specifically alleviates hypertension programmed by maternal high fructose consumption.
      Front Physiol. 7:299, 2016
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    • N-acetylcysteine prevents programmed hypertension in male offspring born to suramin-treated mothers.
      Biol Reprod. 95(1):8, 1–8 , 2016
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    • Postnatal high-fat diet leads to spatial deficit, obesity, and central and peripheral inflammation in prenatal dexamethasone adult offspring rats.
      Neuroreport 27(11):818-8, 2016.
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    • Incidence and Risks of Congenital Anomalies of Kidney and Urinary Tract in Newborns: A Population-Based Case-Control Study in Taiwan.
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    • Early postnatal treatment with soluble epoxide hydrolase inhibitor or 15-Deoxy-Δ12,14-prostagandin J2 prevents prenatal dexamethasone and postnatal high saturated fat diet induced programmed hypertension in adult rat offspring.
      Prostaglandins Other Lipid Mediat 124:1-8, 2016
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      Steroids 108:1-6, 2016
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      Neurobiol Learn Mem. 130:105-117, 2016
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    • Ba-Wei-Die-Huang-Wan (Hachimi-jio-gan) Can Ameliorate Cyclophosphamide-induced Ongoing Bladder Overactivity and Acidic Adenosine Triphosphate Solution-induced Hyperactivity on Rats Prestimulated Bladder.
      J Ethnopharmacol. 184:1-9, 2016.
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    • Postnatal high-fat diet increases liver steatosis and apoptosis threatened by prenatal dexamethasone through the oxidative effect.
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    • Low urinary citrulline/arginine ratio associated with blood pressure abnormalities and arterial stiffness in childhood chronic kidney disease.
      J Am Soc Hypertens 10(2):115-23, 2016
      Lin IC, Hsu CN, Lo MH, Chien SJ, Tain YL*.
    • Compliance with risk management plan recommendations on laboratory monitoring of antitumor necrosis factor-α therapy in clinical practice.
      J Formos Med Assoc. 115: 83-93, 2016
      Chan MJ, Huang TB, Wen YH, Chuang HY, Tain YL, Wang YC, Hsu CN.
    • Early and late effects of prenatal corticosteroid treatment on the microRNA profiles of lung tissue in rats.
      Exp Ther Med. 11: 753-762, 2016
      Yu HR, Li SC, Tseng WN, Tain YL*, Chen CC, Tiao MM, Kuo HC, Huang CC, Hsieh KS, Huang LT*.
    • Maternal N-acetylcysteine therapy Regulates Hydrogen Sulfide-generating Pathway and Prevents Programmed Hypertension in Male Offspring Exposed to Prenatal Dexamethasone and Postnatal High-Fat Diet.
      Nitric Oxide 53: 6-12, 2016.
      Tai IH, Sheen JM, Lin YJ, Yu HR, Tiao MM, Chen CC, Huang LT, Tain YL*.
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      Int J Mol Sci. 17(1):23, 2016
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    • PPARs link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome.
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    • High salt exacerbates programmed hypertension in maternal fructose-fed male offspring.
      Nutr Metab Cardiovas Dis. 25(12): 1146–1151, 2015
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      Science Bulletin 60(16): 1416-25, 2015.
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    • Homocysteine and arginine-to-asymmetric dimethylarginine ratio associated with blood pressure abnormalities in children with early chronic kidney disease.
      Cir J 79: 2031-7, 2015
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    • Renal Transcriptome Analysis of Programmed Hypertension Induced by Maternal Nutritional Insults.
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      Dev Neurosci. 37(2):105-14, 2015
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    • Asymmetric and Symmetric Dimethylarginine Are Associated with Coronary Artery Lesions in Kawasaki Disease.
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      Immunology. 143(2):184-92, 2014
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      Immunology. 143(4):651-60, 2014
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      Oxidative Medicine and Cellular Longevity Volume 2014, Article ID 283180
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    • Maternal citrulline supplementation prevents prenatal dexamethasone-induced programmed hypertension.
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      Eur J Pharmacol 699:233-40, 2013
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    • Alterations in NADPH oxidase expression and blood-brain barrier in bile duct ligation-treated young rats: effects of melatonin.
      Neurochem Int. 2012 Jun;60(8):751-8.
      Chen YC, Sheen JM, Tain YL, Chen CC, Tiao MM, Huang YH, Hsieh CS, Huang LT.
    • Arginine and asymmetric dimethylarginine in puromycin aminonucleoside-induced chronic kidney disease in the rat.
      Am J Nephrol. 35: 40-8, 2012.
      Chen GF, Moningka NC, Sasser JM, Zharikov S, Cunningham M Jr, Tain YL, Schwartz IF, Baylis C.
    • Melatonin utility in neonates and children.
      J Formos Med Assoc. 111: 57-66, 2012.
      Chen YC, Tain YL, Sheen JM, Huang LT.
    • Urinary arginine methylation index associated with ambulatory blood pressure abnormalities in children with chronic kidney disease. J Am Soc Hypertens, 6: 385-92, 2012.
      J Am Soc Hypertens, 6: 385-92, 2012.
      Kuo HC, Hsu CN, Huang CF, Lo MH, Chien SJ, Tain YL*.
    • Endotoxemia exacerbates kidney injury and increases asymmetric dimethylarginine in young bile duct-ligated rats.
      Shock. 37: 441-8, 2012.
      Huang LT, Hung JF, Chen CC, Hsieh CS, Yu HR, Hsu CN, Tain YL*.
    • The combined ratios of L-arginine, asymmetric and symmetric dimethylarginine as biomarkers in spontaneously hypertensive rats.
      Transl Res, 159:90-98, 2012
      Hsu CN, Huang LT, Lau YT, Lin CY, Tain YL*.
    • Apocynin attenuates oxidative stress and hypertension in young spontaneously hypertensive rats independent of ADMA/NO pathway.
      Free Radical Res. 46: 68-76, 2012
      Tain YL*, Hsu CN, Huang LT, Lau YT.
    • Identification of immunodeficient molecules in neonatal mononuclear cells by proteomic differential displays.
      Proteomics. 11:3491-500, 2011.
      Yu HR, Kuo HC, Huang HC, Kuo HC, Chen TY, Huang LT, Tain YL, Chen CC, Sheen JM, Lin IC, Ou CY, Hsu TY, Jheng YJ, Yang KD.
    • Prenatal stress in rat causes long-term spatial memory deficit and hippocampus MRI abnormality: differential effects of postweaning enriched environment.
      Neurochem Int. 58:434-41, 2011
      Lui CC, Wang JY, Tain YL, Chen YC, Chang KA, Lai MC, Huang LT.
    • GAPDH is a reliable internal control in western blot analysis of leukocyte subpopulations from children.
      Anal Biochem. 413: 24-9, 2011.
      Yu HR, Kuo HC, Huang HC, Huang LT, Tain YL, Chen CC, Liang CD, Sheen JM, Lin IC, Wu CC, Ou CY, Yang KD.
    • Carbon dioxide pneumoperitoneum induces anti-inflammatory response and hepatic oxidative stress in young rats with bacterial peritonitis.
      Pediatr Surg Int. 27(3):289-94, 2011
      Hsieh CS, Tain YL, Chen YC, Chang K, Jean YH, Huang LT.
    • Urachal Catheter Provides New Choice for Long-term Urinary Diversion in Prune Belly Syndrome.
      Urology 77(2):466-8, 2011
      Chen IL, Huang HC, Lee SY, Liu CA, Tain YL, Ou-Yang MC, Chao PH.
    • Aliskiren prevents hypertension and reduces asymmetric dimethylarginine in young spontaneously hypertensive rats.
      Eur J Pharmacol 670:561-565, 2011
      Tain YL*, Hsu CN, Lin CY, Huang LT, Lau YT.
    • Asymmetric dimethylarginine: Clinical applications in pediatric medicine.
      J Formos Med Assoc. 110(2):70-77, 2011
      Tain YL*, Huang LT.
    • Ectopic pelvic kidney with urinary tract infection presenting as lower abdominal pain in a child.
      Pediatr Neonatol. 52:117-20, 2011.
      Lu CC, Tain YL, Yeung KW, Tiao MM.
    • Reciprocal changes of renal neuronal nitric oxide synthase-α and -β associated with renal progression in a neonatal 5/6 nephrectomized rat model.
      Pediatr Neonatol 52:66-72, 2011.
      Tain YL*, Ghosh S, Krieg RJ, Baylis C.