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醫療團隊

專業的醫護人員，提供最佳的醫療服務

醫師介紹

  •

黃玄贏醫師

骨骼與軟組織病理、分子病理、頭頸部腫瘤病理
  • 國語,英語,閩南語
  • 教授
醫師資歷
  • 現職
    • 教授級主治醫師
  • 學歷
    • 高雄醫學院醫學系畢業, 1993
  • 經歷
    • 1995~1995 高雄醫學大學附設醫院腦神經內科住院醫師
    • 1995~1999 高雄長庚紀念醫院病理科住院醫師
    • 1999~迄今 高雄長庚紀念醫院解剖病理科主治醫師
    • 2001~2003 美國Sloan-Kettering癌症中心骨骼與軟組織病理學研究員
    • 2004~2006 樹人醫護管理專科學校病理學兼任助理教授
    • 2006~2009 長庚大學醫學院病理學專任助理教授
    • 2009~2011 長庚大學醫學院病理學專任副教授
  • 學會與認證
    • 99年台灣病理學會-葉曙基金會最佳論文獎
    • 98年行政院國科會吳大猷先生紀念獎
    • 臺灣病理學會分子病理教育委員
    • 臺灣病理學會/衛生署國民健康局骨骼軟組織病理諮詢委員
    • 臺灣病理學會理事(2011~2014)
    • 國科會解剖、法醫、病理組複審委
  • 論文及期刊發表
    • Huang SC, Chang IYF, Chang CJ, Liu H, Chen KH, Liu TT, Hsieh TY, Chuang HC, Chien-Cheng Chen, Lin IC, Ng KF, Huang HY*, Chen TC*. Association between hepatic angiosarcoma and end-stage renal disease: nationwide population-based evidence and enriched mutational signature of aristolochic acid exposure. J Pathol. (co-corresponding author)

    • Li CF, Chan TC, Wang CI, Fang FM, Lin PC, Yu SC, Huang HY*. RSF1 requires CEBP/ β and hSNF2H to promote IL-1β-mediated angiogenesis: The clinical and therapeutic relevance of RSF1 overexpression and amplification in myxofibrosarcomas. Angiogenesis. 2021 Aug;24(3):533-548

    • Wang JC, Li WS*, Kao YC, Lee JC, Lee PH, Huang SC, Tsai JW, Chen CC, Chang CD, Yu SC, Huang HY*. Clinicopathologic and molecular characterization of USP6-rearranged soft tissue neoplasms: The evidence of genetic relatedness indicates an expanding family with variable bone-forming capacity. Histopathology. 2021 April:78.676-689 (2016 IF: 3.523, rank: 15/79 =19.0 % in Pathology, co-corresponding author)

    • Lee JC*, Li WS, Kao YC, Chung YC, Huang HY*. Toward a unifying entity that encompasses most, but perhaps not all, inflammatory leiomyosarcomas and histiocyte-rich rhabdomyoblastic tumors. Mod Pathol 2021 Mar 24. doi: 10.1038/s41379-021-00797-8. (co-corresponding author) (IF=5.988, ranking 6/78=7.7% in pathology)

    • Li CF, Chan TC, Wang CI, Fang FM, Lin PC, Yu SC, Huang HY*. RSF1 requires CEBP/ β and hSNF2H to promote IL-1β-mediated angiogenesis: The clinical and therapeutic relevance of RSF1 overexpression and amplification in myxofibrosarcomas. Angiogenesis. 2020 (Accepted, in press) (IF=9.780, ranking 3/65=4.6% in peripheral vascular disease)

    • Liau JY, Tsai JH, Lan J, Chen CC, Wang YH, Lee JC, Huang HY.* GNA11 joins GNAQ and GNA14 as a recurrently mutated gene in anastomosing hemangioma. Virchows Arch. 2019 Nov 9. doi: 10.1007/s00428-019-02673-y. [Epub ahead of print] (corresponding author)

    • Lee JC, Huang HY.* Soft Tissue Special Issue: Giant Cell-rich Lesions of the Head and Neck. Head and neck Pathol 2019 doi.org/10.1007/s12105-019-01086-2 Review. (corresponding author)

    • Kao YC, Lee JC, Huang HY*. What is new about the molecular genetics in matrix-producing soft tissue tumors? -The contributions to pathogenetic understanding and diagnostic classification. Virchows Arch. 2019 Nov 7. doi: 10.1007/s00428-019-02679-6. [Epub ahead of print] Review. (corresponding author)

    • Tsai JW, ChangChen W#, Lee JC#,Kao YC4,11,#, Li WS, Liang CW, Liao IC, Yi-Ming Chang YM, Wang RZ, Tsao CF, Yu SC, Huang HY* The expanding morphological and genetic spectra of MYOD1-mutant spindle cell/sclerosing rhabdomyosarcomas: a clinicopathological and molecular comparison of mutated and nonmutated cases. Histopathology (SCI in press, 2016 IF: 3.523, rank: 15/79 =19.0 % in Pathology, corresponding author)

    • Li CF, Liu TT, Wang JC, Yu SC, Chen YY, Fang FM, Wan-Shan Li WS, Huang HY* Hydroxysteroid 11-beta dehydrogenase 1 overexpression with copy-number gain and missense mutations in primary gastrointestinal stromal tumors. J Clin Med. 2018 Nov 1;7(11). pii: E408.

    • Huang SC, Huang HY. Solitary Fibrous Tumor: An Evolving and Unifying Entity with Unsettled Issues. Histology and Histopathology 2018 (SCI invited review in press, 2017 IF: 2.015, rank: 40/79 =50.6% in Pathology, corresponding author*).

    • Li CF, Liu TT, Wang JC, Yu SC, Chen YY, Fang FM, Li Ws, Huang HY. Hydroxysteroid 11- dehydrogenase 1 overexpression with copy-number gain and missense mutations in primary gastrointestinal stromal tumors. J Clin Med. 2018 Nov 1;7(11). pii: E408. doi: 10.3390/jcm7110408 (SCI, IF=5.583; General & internal, corresponding author*)

    • Li CF, Fang FM, Chen YY, Liu TT, Chan TC, Yu SC, Chen LT, Huang HY*.. Overexpressed fatty acid synthase in gastrointestinal stromal tumors: Targeting a progression-associated metabolic driver enhances the antitumor effect of imatinib. Clin Cancer Res 2017 Apr 25. pii: clincanres.2770.2016. doi: 10.1158/1078-0432. (SCI, 2016 IF: 9.619, rank, 12/217=5.5 % in Oncology, corresponding author*).

    • Li CF, Liu TT, Chuang IC, Chen YY, Fu-Min Fang FM, Chan TC, Li WS, Huang HY*. PLCB4 copy gain and PLCs4 overexpression in primary gastrointestinal stromal tumors: integrative characterization of a lipid-catabolizing enzyme associated with worse disease-free survival. Oncotarget. 2017 Feb 13. doi: 10.18632/oncotarget.15306

    • Yuan CT, Huang WC, Lee CH, Lin MC, Lee CH, Kao YC, Huang HY, Kuo KT, Lee JC. Comprehensive Screening for MED12 Mutations in Gynecological Mesenchymal Tumors Identified Morphologically Distinctive Mixed Epithelial and Stromal Tumors. Histopathology. 2016 Dec 21. doi: 10.1111/his.13156. [Epub ahead of print] (SCI, 2016 IF: 3.523, rank: 15/79 =19.0 % in Pathology, corresponding author)

    • Li CF, Chuang IC,Liu TT, Chen KC, Chen YY, Fang FM,Li SH, Chen TJ, Yu SC,Lan J,Huang HY Transcriptomic reappraisal identifies MGLL overexpression as an unfavorable prognosticator in primary gastrointestinal stromal tumors Oncotarget. 2016 Aug 2;7(31):49986-49997. (SCI, 2014 IF: 6.359, rank: 20/211 =9.5 % in Oncology, corresponding author)

    • Li WS, Liao IC, Wen MC, Lan HH, Yu SC, Huang HY.BCOR-CCNB3-Positive Soft Tissue Sarcoma with Round and Spindle Histology: A Series of 4 Cases Highlighting the Pitfall of Mimicking Poorly Differentiated Synovial Sarcoma.Histopathology. 2016; 69: 792–801. (SCI, 2014 IF: 3.453, rank: 15/75 =20.0 % in Pathology, corresponding author)

    • Chuang IC, Liao KC, Huang HY, Kao YC, Li CF, Huang SC, Tsai JW, Chen KC, Lan J, Lin PC. NAB2-STAT6 gene fusion and STAT6 immunoexpression in extrathoracic solitary fibrous tumors: the association between fusion variants and locations. Pathol Int2016 May;66(5):288-96. (SCI in press, 2014 IF: 1.691, rank: 46/75 = 61.3% in Pathology, corresponding author)

    • Kao YC, Lin PC, Yen SL, Huang SC, Tsai JW, Li CF, Tai HC, Lan J, Chunag IC, Yu SC, Huang HY*. Clinicopathological and genetic heterogeneity of the head and neck solitary fibrous tumours: a comparative histological, immunohistochemical, and molecular study of 36 cases. Histopathology. 2016 Mar;68(4):492-501. (SCI, 2014 IF: 3.453, rank: 15/75 =20.0 % in Pathology, corresponding author*)

    • Tai HC, Chuang IC, Chen TC, Li CF, Huang SC, Kao YC, Lin PC, Tsai JW, Lan J, Yu SC, Yen SL, Jung SM, Liao KC, Fang FM, Huang HY*. NAB2-STAT6 fusion types account for clinicopathological variations in solitary fibrous tumors: a correlative study of 88 cases. Mod Pathol Jul 31. doi: 10.1038/modpathol.2015.90. [Epub ahead of print] (SCI, in press, 2014 IF: 6.187, rank: 5/75 =6.7 % in Pathology, corresponding author*)

    • Li CF, Chen LT, Lan L, Chou FF, Lin CY, Chen YY, Chen TJ, Li SH, Yu SC, Fang FM, Tai HC, Huang HY*. AMACR amplification and overexpression in primary imatinib-naive gastrointestinal stromal tumors: a driver of cell proliferation indicating adverse prognosis. Oncotarget 2014 Nov 30;5(22):11588-603. (SCI, 2014 IF: 6.359, rank: 20/211 =9.5 % in Oncology, corresponding author*, 第12回日本臨床腫瘍學會最佳論文獎勵賞).

    • Li CF#, Fang FM #, Kung HJ, Chen LT,Wang JW, Tsai JW, Yu SC, Wang YW, Li SH, Huang HY*. Downregulated MTAP Expression in Myxofibrosarcoma: A Characterization of Inactivating Mechanisms, Tumor Suppressive Function, and Therapeutic Relevance. Oncotarget 2014 Nov 30;5(22):11428-41. (SCI, 2014 IF: 6.359, rank: 20/211 =9.5 % in Oncology, corresponding author*).

    • Li CF, Fang FM, J Lan, JW Wang, Kung HJ, Chen LT, TJ Chen, Li SH, Wang YW, HC Tai, Yu SC, HY Huang*. AMACR amplification in myxofibrosarcomas: a mechanism of overexpression that promotes cell proliferation with therapeutic relevance. Clin Cancer Res 2014 Dec;20(23):6141-52. (SCI in press, 2014 IF: 8.722, rank, 12/211=5.7 % in Oncology, corresponding author*)

    • Li CF#, Huang HY#,Wu WR, Liang SS, Chen YL, Chen LR, Peng YT, Lee HC, Shiue YL. Clinical Aggressiveness of Myxofibrosarcomas Associates with Downregulation of p12CDK2AP1: prognostic implication of a putative tumor suppressor that induces cell cycle arrest and apoptosis via mitochondrial pathway. Ann Surg Oncol 2014 Dec;21 Suppl 4:711-20. (SCI in press, # equal contribution, 2014 IF: 3.930, rank: 15/198 =7.6 % in Surgery, co-first author#).

    • Kao YC, Lan J, Tai HC, Li CF, Liu KW, Tsai JW, Fang FM, Yu SC, Huang HY*. Angiomatoid Fibrous Histiocytoma: clinicopathological and molecular characterization with emphasis on variant histomorphology. J Clin Pathol 2014 Mar;67(3):210-5.

    • Huang HY, Wu WR, Wang YH, Wang JW, Fang FM, Tsai JW, Li SH, Hung HC, Yu SC, Lan J, Shiue YL, Hsing CH, Chen LT, Li CF. ASS1 as a Novel Tumor Suppressor Gene in Myxofibrosarcomas: aberrant loss via epigenetic DNA methylation confers aggressive phenotypes, negative prognostic impact, and therapeutic relevance. Clinical Cancer Research 2013 Jun 1;19(11):2861-2872. (SCI 2011 IF: 7.742, rank, 14/196=7.1 % in Oncology)

    • Chien CY, Chuang HC, Chen CH, Fang FM, Chen WC, Huang CC, Huang HY. The Expression of Activin Receptor-Like Kinase 1 among Patients with Head and Neck Cancer. Otolaryngol Head Neck Surg. 2013 Jun;148(6):965-73. (SCI, 2011 IF: 1.718, rank: 11/41 =26.8 % in Otorhinolaryngology).

    • Tsai JW, Li CF, Kao YC, Wang JW, Fang FM,Wang YH, Wu WR, Wu LC, Hsing CH, Li SH, Yu SC, Lan J, Huang HY*. Recurrent amplification at 7q21.2 targets CDK6 gene in primary myxofibrosarcomas and identifies CDK6 overexpression as an independent adverse prognosticator. Ann Surg Oncol 2012;19:2716–2725 (SCI 2010 IF: 4.182, rank: 8/188 =4.3 % in Surgery, corresponding author)

    • Li CF, Wang JM#, Kang HY# , Huang CK,Wang JW, Fang FM, Wang YH, Wu WR, Li SH, Yu SC, Lee JC, Lan J, Shiue YL, Wu LC, Huang HY*. Characterization of Gene Amplification-Driven SKP2 Overexpression in Myxofibrosarcoma: Potential implications in tumor progression and therapeutics. Clinical Cancer Research 2012 Mar; 18(6):1598-1610. (SCI 2011 IF: 7.742, rank, 14/194=7.2 % in Oncology, corresponding author)

    • Tai HC*, Huang HY*, Lee SW, Lin CY, Sheu MJ, Chang SL, Wu LC, Shiue YL, Wu WR, CM, Li CF. Associations of Rsf-1 overexpression with poor therapeutic response and worse survival in patients with nasopharyngeal carcinoma .J Clin Pathol 2012; 65:248-253. (#, equal contribution, SCI, 2010 IF:2.475 , rank: 26/76 =34.2% in Pathology).

    • Li CF#, Fang FM#, Wang JM#, Tzeng CC, Tai HC, Wei YC, Li SH, Lee YT, Wang YH, Yu SC, Shiue YL, Chu PYW, Wang WL, Chen LT, Huang HY*. EGFR nuclear import in gallbladder carcinoma: nuclear phosphorylated EGFR upregulates iNOS expression and confers independent prognostic impact. Ann Surg Oncol 2012 Feb;19(2):443-54. (SCI, 2010 IF: 4.182, rank: 8/188 =4.3 % in Surgery, corresponding author).

    • CF Hwang#, HY Huang#, CH Chen, CY Chien, YC Hsu, CF Li, FM Fang. Enhancer of Zeste Homolog 2 overexpression in nasopharyngeal carcinoma: an independent poor prognosticator that enhances cell growth. Int J Radiat Oncol 2012 Feb 1;82(2):597-604. (#, equal contribution, SCI, 2010 IF: 4.503, rank: 10/113 =8.9% in radiology, nuclear medicine, and medical imaging)

    • Huang HY*, LI CF, Fang FM, Tsai JW, LI SH, Lee YT, Wei HM. Prognostic Implication of Ezrin overexpression in Myxofibrosarcomas. Ann Surg Oncol 2010;17(12):3212-3219. (SCI, 2010 IF: 4.182, 4.3 % in surgery, first and corresponding author)

    • Lee JC, Li CF, Fang FM, Wang JW, Jeng YM, Yu SC, Lin YT, Wu JM, Tsai JW, Li SH, Huang HY*. Prognostic Implication of MET Overexpression in Myxofibrosarcomas: an integrative array comparative genomic hybridization, real-time quantitative PCR, immunoblotting, and immunohistochemical analysis. Mod Pathol 2010;23(10):1379-1392. (SCI, 2010 IF: 4.176, rank: 12/76 =15.8 % in pathology, CMRPG870751-2, corresponding author, 100年台灣病理學會-葉曙基金會最佳論文)

    • Lin HC, Friedman M, Kuo FY, Huang HY* Synovial Sarcoma of the Eustachian Tube. Head Neck.2009;31(9):1245-8. (SCI, 2010 IF: 1.571, rank: 11/41=26.8% in Otorhinolaryngology, corresponding author*)

    • Huang CW#, Lin CY#, Huang HY#, Liu HW, Chen YJ, Shih DF, Chen HY, Juan CC, Ker CG, Huang CYF, Li CF, Shiue YL. The CKS1B overexpression implicates clinical aggressiveness of hepatocellular carcinomas but not p27Kip1 protein turnover: an independent prognosticator with potential p27Kip1 -independent Oncogenic Attributes? Ann Surg Oncol 2010 Mar;17(3):907-22. (#, equal contribution, SCI, 2010 IF: 4.182, rank: 8/188 =4.3 % in Surgery, corresponding author).

    • Wei YC, Li CF, Yu SC, Chou FF, Fang FF, Eng HL, Uen YH, Tian YF, Wu JM, Li SH, Huang WW, Li WW, Huang HY*. Ezrin Overexpression in Gastrointestinal Stromal tumors: an independent adverse prognosticator associated with the non-gastric location. Mod Pathol 2009; 22(10):1351-60 (SCI, 2010 IF: 4.176, rank: 12/76 =15.8 % in pathology, CMRPG850442 and 95-2320-B-182A-007 -MY2, corresponding author)

    • Huang WW$, Huang HY$, Liao AC, Shiue YL, Tai HL, Lin CM, Wang YH, CN Lin, KH Shen, Li CF*. Primary Urothelial Carcinoma of the Upper Tract: Important Clinicopathological Factors Predicting Bladder Recurrence after Surgical Resection. Pathol Int 2009;59(9):642-9. ($, equal contribution, SCI 2010 IF: 1.481, rank: 48/76 = 63.2% in pathology)

    • Huang HY, Li SH, Yu SC, Chou FF, Tzeng CC, Hu TH, Uen YH, Tian YF, Wang YH, Fang FM, Huang WW, Wei YC, Wu JM, Li CF*. Homozygous Deletion of MTAP gene as a Poor Prognosticator in Gastrointestinal Stromal Tumors. Clinical Cancer Research 2009; 15(22): 6963-72. (SCI 2011 IF: 7.742, rank, 14/194=7.2 % in Oncology, NSC 94-2320-B-182A-005, NSC 95-2320-B-182A-007 -MY2, CMRPG850442, 99年台灣病理學會-葉曙基金會最佳論文)

    • Chen HK, Huang WT, Eng HL, Lu HI, Huang HY*. An Ossifying Thymoma Clinically Presenting with Peripheral T-cell Lymphocytosis. Ann Thorac Surg 2009 Jul;88(1):e5-7. (SCI, 2010 IF: 3.792, rank: 11/188=5.9% in Surgery, corresponding author*)

    • Fang FM, Chien CY, Li CF, Shiu WY, Chen CH, Huang HY*. Impact of S-phase kinase-associated protein 2 (Skp2) expression on distant metastasis and survival in patients with nasopharyngeal carcinoma. Int J Radiat Oncol 2009;73(1):202-7. (SCI, 2010 IF: 4.503, rank: 10/113 =8.9% in radiology, nuclear medicine, and medical imaging, corresponding author*, 2009年癌症防治基金會最佳論文)

    • Li CF, Huang WW, Wu JM, Yu SC, Hu TH, Uen YH, Tian YF, Lin CN, Lu D, Fang FM, Huang HY*. Heat Shock Protein 90 Overexpression Independently Predicts Inferior Disease-free Survival with Differential Expression of the α and β Isoforms in Gastrointestinal Stromal Tumors. Clinical Cancer Research 2008, Dec 1; 14(23):7822-31. (SCI 2011 IF: 7.742, rank, 14/194=7.2 % in Oncology, corresponding author, NSC 95-2320-B-182A-007 -MY2, 98年台灣病理學會-葉曙基金會最佳論文)

    • Huang HY, Huang WW, Wu JM, Huang CK, Wang JW, Eng HL, Lin CN, Chou SC, Yu SC, Fang FM, Lee JC, Li CF*. Flow Cytometric Analysis of DNA Ploidy and S-phase Fraction in Primary Localized Myxofibrosarcoma: Correlations with Clinicopathological factors, Skp2 Expression, and Patient survival. Ann Surg Oncol 2008 Aug;15(8):2239-49. (SCI, SCI, 2010 IF: 4.182, rank: 8/188 =4.3 % in Surgery)

    • Huang HY, West RB, Tzeng CC, van de Rijn M, Wang JW, Chou SC, Huang WW, Eng HL, Lin CN, Yu SC, Wu JM, Lu CC, Li CF*. Immunohistochemical and Biogenetic Features of Diffuse-Type Tenosynovial Giant Cell Tumors: the potential roles of cyclin A, P53, and deletion of 15q in sarcomatous transformation. Clinical Cancer Research 2008, Oct; 14(19):6023-6032 (SCI 2011 IF: 7.742, rank, 14/194=7.2 % in Oncology, CMRPG83019-III)