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醫療團隊

專業的醫護人員，提供最佳的醫療服務

醫師介紹

  •

李文欽醫師

一般腎臟學、腎臟替代療法、腎臟移植、腎臟發育、腎臟生理、細胞生物學
  • 國語,英語,閩南語
  • 教授
醫師網路掛號
直接點選進入醫師網路掛號畫面
醫師資歷
  • 現職
    • 腎臟科主任
  • 學歷
    • 英國愛丁堡大學生物醫學博士
    • 台灣大學醫學系醫學士
  • 經歷
    • 腎臟科副科主任
    • 高雄腎臟科主治醫師
  • 學會與認證
    • 台灣內科醫學會
    • 台灣腎臟醫學會
  • 論文及期刊發表
    • Pan HY, Cheng FJ, Huang KC, Kung CT, Huang WT, You HL, Li SH, Wang CC, Lee WC, Hsu PC. Exposure to tris(2-butoxyethyl) phosphate induces abnormal sperm morphology and testicular histopathology in male rats. Ecotoxicol Environ Saf. 2022 Aug;241:113718. (SCI；IF=6.774；Biochemical Research Methods

    • Hsu PC, Liu CH, Lee WC, Wu CH, Lee CT, Su CH, Wang YL, Tsai KF, Chiou TT. Predictors of Acute Kidney Disease Severity in Hospitalized Patients with Acute Kidney Injury. Biomedicines. 2022 May 6;10(5):1081.

    • Lee MG, Lee YK, Huang SC, Chang CL, Ko CY, Lee WC, Chen TY, Tzou SJ, Huang CY, Tai MH, Lin YW, Kung ML, Tsai MC, Chen YL, Chang YC, Wen ZH, Huang CC, Chu TH. DLK2 Acts as a Potential Prognostic Biomarker for Clear Cell Renal Cell Carcinoma Based on Bioinformatics Analysis. Genes (Basel). 2022 Apr 1;13(4):629.

    • Lee WC, Chiu CH, Chu TH, Chien YS. WT1: The Hinge Between Anemia Correction and Cancer Development in Chronic Kidney Disease. Front Cell Dev Biol. 2022 Apr 6;10:876723

    • Chuang PH, Tsai KF, Wang IK, Huang YC, Huang LM, Liu SH, Weng CH, Huang WH, Hsu CW, Lee WC, Yen TH. Blood Aluminum Levels in Patients with Hemodialysis and Peritoneal Dialysis. Int J Environ Res Public Health. 2022 Mar 24;19(7):3885.

    • Tsai KF, Hsu PC, Lee CT, Kung CT, Chang YC, Fu LM, Ou YC, Lan KC, Yen TH, Lee WC*. Association between Enzyme-Linked Immunosorbent Assay-Measured Kidney Injury Markers and Urinary Cadmium Levels in Chronic Kidney Disease. J Clin Med. 2021 Dec 29;11(1):156.

    • Ng HY, Leung FF, Kuo WH, Lee WC, Lee CT*. Dapagliflozin and xanthine oxidase inhibitors improve insulin resistance and modulate renal glucose and urate transport in metabolic syndrome. Clin Exp Pharmacol Physiol. 2021 Dec;48(12):1603-1612.

    • Huang CC, Chou CA, Chen WY, Yang JL, Lee WC, Chen JB, Lee CT, Li LC*. Empagliflozin Ameliorates Free Fatty Acid Induced-Lipotoxicity in Renal Proximal Tubular Cells via the PPARγ/CD36 Pathway in Obese Mice. Int J Mol Sci. 2021 Nov 17;22(22):12408

    • Tsai KF, Hsu PC, Kung CT, Lee CT, You HL, Huang WT, Li SH, Cheng FJ, Wang CC, Lee WC*. The Risk Factors of Blood Cadmium Elevation in Chronic Kidney Disease. Int J Environ Res Public Health. 2021 Nov 24;18(23):12337.

    • Ng HY, Kuo WH, Tain YL, Leung FF, Lee WC, Lee CT*. Effect of Dapagliflozin and Magnesium Supplementation on Renal Magnesium Handling and Magnesium Homeostasis in Metabolic Syndrome. Nutrients. 2021 Nov 15;13(11):4088.

    • Chiou TT, Chau YY, Chen JB, Hsu HH, Hung SP, Lee WC*. Rapamycin attenuates PLA2R activation-mediated podocyte apoptosis via the PI3K/AKT/mTOR pathway. Biomed Pharmacother. 2021 Oct 23;144:112349.

    • Li LC, Chen WY, Chen JB, Lee WC, Chang CC, Tzeng HT, Huang CC, Chang YJ, Yang JL. The AST-120 Recovers Uremic Toxin-Induced Cognitive Deficit via NLRP3 Inflammasome Pathway in Astrocytes and Microglia. Biomedicines. 2021 Sep 17;9(9):1252.

    • Tsai KF, Chen YL, Chiou TT, Chu TH, Li LC, Ng HY, Lee WC*, Lee CT. Emergence of SGLT2 Inhibitors as Powerful Antioxidants in Human Diseases. Antioxidants (Basel). 2021 Jul 22;10(8):1166.

    • Liu YW, Hsu YT, Lee WC, Tsai MY. Review of Traditional Chinese Medicines for Common Complications Related to Hemodialysis: An Evidence-Based Perspective. Evid Based Complement Alternat Med. 2021 Jul 13;2021:9953986.

    • Ng HY, Lee WC, Kung CT, Li LC, Lee CT, Fu LM. Recent Advances in Microfluidic Devices for Contamination Detection and Quality Inspection of Milk. Micromachines (Basel). 2021 May 14;12(5):558.

    • Lee WC, Ng HY, Hou CY, Lee CT, Fu LM. Recent advances in lab-on-paper diagnostic devices using blood samples. Lab Chip, 2021,21, 1433-1453.

    • Lee WC, Kuo WH, Moi SH, Chiu B, Chen JB, Yang CH. Associations between Circulating Markers of Cholesterol Homeostasis and Macrovascular Events among Patients Undergoing Hemodialysis. Nutrients. 2021 Mar;13(3):1014.

    • Lee WC, Chen JB, Moi SH, Yang CH. Association of proportion of the HDL-cholesterol subclasses HDL-2b and HDL-3 and macrovascular events among patients undergoing hemodialysis. Sci Rep. 2021 Jan;11(1):1871.

    • Chen JB, Li LC, Lee WC, Moi SH, Yang CH. Effect of clinical factors on trajectory of functional performance in patients undergoing hemodialysis. Ren Fail. 2021 Dec;43(1):90-96.

    • Zhang L, Lee WC, Wu CH, Kuo LC, Yang HT, Moi SH, Yang CH, Chen JB. Importance of non-medical reasons for dropout in patients on peritoneal dialysis. Clin Exp Nephrol. 2020 Nov;24(11):1050-1057.

    • Chen JB, Chang CC, Li LC, Lee WC, Lin CN, Li SC, Moi SH, Yang CH. Mutual Interaction of Clinical Factors and Specific microRNAs to Predict Mild Cognitive Impairment in Patients Receiving Hemodialysis. Cells. 2020 Oct 15;9(10):E2303.

    • Lee WC, Li LC, Ng HY, Lin PT, Chiou TT, Kuo WH, Lee CT. Urinary Exosomal MicroRNA Signatures in Nephrotic, Biopsy-Proven Diabetic Nephropathy. J Clin Med. 2020 Apr 23;9(4):1220.

    • Kao YY, Lee WC, Wang RH, Chen JB. Correlation of sociodemographic profiles with psychological problems among hospitalized patients receiving unplanned hemodialysis. Ren Fail. 2020 Nov;42(1):255-262.

    • Lee WC, Chau YY, Ng HY, Chen CH, Wang PW, Liou CW, Lin TK, Chen JB. Empagliflozin Protects HK-2 Cells from High Glucose-Mediated Injuries via a Mitochondrial Mechanism. Cells. 2019 Sep 14;8(9):1085.

    • Liu HY, Cheng YT, Luo HL, Huang CC, Chen CH, Shen YC, Lee WC*. Modest dose anti-thymocyte globulin administered intraoperatively is safe and effective in kidney transplantations: a retrospective study. PeerJ. 2019 Aug 16;7:e7274.

    • Wang Y, Lee YT, Lee WC, Ng HY, Wu CH, Lee CT. Goal attainment and renal outcomes in patients enrolled in the chronic kidney disease care program in Taiwan: a 3-year observational study. Int J Qual Health Care. 2019 May 1;31(4):252-260. (SCI；IF=2.257；Health Care Sciences & Services

    • Li LC, Yang JL, Lee WC, Chen JB, Lee CT, Wang PW, Vaghese Z, Chen WY. Palmitate aggravates proteinuria-induced cell death and inflammation via CD36-inflammasome axis in the proximal tubular cells of obese mice. Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1720-F1731.

    • Lee WC, Lee YT, Li LC, Ng HY, Kuo WH, Lin PT, Liao YC, Chiou TT, Lee CT. The Number of Comorbidities Predicts Renal Outcomes in Patients with Stage 3?5 Chronic Kidney Disease. J Clin Med. 2018 Nov 28;7(12):493.

    • Wu PJ, Chen JB, Lee WC, Ng HY, Lien SC, Tsai PY, Wu CH, Lee CT, Chiou TT. Oxidative Stress and Nonalcoholic Fatty Liver Disease in Hemodialysis Patients. Biomed Res Int. 2018 Nov 1;2018:3961748.

    • Chang YL, Cheng YT, Chen TC, Chien YS, Lee WC, Shen YC. Nucleic Acid Tests for BK Polyomavirus Is Critical in Renal Transplant Recipients. Transplant Proc. 2018 Oct;50(8):2489-2492.

    • Chen YY, Chuang YC, Chen JB, Lien CY, Lin WC, Lee CC, Hsu SW, Lee WC, Li LC, Huang CW, Chang CC. Significance of the Ventral Striatal-Network in Dialysis Patients: Structural Covariance Analysis and Relationship with Neurobehavioral Outcomes. Neuropsychiatry. 2018;18:1786-1796

    • Leong, FF, Yu CI, Lee YT, Lee WC, Wu CH, Lee CT, Ng HY. Body Composition and Biochemical Factors Associated with Hyponatremia in Elderly Hemodialysis Patients. 臺灣腎臟醫學會雜誌. 2018;32:177-187

    • Chen JB, Lee WC, Cheng BC, Moi SH, Yang CH, Lin YD. Impact of risk factors on functional status in maintenance hemodialysis patients. Eur J Med Res. 2017 Dec 28;22(1):54.

    • Lee CT, Lee YT, Kuo WH, Chiou TT, Li LC, Ng HY, Chou CA, Lee WC. Factors associated with magnesemia in patients with chronic kidney disease. Magnes Res. 2017 May 1;30(2):53-60.

    • Lee WC, Ruan XZ, Chau YY, Chen JB. Chronic Kidney Disease-Mineral and Bone Disorder. Biomed Res Int. 2017;2017:4875042.

    • Lee WC, Chiu CH, Chen JB, Chen CH, Chang HW. Mitochondrial Fission Increases Apoptosis and Decreases Autophagy in Renal Proximal Tubular Epithelial Cells Treated with High Glucose. DNA Cell Biol. 2016 Nov;35(11):657-665.

    • Liu Y, Lee WC, Cheng BC, Li LC, Lee CH, Chang WX, Chen JB. Association between the Achievement of Target Range CKD-MBD Markers and Mortality in Prevalent Hemodialysis Patients in Taiwan by Using the Kidney Disease: Improving Global Outcomes Clinical Guidelines. Biomed Res Int. 2016;2016:1523124.

    • Liu Y, Cheng BC, Lee WC, Li LC, Lee CH, Chang WX, Chen JB. Serum Potassium Profile and Associated Factors in Incident Peritoneal Dialysis Patients. Kidney Blood Press Res. 2016;41(5):545-551.

    • Liou CW, Chuang JH, Chen JB, Tiao MM, Wang PW, Huang ST, Huang TL, Lee WC, Weng SW, Huang PH, Chen SD, Chen RS, Lu CS, Lin TK Mitochondrial DNA variants as genetic risk factors for Parkinson disease. Eur J Neurol. 2016 Aug;23(8):1289-300. doi: 10.1111/ene.13020.

    • Lee WC, Chiu CH, Chen JB, Chen CH, Chang HW. Mitochondrial Fission Increases Apoptosis and Decreases Autophagy in Renal Proximal Tubular Epithelial Cells Treated with High Glucose. DNA Cell Biol. 2016 Jul 15. (SCI)

    • Lee WC, Li LC, Chen JB, Change HW. Indoxyl sulfate-induced oxidative stress, mitochondrial dysfunction and impaired biogenesis are partly protected by vitamin C and N-acetylcysteine. Sci World J 2015:6. (SCI)

    • Chiu TT, Liao SC, Lee WC, Lee PS, Ng HY, Chien YS, Lee CT. Gelsolin and adipokines are associated with protein-energy wasting in hemodialysis patients. Artif Organs. 2015;39:150-5. (SCI)

    • Chen JB, Chuang LY, Lin YD, Liou CW, Lin TK, Lee WC, Cheng BC, Chang HW, Yang CH. Genetic algorithm-generated SNP barcodes of the mitochondrial D-loop for chronic dialysis susceptibility. Mitochondrial DNA 2014; 25: 231-37(SCI)

    • Chen JB, Chuang LY, Lin YD, Liou CW, Lin TK, Lee WC, Cheng BC, ChangHW, Yang CH. Preventive SNP-SNP interactions in the mitochondrial displacement loop (D-loop) from chronic dialysis patients. Mitochondrion 2013;13: 698-704(SCI)

    • Tain YL, Lee WC, Hsu CN, Lee WC, Huang LT, Lee CT, Lin CY, Asymmetric dimethylarginine is associated with developmental programming of adult kidney disease and hypertension in offspring of streptozotocin-treated mothers. PLoS ONE 8(2): e55420, 2013 (SCI)

    • Chen JB, Su YJ, Lee WC, Cheng BC, Kuo CC, Wu CH, Lin E, Wang YC, Chen TC, Liao SC*, Lam KK. Relationship between Kt/V urea-based dialysis adequacy and nutritional status and their effect on the components of the quality of life in incident peritoneal dialysis patients. BMC Nephrology 2012: 14: 13:39. (SCI)

    • Lee CT*, Lee YT, Ng HY, Chiou TT, Cheng CI, Kuo CC, Wu CH, Chi PJ, Lee WC. Lack of modulatory effect of simvastatin on indoxyl sulfate-induced activation of cultured endothelial cells. Life Sci. 2012: 2;90: 47-53. (SCI)

    • Chau YY, Brownstein D, Mjoseng H, Lee WC, Buza-Vidas N, Nerlov C, Jacobsen SE, Perry P, Berry R, Thornburn A, Sexton D, Morton N, Hohenstein P, Freyer E, Samuel K, van't Hof R, Hastie N*. Acute multiple organ failure in adult mice deleted for the developmental regulator Wt1. PLoS Genet. 2011: 7(12):e1002404. (SCI)

    • Wang YC, Lee WC, Liao SC, Lee LC, Su YJ, Lee CT, Chen JB*. Mitochondrial DNA copy number correlates with oxidative stress and predicts mortality in non-diabetic hemodialysis patients. J Nephrol 2011: 24(3):351-8. (SCI)

    • Wang YC, Chuang FR, Lee WC, Chen TC, Ko SF, Wang IK, Lee CH*. Low-Molecular-Weight Heparin successfully used to treat a nephrotic patient complicated by superior mesenteric vein Thrombosis and Portal Vein Thrombosis. Med Princ Pract. 2011;20(2):196-9. (SCI)

    • Lee WC, Hough MT, Liu W, Ekiert R, Lindstrom NO, Hohenstein P, Davies JA*., Dact2 is expressed in the developing ureteric bud/collecting duct system of the kidney and controls morphogenetic behavior of collecting duct cells. Am J Physiol Renal Physiol, 2010: 299(4): p. F740-51. (SCI)